Effects of palmitic acid on TNF-α-induced cytotoxicity in SK-Hep-1 cells

Toxicology in Vitro

Volumn 26, Issue 6, 2012, Pages 783-790

  Oh, Jung Min ^a   Choi, Jong Min ^a   Lee, Ji Yoon ^a   Oh, Soo Jin ^b   Kim, Hyoung Chin ^b   Kim, Bong Hee ^a   Ma, Jin Yeul ^c   Kim, Sang Kyum ^a  

^a Chungnam National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

AKT; Apoptosis; Free fatty acid; NASH; PA; TNF

Indexed keywords

GLUTATHIONE; LINOLEIC ACID; MALONALDEHYDE; OLEIC ACID; PALMITIC ACID; PROTEIN KINASE B; STEARIC ACID; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL STRAIN; CELL STRAIN SK HEP 1; CELL SURVIVAL; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; LIPID STORAGE; NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL SURVIVAL; FATTY ACIDS; FATTY LIVER; GLUTATHIONE; HUMANS; MALONDIALDEHYDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863855243     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.05.013     Document Type: Article

References (47)

1. Aggarwal B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 2003, 3:745-756.
2. Araya J., Rodrigo R., Videla L.A., Thielemann L., Orellana M., Pettinelli P., Poniachik J. Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin. Sci. (Lond) 2004, 106:635-643.
3. Bogoyevitch M.A., Ngoei K.R., Zhao T.T., Yeap Y.Y., Ng D.C. C-Jun N-terminal kinase (JNK) signaling: recent advances and challenges. Biochim. Biophys. Acta 2010, 1804:463-475.
4. Cazanave S.C., Mott J.L., Elmi N.A., Bronk S.F., Werneburg N.W., Akazawa Y., Kahraman A., Garrison S.P., Zambetti G.P., Charlton M.R., Gores G.J. JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J. Biol. Chem. 2009, 284:26591-26602.
5. Cohen G.M. Caspases: the executioners of apoptosis. Biochem. J. 1997, 326(Pt 1):1-16.
6. Crespo J., Cayon A., Fernandez-Gil P., Hernandez-Guerra M., Mayorga M., Dominguez-Diez A., Fernandez-Escalante J.C., Pons-Romero F. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 2001, 34:1158-1163.
7. Day C.P., James O.F. Steatohepatitis: a tale of two "hits" ?. Gastroenterology 1998, 114:842-845.
8. Donato M.T., Lahoz A., Jimenez N., Perez G., Serralta A., Mir J., Castell J.V., Gomez-Lechon M.J. Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts. Drug Metab. Dispos. 2006, 34:1556-1562.
9. Duriez P.J., Shah G.M. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem. Cell Biol. 1997, 75:337-349.
10. El-Assaad W., Buteau J., Peyot M.L., Nolan C., Roduit R., Hardy S., Joly E., Dbaibo G., Rosenberg L., Prentki M. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology 2003, 144:4154-4163.
11. Feldstein A.E., Canbay A., Guicciardi M.E., Higuchi H., Bronk S.F., Gores G.J. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J. Hepatol. 2003, 39:978-983.
12. Garcia M.C., Amankwa-Sakyi M., Flynn T.J. Cellular glutathione in fatty liver in vitro models. Toxicol. In Vitro 2011, 25:1501-1506.
13. Gomez-Lechon M.J., Donato M.T., Martinez-Romero A., Jimenez N., Castell J.V., O'Connor J.E. A human hepatocellular in vitro model to investigate steatosis. Chem. Biol. Interact. 2007, 165:106-116.
14. Gremlich S., Nolan C., Roduit R., Burcelin R., Peyot M.L., Delghingaro-Augusto V., Desvergne B., Michalik L., Prentki M., Wahli W. Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation. Endocrinology 2005, 146:375-382.
15. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 1980, 106:207-212.
16. Hatano E., Brenner D.A. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 281:G1357-1368.
17. Hui J.M., Hodge A., Farrell G.C., Kench J.G., Kriketos A., George J. Beyond insulin resistance in NASH: TNF-alpha or adiponectin?. Hepatology 2004, 40:46-54.
18. Kern P.A., Saghizadeh M., Ong J.M., Bosch R.J., Deem R., Simsolo R.B. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 1995, 95:2111-2119.
19. Kim S.K., Woodcroft K.J., Novak R.F. Insulin and glucagon regulation of glutathione S-transferase expression in primary cultured rat hepatocytes. J. Pharmacol. Exp. Ther. 2003, 305:353-361.
20. Kim S.K., Woodcroft K.J., Oh S.J., Abdelmegeed M.A., Novak R.F. Role of mechanical and redox stress in activation of mitogen-activated protein kinases in primary cultured rat hepatocytes. Biochem. Pharmacol. 2005, 70:1785-1795.
21. Larter C.Z., Farrell G.C. Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?. J. Hepatol. 2006, 44:253-261.
