Development of a novel xenotransplantation strategy for treatment of diabetes mellitus in rat hosts and translation to non-human primates

Organogenesis

Volumn 8, Issue 2, 2012, Pages 41-48

  Hammerman, Marc R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Beta cell; Diabetes mellitus; Non human primates; Transplantation; Xenotransplantation

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; INSULIN; PIG INSULIN; PROINSULIN;

DIABETES MELLITUS; EMBRYO DEVELOPMENT; ENTEROENDOCRINE CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE TOLERANCE; GRAFT REJECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOGENICITY; IMMUNOSUPPRESSIVE TREATMENT; IN SITU HYBRIDIZATION; INBRED STRAIN; INSULIN RELEASE; LEWIS RAT; LYMPH NODE; MASS SPECTROMETRY; MESENTERY; MESENTERY LYMPH NODE; NONHUMAN; ORGAN DONOR; PANCREAS ISLET BETA CELL; PANCREAS TRANSPLANTATION; PORCINE EMBRYO; PRIMATE; PRIMORDIUM; REVIEW; RHESUS MONKEY; STREPTOZOCIN DIABETES; TRANSLATIONAL RESEARCH; X CHROMOSOME; XENOTRANSPLANTATION; ZUCKER DIABETIC FATTY RAT;

ANIMALS; BLOOD GLUCOSE; CELL MOVEMENT; DIABETES MELLITUS; EMBRYO, MAMMALIAN; GLUCOSE TOLERANCE TEST; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSION; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPH NODES; MACACA MULATTA; MESENTERY; RATS; RATS, ZUCKER; SWINE; TRANSPLANTATION, HETEROLOGOUS;

MACACA MULATTA; PRIMATES; RATTUS; SUIDAE; SUS;

EID: 84863854688     PISSN: 15476278     EISSN: 15558592     Source Type: Journal    
DOI: 10.4161/org.20930     Document Type: Review

References (23)

