Microsatellite instability is uncommon in intestinal mucosa of patients with Crohn's disease

Digestive Diseases and Sciences

Volumn 45, Issue 2, 2000, Pages 378-384

  Noffsinger, Amy ^a,b   Kretschmer, Susan ^a,b   Belli, Jenine ^a,b   Fogt, Franz ^a,b   Fenoglio Preiser, Cecilia ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b PENN PRESBYTERIAN MEDICAL CENTER   (United States)

Author keywords

Colon cancer; Crohn's disease; Inflammatory bowel disease; Replication error phenotype; Ulcerative colitis

Indexed keywords

AMINO ACID SUBSTITUTION; ARTICLE; CANCER RISK; COLON CROHN DISEASE; COLON MUCOSA; DNA REPAIR; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN TISSUE; INTESTINE MUCOSA; MALIGNANT TRANSFORMATION; MICROSATELLITE INSTABILITY; PHENOTYPE; PRIORITY JOURNAL; TISSUE SECTION; ULCERATIVE COLITIS;

ADENOCARCINOMA; ADULT; AGED; COLONIC NEOPLASMS; CROHN DISEASE; FEMALE; HUMANS; INTESTINAL MUCOSA; MALE; MICROSATELLITE REPEATS; MIDDLE AGED;

EID: 0034052881     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005433231058     Document Type: Article

References (47)

