Pathologic characteristics of nut midline carcinoma arising in the mediastinum

American Journal of Surgical Pathology

Volumn 36, Issue 8, 2012, Pages 1222-1227

  Evans, Andrew G ^a   French, Christopher A ^a   Cameron, Michael J ^a   Fletcher, Christopher D M ^a   Jackman, David M ^b   Lathan, Christopher S ^b   Sholl, Lynette M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

mediastinum; NUT midline carcinoma; squamous cell carcinoma

Indexed keywords

NUCLEAR PROTEIN; NUT PROTEIN, HUMAN; ONCOPROTEIN;

ADULT; AGED; ARTICLE; CARCINOMA; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; INCIDENCE; MALE; MEDIASTINUM TUMOR; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; CARCINOMA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; INCIDENCE; MALE; MEDIASTINAL NEOPLASMS; MIDDLE AGED; NUCLEAR PROTEINS; ONCOGENE PROTEINS;

EID: 84863814403     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318258f03b     Document Type: Article

References (20)

1. Bellizzi AM, Bruzzi C, French CA, et al. The cytologic features of NUT midline carcinoma. Cancer. 2009;117:508-515.
2. Delmore JE, Issa GC, Lemieux ME, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011;146:904-917.
3. Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-1037. (Pubitemid 32267972)
4. Filippakopoulos P, Qi J, Picaud S, et al. Selective inhibition of BET bromodomains. Nature. 2010;468:1067-1073.
5. French CA. Pathogenesis of NUT midline carcinoma. Annu Rev Pathol. 2012;7:247-265.
6. French CA. Demystified molecular pathology of NUT midline carcinomas. J Clin Pathol. 2010;63:492-496.
7. French CA, Kutok JL, Faquin WC, et al. Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol. 2004;22:4135-4139. (Pubitemid 41185183)
8. French CA, Miyoshi I, Kubonishi I, et al. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003;63:304-307. (Pubitemid 36152484)
9. French CA, Ramirez CL, Kolmakova J, et al. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene. 2008;27:2237-2242. (Pubitemid 351483375)
10. Haack H, Johnson LA, Fry CJ, et al. Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol. 2009;33:984-991.
11. Kees UR, Mulcahy MT, Willoughby ML. Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19). Am J Pediatr Hematol Oncol. 1991;13:459-464.
12. Kubonishi I, Takehara N, Iwata J, et al. Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res. 1991;51:3327-3328.
13. Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363:1693-1703.
14. Lee AC, Kwong YI, Fu KH, et al. Disseminated mediastinal carcinoma with chromosomal translocation (15;19). A distinctive clinicopathologic syndrome. Cancer. 1993;72:2273-2276. (Pubitemid 23280160)
15. Muller S, Filippakopoulos P, Knapp S. Bromodomains as therapeutic targets. Expert Rev Mol Med. 2011;13:e29.
16. Schwartz BE, Hofer MD, Lemieux ME, et al. Differentiation of NUT midline carcinoma by epigenomic reprogramming. Cancer Res. 2011;71:2686-2696.
17. Stelow EB. A review of NUT midline carcinoma. Head Neck Pathol. 2011;5:31-35.
18. Stelow EB, Bellizzi AM, Taneja K, et al. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Am J Surg Pathol. 2008;32:828-834.
19. Stelow EB, French CA. Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). Adv Anat Pathol. 2009;16:92-96.
20. Yan J, Diaz J, Jiao J, et al. Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma. J Biol Chem. 2011;286:27663-27675.