Retinal vascular changes following intravitreal ranibizumab injections for neovascular AMD over a 1-year period

Eye (Basingstoke)

Volumn 26, Issue 7, 2012, Pages 958-966

  Wickremasinghe, S S ^a   Xie, J ^a   Guymer, R H ^a   Wong, T Y ^a,b   Kawasaki, R ^a   Qureshi, S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

AMD; anti VEGF; retinal vasculature

Indexed keywords

RANIBIZUMAB;

AGED; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EXUDATIVE MACULAR DEGENERATION; FEMALE; FOLLOW UP; HUMAN; MALE; RETINA ARTERY; RETINA BLOOD VESSEL; RETINA MACULA AGE RELATED DEGENERATION; TREATMENT DURATION; VISUAL ACUITY;

EID: 84863860001     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/eye.2012.72     Document Type: Article

References (37)

1. Grunwald JE, Metelitsina TI, Dupont JC, Ying GS, Maguire MG. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci 2005; 46(3): 1033-1038. (Pubitemid 41321042)
2. Grunwald JE, Hariprasad SM, DuPont J, Maguire MG, Fine SL, Brucker AJ et al. Foveolar choroidal blood flow in age-related macular degeneration. Invest Ophthalmol Vis Sci 1998; 39(2): 385-390. (Pubitemid 28093877)
3. Kwak N, Okamoto N, Wood JM, Campochiaro PA. VEGF is major stimulator in model of choroidal neovascularization. Invest Ophthalmol Vis Sci 2000; 41(10): 3158-3164.
4. Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355(14): 1432-1444. (Pubitemid 44511558)
5. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006; 355(14): 1419-1431. (Pubitemid 44511557)
6. Kabbinavar F, Hurwitz HI, Fehrenbacher L, Meropol NJ, Novotny WF, Lieberman G et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LValone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21(1): 60-65.
7. Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008; 358(11): 1129-1136. (Pubitemid 351398487)
8. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR et al. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 2006; 290(2): H560-H576.
9. Choi YI, Lee SH, Ahn BK, Baek SU, Park SJ, Kim YS et al. Intestinal perforation in colorectal cancers treated with bevacizumab (Avastin). Cancer Res Treat 2008; 40(1): 33-35.
10. Papadopoulou DN, Mendrinos E, Mangioris G, Donati G, Pournaras CJ. Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration. Ophthalmology 2009; 116(9): 1755-1761.
11. Mendrinos E, Mangioris G, Papadopoulou D, Donati G, Pournaras C. One year results of the effect of intravitreal ranibizumab on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 2009; e-pub ahead of print 23 September 2009; doi:10.1167/iovs.09-3721.
12. Fontaine O, Olivier S, Descovich D, Cordahi G, Vaucher E, Lesk MR. The effect of intravitreal injection of bevacizumab on retinal circulation in patients with neovascular macular degeneration. Invest Ophthalmol Vis Sci 2011; 52: 7400-7405.
13. Sun C, Wang JJ, Mackey DA, Wong TY. Retinal vascular caliber: systemic, environmental, and genetic associations. Surv Ophthalmol 2009; 54(1): 74-95.
14. Wong TY, Islam FM, Klein R, Klein BE, Cotch MF, Castro C et al. Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci 2006; 47(6): 2341-2350. (Pubitemid 351639814)
15. Nguyen TT, Islam FM, Farouque HM, Klein R, Klein BE, Cotch MF et al. Retinal vascular caliber and brachial flow-mediated dilation: the multi-ethnic study of atherosclerosis. Stroke 2010; 41(7): 1343-1348.
16. Wong TY, Klein R, Islam FM, Cotch MF, Folsom AR, Klein BE et al. Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol 2006; 141(3): 446-455.
17. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs - an extension of the modified Airlie House classification. Ophthalmology 1991; 98(5 Suppl): 786-806.
18. Hubbard LD, Brothers RJ, King WN, Clegg LX, Klein R, Cooper LS et al. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/ sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 1999; 106(12): 2269-2280. (Pubitemid 30191437)