1. Hering BJ, Walawalkar N. Pig-to-nonhuman primate islet xenotransplantation. Transpl Immunol 2009; 21:81-6; PMID:19427901; http://dx.doi.org/10.1016/j.trim.2009.05.001.
2. Martin B, Ji S, Maudsley S, Mattson MP. "Control"laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci USA 2010; 107:6127-33; PMID:20194732; http://dx.doi.org/10.1073/pnas.0912955107.
3. Bonow RO, Gheorghiade M. The diabetes epidemic: a national and global crisis. Am J Med 2004; 116:2-10; PMID:15019858; http://dx.doi.org/10.1016/j. amjmed.2003.10.014.
4. Bottino R, Trucco M. Multifaceted therapeutic approaches for a multigenic disease. Diabetes 2005; 54:79-86; PMID:16306345; http://dx.doi.org/10.2337/ diabetes.54.suppl-2.S79.
5. McCullough KP, Keith DS, Meyer KH, Stock PG, Brayman KL, Leichtman AB. Kidney and pancreas transplantation in the United States 1998-2007: access for patients with diabetes and end-stage renal disease. Am J Transplant 2009; 9:894-906; PMID:19341414; http://dx.doi.org/10.1111/j.1600-6143.2009.02566.x.
6. Hammerman MR. Pancreas and kidney transplantation using embryonic donor organs. Organogenesis 2004; 1:3-13; PMID:19521554; http://dx.doi.org/10.4161/ org.1.1.1008.
7. Hammerman MR. Organogenesis of kidney and endocrine pancreas: the window opens. Organogenesis 2007; 3:59-66; PMID:19279701; http://dx.doi.org/10.4161/ org.3.2.5382.
8. Hammerman MR. Organogenetic tolerance. Organogenesis 2010; 6:270-5; PMID:21220963; http://dx.doi.org/10.4161/org.6.4.13283.
9. Rogers SA, Talcott M, Hammerman MR. Transplantation of pig metanephroi. ASAIO J 2003; 49:48-52; PMID:12558307; http://dx.doi.org/10.1097/00002480- 200301000-00008.
10. Rogers SA, Liapis H, Hammerman MR. Normalization of glucose post-transplantation of pig pancreatic anlagen into non-immunosuppressed diabetic rats depends on obtaining anlagen prior to embryonic day 35. Transpl Immunol 2005; 14:67-75; PMID:15935296; http://dx.doi.org/10.1016/j.trim.2005.02. 004.
11. Rogers SA, Chen F, Talcott M, Hammerman MR. Islet cell engraftment and control of diabetes in rats following transplantation of pig pancreatic anlagen. Am J Physiol 2004; 286:502-9.
12. Rogers SA, Hammerman MR. Normalization of glucose post-transplantation into diabetic rats of pig pancreatic primordia preserved in vitro. Organogenesis 2008; 4:48-51; PMID:19279715.
13. Rogers SA, Mohanakumar T, Liapis H, Hammerman MR. Engraftment of cells from porcine islets of Langerhans and normalization of glucose tolerance following transplantation of pig pancreatic primordia in nonimmune-suppressed diabetic rats. Am J Pathol 2010; 177:854-64; PMID:20581052; http://dx.doi.org/ 10.2353/ajpath.2010.091193.
14. Rogers SA, Chen F, Talcott M, Liapis H, Hammerman MR. Glucose tolerance normalization following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic ZDF rats. Transpl Immunol 2006; 16:176-84; PMID:17138051; http://dx.doi.org/10.1016/j.trim.2006.08.007.
15. Rogers SA, Chen F, Talcott MR, Faulkner C, Thomas JM, Thevis M, et al. Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques. Xenotransplantation 2007; 14:591-602; PMID:17991147; http://dx.doi.org/10.1111/j.1399-3089.2007.00429.x.
16. Rogers SA, Tripathi P, Mohanakumar T, Liapis H, Chen F, Talcott MR, et al. Engraftment of cells from porcine islets of Langerhans following transplantation of pig pancreatic primordia in non-immunosuppressed diabetic rhesus macaques. Organogenesis 2011; 7:154-62; PMID:21654197; http://dx.doi.org/10.4161/org.7.3.16522.
17. Hecht G, Eventov-Friedman S, Rosen C, Shezen E, Tchorsh D, Aronovich A, et al. Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model. Proc Natl Acad Sci USA 2009; 106:8659-64; PMID:19433788; http://dx.doi.org/10.1073/pnas.0812253106.
18. Tchorsh-Yutsis D, Hecht G, Aronovich A, Shezen E, Klionsky Y, Rosen C, et al. Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48 and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression. Diabetes 2009; 58:1585-94; PMID:19401429; http://dx.doi.org/10.2337/db09-0112.
19. Hammerman MR. Engraftment of insulin-producing cells from porcine islets in non-immune suppressed rats or non-human primates transplanted previously with embryonic pig pancreas. J Transplantation 2011; 2011:261352.
20. Kin T, Korbutt GS, Rajotte RV. Survival and metabolic function of syngeneic rat islet grafts transplanted in the omental pouch. Am J Transplant 2003; 3:281-5; PMID:12614282; http://dx.doi.org/10.1034/j.1600-6143.2003.00049. x.
21. Kenyon NS, Berman DM, O'Neil JJ, Kenyon M, Vasconcellos AV, Curry W, et al. Survival and function of allogeneic islets implanted in an omental pouch in cynomolgus monkeys (Macaca fascicularis). Xenotransplantation 2007; 14:406.
22. Chaffanjon PC, Kenyon NM, Ricordi C, Kenyon NS. Omental anatomy of non-human primates. Surg Radiol Anat 2005; 27:287-91; PMID:16237487; http://dx.doi.org/10.1007/s00276-005-0329-4.
23. Hoppo T, Komori J, Manohar R, Stolz DB, Lagasse E. Rescue of lethal hepatic failure by hepatized lymph nodes in mice. Gastroenterology 2011; 140:656-66; PMID:21070777; http://dx.doi.org/10.1053/j.gastro.2010.11.006.