Structural changes in the narcoleptic brain and their possible relevance for clinical severity

Sleep Medicine

Volumn 13, Issue 7, 2012, Pages 775-776

  Dang Vu, Thien Thanh ^a,b  

^a HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

OREXIN;

ANATOMICAL VARIATION; BRAIN CORTEX; BRAIN REGION; BRAIN SIZE; CATAPLEXY; DAYTIME SOMNOLENCE; DIFFUSION TENSOR IMAGING; DISEASE ASSOCIATION; DISEASE SEVERITY; EDITORIAL; FRACTIONAL ANISOTROPY; FUNCTIONAL NEUROIMAGING; HUMAN; HYPOTHALAMUS; NARCOLEPSY; NEUROANATOMY; NEUROPATHOLOGY; PRIORITY JOURNAL;

BRAIN STEM; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; HUMANS; HYPOTHALAMUS; LEUKOENCEPHALOPATHIES; MALE; NARCOLEPSY;

EID: 84863860025     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2012.04.003     Document Type: Editorial

References (20)

1. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000, 27(3):469-474.
2. Buskova J., Vaneckova M., Sonka K., Seidl Z., Nevsimalova S. Reduced hypothalamic gray matter in narcolepsy with cataplexy. Neuro Endocrinol Lett 2006, 27(6):769-772.
3. Draganski B., Geisler P., Hajak G., Schuierer G., Bogdahn U., Winkler J., et al. Hypothalamic gray matter changes in narcoleptic patients. Nat Med 2002, 8(11):1186-1188.
4. Joo E.Y., Tae W.S., Kim S.T., Hong S.B. Gray matter concentration abnormality in brains of narcolepsy patients. Korean J Radiol 2009, 10(6):552-558.
5. Overeem S., Steens S.C., Good C.D., Ferrari M.D., Mignot E., Frackowiak R.S., et al. Voxel-based morphometry in hypocretin-deficient narcolepsy. Sleep 2003, 26(1):44-46.
6. Kaufmann C., Schuld A., Pollmacher T., Auer D.P. Reduced cortical gray matter in narcolepsy: preliminary findings with voxel-based morphometry. Neurology 2002, 58(12):1852-1855.
7. Brenneis C., Brandauer E., Frauscher B., Schocke M., Trieb T., Poewe W., et al. Voxel-based morphometry in narcolepsy. Sleep Med 2005, 30.
8. Scherfler C., Frauscher B., Schocke M., Nocker M., Gschliesser V., Ehrmann L., et al. White and gray matter abnormalities in narcolepsy with cataplexy. Sleep 2012, 35(3):345-351.
9. Dang-Vu T.T., Desseilles M., Schwartz S., Maquet P. Neuroimaging of narcolepsy. CNS Neurol Disord Drug Targets 2009, 8(4):254-263.
10. Menzler K., Belke M., Unger M.M., Ohletz T., Keil B., Heverhagen J., et al. DTI reveals hypothalamic and brainstem white matter lesions in patients with idiopathic narcolepsy. Sleep Med 2012, 13.
11. Baumann C.R., Khatami R., Werth E., Bassetti C.L. Hypocretin (orexin) deficiency predicts severe objective excessive daytime sleepiness in narcolepsy with cataplexy. J Neurol Neurosurg Psychiatry 2006, 77(3):402-404.
12. Kim S.J., Lyoo I.K., Lee Y.S., Lee J.Y., Yoon S.J., Kim J.E., et al. Gray matter deficits in young adults with narcolepsy. Acta Neurol Scand 2009, 119(1):61-67.
13. Brabec J., Rulseh A., Horinek D., Pala A., Guerreiro H., Buskova J., et al. Volume of the amygdala is reduced in patients with narcolepsy - a structural MRI study. Neuro Endocrinol Lett 2011, 32(5):652-656.
14. Joo E.Y., Kim S.H., Kim S.T., Hong S.B. Hippocampal volume and memory in narcoleptics with cataplexy. Sleep medicine. 2012, 13(4):396-401.
15. Joo E.Y., Jeon S., Lee M., Kim S.T., Yoon U., Koo D.L., et al. Analysis of cortical thickness in narcolepsy patients with cataplexy. Sleep 2011, 34(10):1357-1364.
16. Schaer M, Poryazova R, Schwartz S, Bassetti CL, Baumann CR. Cortical morphometry in narcolepsy with cataplexy. J Sleep Res 2012, in press.
17. Ponz A., Khatami R., Poryazova R., Werth E., Boesiger P., Bassetti C.L., et al. Abnormal activity in reward brain circuits in human narcolepsy with cataplexy. Ann Neurol 2010, 67(2):190-200.
18. Frey J.L., Heiserman J.E. Absence of pontine lesions in narcolepsy. Neurology 1997, 48(4):1097-1099.
19. Yeon Joo E., Hong S.B., Tae W.S., Kim J.H., Han S.J., Cho Y.W., et al. Cerebral perfusion abnormality in narcolepsy with cataplexy. Neuroimage 2005, 28(2):410-416.
20. Schwartz S., Ponz A., Poryazova R., Werth E., Boesiger P., Khatami R., et al. Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy. Brain 2008, 131(Pt. 2):514-522.