19. Wong TY, Knudtson MD, Klein R, Klein BE, Meuer SM, Hubbard LD. Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology 2004; 111(6): 1183-1190. (Pubitemid 38736998)
20. Knudtson MD, Lee KE, Hubbard LD, Wong TY, Klein R, Klein BE. Revised formulas for summarizing retinal vessel diameters. Curr Eye Res 2003; 27(3): 143-149. (Pubitemid 37159478)
21. Aiello LP, Brucker AJ, Chang S, Cunningham ET Jr, D'Amico DJ, Flynn HW Jr et al. Evolving guidelines for intravitreous injections. Retina 2004; 24(5 Suppl): S3-S19. (Pubitemid 39391785)
22. Holz FG, Amoaku W, Donate J, Guymer RH, Kellner U, Schlingemann RO et al. Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study. Ophthalmology 2011; 118(4): 663-671.
23. Fung AE, Lalwani GA, Rosenfeld PJ, Dubovy SR, Michels S, Feuer WJ et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol 2007; 143(4): 566-583.
24. Leung H, Wang JJ, Rochtchina E, Tan AG, Wong TY, Klein R et al. Relationships between age, blood pressure, and retinal vessel diameters in an older population. Invest Ophthalmol Vis Sci 2003; 44(7): 2900-2904. (Pubitemid 36759750)
25. Noma H, Funatsu H, Sakata K, Harino S, Nagaoka T, Mimura T et al. Macular microcirculation and macular oedema in branch retinal vein occlusion. Br J Ophthalmol 2009; 93(5): 630-633.
26. Horio N, Horiguchi M. Effect of arteriovenous sheathotomy on retinal blood flow and macular edema in patients with branch retinal vein occlusion. Am J Ophthalmol 2005; 139(4): 739-740.
27. Ciulla TA, Harris A, Chung HS, Danis RP, Kagemann L, McNulty L et al. Color Doppler imaging discloses reduced ocular blood flow velocities in nonexudative age-related macular degeneration. Am J Ophthalmol 1999; 128(1): 75-80. (Pubitemid 29315766)
28. Wickremasinghe SS, Michalova K, Gilhotra J, Guymer RH, Harper CA, Wong TY et al. Acute intraocular inflammation after intravitreous injections of bevacizumab for treatment of neovascular age-related macular degeneration. Ophthalmology 2008; 115(11): 1911-1915.
29. Wu L, Martinez-Castellanos MA, Quiroz-Mercado H, Arevalo JF, Berrocal MH, Farah ME et al. Twelve-month safety of intravitreal injections of bevacizumab (avastin): results of the Pan-American Collaborative Retina Study Group (PACORES). Graefes Arch Clin Exp Ophthalmol 2008; 246(1): 81-87. (Pubitemid 350167096)
30. Forooghian F, Cukras C, Meyerle CB, Chew EY, Wong WT. Tachyphylaxis after intravitreal bevacizumab for exudativeage-related macular degeneration. Retina 2009; 29(6):723-731.
31. Couillard C, Ruel G, Archer WR, Pomerleau S, Bergeron J, Couture P et al. Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocrinol Metab 2005; 90(12):6454-6459. (Pubitemid 41759299)
32. Caballero AE. Metabolic and vascular abnormalities in subjects at risk for type 2 diabetes: the early start of a dangerous situation. Arch Med Res 2005; 36(3): 241-249. (Pubitemid 40755137)
33. Klein R, Klein BE, Knudtson MD, Wong TY, Tsai MY. Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study. Arch Ophthalmol 2006; 124(1):87-94. (Pubitemid 43063893)
34. Wieberdink RG, Ikram MK, Koudstaal PJ, Hofman A, Vingerling JR, Breteler MM. Retinal vascular calibers and the risk of intracerebral hemorrhage and cerebral infarction: the Rotterdam Study. Stroke 2010; 41(12): 2757-2761.
35. Gillies MC, Wong TY. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2007; 356(7): 748-749; author reply 49-50.
36. Ueta T, Yanagi Y, Tamaki Y, Yamaguchi T. Cerebrovascular accidents in ranibizumab. Ophthalmology 2009; 116(2): 362.
37. Schmucker C, Ehlken C, Hansen LL, Antes G, Agostini HT, Lelgemann M. Intravitreal bevacizumab (Avastin) vs. ranibizumab (Lucentis) for the treatment of age-related macular degeneration: a systematic review. Curr Opin Ophthalmol 2010; 21(3): 218-226.