1. 1. Hinton JM: Risk of malignant change in ulcerative colitis. Gut 7:427-432, 1966
2. 2. MacDougall IPM: The cancer risk in ulcerative colitis. Lancet 2:655, 1964
3. 3. Sugita A, Sachar DB, Bodian C, Ribiero MB, Aufses AH Jr, Greenstein AJ: Colorectal cancer in ulcerative colitis. Influence of anatomical extent and age at onset on colitis-cancer interval. Gut 32:167-169, 1991
4. 4. Weedon DD, Shorter RG, Ilstrup DM, Huizenga KA, Taylor WF: Crohn's disease and cancer. N Engl J Med 289:1099-1103, 1979
5. 5. Greenstein AJ, Sachar DB, Smith H, Janowitz HD, Aufses AH Jr: Patterns of neoplasia in Crohn's disease and ulcerative colitis. Cancer 46:403-407, 1980
6. 6. Gyde SN, Prior P, Macartney JC, Thompson H, Waterhouse JA, Allan RN: Malignancy in Crohn's disease. Gut 21:1024-1029, 1980
7. 7. Savoca PE, Ballantyne GH, Cahow CE: Gastrointestinal malignancies in Crohn's disease. A 20 year experience. Dis Colon Rectum 33:7-11, 1990
8. 8. Greenstein AJ, Meyers S, Szporn A, Slater G, Janowitz HD, Aufses AH Jr: Colorectal cancer in regional ileitis. Q J Med 62:33-40, 1987
9. 9. Cuvelier C, Bekaert E, De Potter C, Pauwels C, De Vos M, Roels H: Crohn's disease with adenocarcinoma and dysplasia. Macroscopical, histological and immunohistochemical aspects of two cases. Am J Surg Pathol 13:187-196, 1989
10. 10. Greenstein AJ, Sachar DB, Smith H, Janowitz HD, Aufses AH Jr: A comparison of cancer risk in Crohn's disease and ulcerative colitis. Cancer 48:2742-2745, 1981
11. 11. Warren R, Barwick KW: Crohn's colitis with carcinoma and dysplasia. Report of a case and review of 100 small and large bowel resections for Crohn's disease to detect incidence of dysplasia. Am J Surg Pathol 7:151-159, 1983
12. 12. Simpson S, Traube J, Riddell RH: The histologic appearance of dysplasia (precarcinomatous change) in Crohn's disease of the small and large intestine. Gastroenterology 81:492-501, 1981
13. 13. Craft CF, Mendelsohn G, Cooper HS, Yardley JH: Colonic "precancer" in Crohn's disease. Gastroenterology 80:578-584, 1981
14. 14. Burmer GC, Rabinovitch PS, Haggitt RC, Crispin DA, Brentnall TA, Kolli VR, Stevens AC, Rubin CE: Neoplastic progression in ulcerative colitis: Histology, DNA content, and loss of a p53 allele. Gastroenterology 103:1602-1610, 1992
15. 15. Heinen CD, Noffsinger AE, Belli J, Straughen J, Fischer J, Groden J, Fenoglio-Preiser CM: Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation. Genes Chrom Cancer 19:170-175, 1997
16. 16. Noffsinger AE, Miller MA, Cusi MV, Fenoglio-Preiser CM: The pattern of cell proliferation in neoplastic and nonneoplastic lesions in ulcerative colitis. Cancer 78:2307-2312, 1996
17. 17. Burmer GC, Crispin DA, Kolli VR, et al: Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis. Cancer Commun 3:167-172, 1991
18. 18. Burmer GC, Levine DS, Kulander BG, et al: C-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma. Gastroenterology 99:416-420, 1994
19. 19. Yin J, Harpaz N, Tong Y, et al: p53 point mutations in dysplastic and cancerous ulcerative colitis lesions. Gastroenterology 104:1633-1639, 1993
20. 20. Hoque AT, Hahn SA, Schutte M, Kern SE: DPC4 gene mutation in colitis associated neoplasia. Gut 40:120-122, 1997
21. 21. Kern SE, Redston M, Seymour AB, et al: Molecular genetic profiles of colitis-associated neoplasms. Gastroenterology 107:420-428, 1994
22. 22. Chaubert P, Benhattar J, Saraga C, et al: K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. Am J Pathol 144:767-775, 1994
23. 23. Taylor HW, Boyle M, Smith SC, Bustin S, Williams NS: Expression of p53 in colorectal cancer and dysplasia complicating ulcerative colitis. Br J Surg 80:442-444, 1993
24. 24. Suzuki H, Harpaz N, Tarmin L, et al: Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers. Cancer Res 54:4841-4844, 1994
25. 25. Brentnall TA, Crispin DA, Bronner MA, et al: Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 56:1237-1240, 1996
26. 26. Shibata D, Peinado MA, Ionov Y, Malkhosyan S, Perucho M: Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nature Genet 6:273-281, 1994
27. 27. Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, Ahren C, Correa P, Hamilton SR, Morson BC, Sommers SC, Yardley JH: Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications. Hum Pathol 14:931-966, 1983
28. 28. Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260:816-819, 1993
29. 29. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP, Jarvinen H, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle A: Clues to the pathogenesis of familial colorectal cancer. Science 260:816, 1993
30. 30. Ionov YM, Peinado A, Malkhosyan S, Shibata D, Perucho M: Ubiquitous somatic mutation in simple repeated sequences reveals a new mechanism for colonic carcinogenesis. Nature 363:558-561, 1993
31. 31. Lynch HT, Shaw MW, Magnuson CW, Larsen AL, Krush AJ: Hereditary factors in two large midwestern kindreds. Arch Intern Med 117:206-212, 1966
32. 32. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nystrom-Lahti M: Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215-1225, 1993
33. 33. Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nystrom-Lahti M, Pylkkanen L, Heimdal K, Andersen TI, Moller P, Rognum TO, Fossa SD, Haldorsen T, Langmark F, Brogger A, de la Chapelle A, Borresen A-L: Genomic instability in colorectal cancer: Relationship to clinicopathologic variables and family history. Cancer Res 53:5849-5852, 1993
34. 34. Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Vener JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, Peltomaki P, Mecklin JP, de la Chapelle A, Kinzler KW, Vogelstein B: Mutation of a mutL homolog in hereditary colon cancer. Science 263:1625-1628, 1993
35. 35. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kane M, Earabino C, Lipford J, Lindblom A: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368:258-261, 1994
36. 36. Kim H, Jen J, Vogelstein B, Hamilton SR: Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 145:148-156, 1994
37. 37. Liu B, Parsons R, Hamilton SR: hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res 54:4590-4594, 1994
38. 38. Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Dunlop MC, Hamilton SR, Petersen GM, de la Chapelle A, Vogelstein B, Kinzler KW: Mutations in two PMS homologues in hereditary non-polyposis colon cancer. Nature 371:75-80, 1994
39. 39. Bernard-Gallon D, Gosse S, Essioux L, et al: Analyses of linkage to 17q11-q23 in 3 French hereditary non-polyposis colon cancer families. Int J Oncol 6:3, 1995
40. 40. Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S, Willson JK, Kinzler KW: Mutations of GTBP in genetically unstable cells [see comments]. Science 268:1915-1917, 1995
41. 41. Palombo F, Gillinari P, Iaccarino I: GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science 268:1912-1914, 1995
42. 42. Liu B, Parsons R, Papadopoulos N, et al: Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nature Med 2:169-174, 1996
43. 43. Palombo F, Iaccarino I, Nakajima E, et al: hMutS, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Curr Biol 6:1181-1184, 1996
44. 44. Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75:1027-1038, 1993
45. 45. Noffsinger AE, Belli JM, Fogt F, Fischer J, Goldman H, Fenoglio-Preiser CM: A germline hMSH2 alteration is unrelated to colonic microsatellite instability in patients with ulcerative colitis. Hum Pathol 30:8-12, 1999
46. 46. Gillen CD, Walmsley RS, Prior P, Andrews HA, Allan RN: Ulcerative colitis and Crohn's disease: A comparison of the colorectal cancer risk in extensive colitis. Gut 35:1590-1592, 1994
47. 47. Brentnall TA, Rubin CE, Crispin DA, Stevens A, Batchelor RH, Haggitt RC, Bronner MP, Evans JP, McCahill LE, Bilir N, Boland CR, Rabinovitch PS: A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis. Gastroenterology 109:151-155, 1995