22. Larter C.Z., Yeh M.M. Animal models of NASH: getting both pathology and metabolic context right. J. Gastroenterol. Hepatol. 2008, 23:1635-1648.
23. Lichtman S.N., Wang J., Zhang C., Lemasters J.J. Endocytosis and Ca2+ are required for endotoxin-stimulated TNF-alpha release by rat Kupffer cells. Am. J. Physiol. 1996, 271:G920-928.
24. Ludwig J., Viggiano T.R., McGill D.B., Oh B.J. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc. 1980, 55:434-438.
25. Malaguarnera M., Di Rosa M., Nicoletti F., Malaguarnera L. Molecular mechanisms involved in NAFLD progression. J. Mol. Med. (Berl) 2009, 87:679-695.
26. Malinowski J.M., Bolesta S. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin. Ther. 2000, 22:1151-1168. discussion 1149-1150.
27. Mantzaris M.D., Tsianos E.V., Galaris D. Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells. FEBS J. 2011, 278:519-530.
28. Miller T.A., LeBrasseur N.K., Cote G.M., Trucillo M.P., Pimentel D.R., Ido Y., Ruderman N.B., Sawyer D.B. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochem. Biophys. Res. Commun. 2005, 336:309-315.
29. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
30. Nolan C.J., Larter C.Z. Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it?. J. Gastroenterol. Hepatol. 2009, 24:703-706.
31. Pessayre D., Berson A., Fromenty B., Mansouri A. Mitochondria in steatohepatitis. Semin. Liver Dis. 2001, 21:57-69.
32. Prentki M., Madiraju S.R. Glycerolipid metabolism and signaling in health and disease. Endocr. Rev. 2008, 29:647-676.
33. Przybytkowski E., Joly E., Nolan C.J., Hardy S., Francoeur A.M., Langelier Y., Prentki M. Upregulation of cellular triacylglycerol - free fatty acid cycling by oleate is associated with long-term serum-free survival of human breast cancer cells. Biochem. Cell Biol. 2007, 85:301-310.
34. Ratziu V., Giral P., Jacqueminet S., Charlotte F., Hartemann-Heurtier A., Serfaty L., Podevin P., Lacorte J.M., Bernhardt C., Bruckert E., Grimaldi A., Poynard T. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 2008, 135:100-110.
35. Rho M.C., Ah Lee K., Mi Kim S., Sik Lee C., Jeong Jang M., Kook Kim Y., Sun Lee H., Hyun Choi Y., Yong Rhim B., Kim K. Sensitization of vascular smooth muscle cell to TNF-alpha-mediated death in the presence of palmitate. Toxicol. Appl. Pharmacol. 2007, 220:311-319.
36. Ricchi M., Odoardi M.R., Carulli L., Anzivino C., Ballestri S., Pinetti A., Fantoni L.I., Marra F., Bertolotti M., Banni S., Lonardo A., Carulli N., Loria P. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J. Gastroenterol. Hepatol. 2009, 24:830-840.
37. Sanyal A.J., Campbellsargent C., Mirshahi F., Rizzo W.B., Contos M.J., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120:9.
38. Singh R., Wang Y., Schattenberg J.M., Xiang Y., Czaja M.J. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 297:G907-917.
39. Song G., Ouyang G., Bao S. The activation of Akt/PKB signaling pathway and cell survival. J. Cell Mol. Med. 2005, 9:59-71.
40. Srivastava S., Chan C. Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line. Biotechnol. Bioeng. 2008, 99:399-410.
41. Staiger K., Staiger H., Weigert C., Haas C., Haring H.U., Kellerer M. Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation. Diabetes 2006, 55:3121-3126.
42. Sumida Y., Nakashima T., Yoh T., Furutani M., Hirohama A., Kakisaka Y., Nakajima Y., Ishikawa H., Mitsuyoshi H., Okanoue T., Kashima K., Nakamura H., Yodoi J. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J. Hepatol. 2003, 38:32-38.
43. Varfolomeev E.E., Ashkenazi A. Tumor necrosis factor: an apoptosis JuNKie?. Cell 2004, 116:491-497.
44. Videla L.A., Rodrigo R., Orellana M., Fernandez V., Tapia G., Quinones L., Varela N., Contreras J., Lazarte R., Csendes A., Rojas J., Maluenda F., Burdiles P., Diaz J.C., Smok G., Thielemann L., Poniachik J. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin. Sci. (Lond.) 2004, 106:261-268.
45. Volpi N., Tarugi P. Improvement in the high-performance liquid chromatography malondialdehyde level determination in normal human plasma. J. Chromatogr. B Biomed. Sci. Appl. 1998, 713:433-437.
46. Wullaert A., Heyninck K., Beyaert R. Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem. Pharmacol. 2006, 72:1090-1101.
47. Zhang Y., Xu M., Zhang S., Yan L., Yang C., Lu W., Li Y., Cheng H. The role of G protein-coupled receptor 40in lipoapoptosis in mouse beta-cell line NIT-1. J. Mol. Endocrinol. 2007, 38:651-661.