HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics

Kidney International

Volumn 82, Issue 3, 2012, Pages 338-343

  Atta, Mohamed G ^a   Estrella, Michelle M ^a   Kuperman, Michael ^a   Foy, Matthew C ^a   Fine, Derek M ^a   Racusen, Lorraine C ^a   Lucas, Gregory M ^a   Nelson, George W ^b   Warner, Andrew C ^b   Winkler, Cheryl A ^b   Kopp, Jeffrey B ^c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

APOL1; end stage kidney disease; HIV associated nephropathy

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN L1; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; ALLELE; APOL1 GENE; ARTICLE; CLINICAL ASSESSMENT; CLINICAL FEATURE; COHORT ANALYSIS; DISEASE COURSE; ENVIRONMENTAL FACTOR; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HISTOPATHOLOGY; HIV ASSOCIATED NEPHROPATHY; HUMAN; HUMAN TISSUE; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATHOGENESIS; PRIORITY JOURNAL; SURVIVAL TIME; VIRAL PHENOMENA AND FUNCTIONS;

EID: 84863810792     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.111     Document Type: Article

References (20)

1. US Renal Data System (USRDS) 2010 annual data report. National Institutes of Health, National Institute of Diabetes and Digestive Diseases and Kidney Diseases, Bethesda, MD. Available at http://www.usrds.org, accessed July 21, 2011.
2. Kiberd BA, Clase CM. Cumulative risk for developing end-stage renal disease in the US population. J Am Soc Nephrol 2002; 13: 1635-1644. (Pubitemid 34579252)
3. Lucas GM, Lau B, Atta MG et al. Chronic kidney disease incidence, and progression to end-stage renal disease, in HIV-infected individuals: a tale of two races. J Infect Dis 2008; 197: 1548-1557. (Pubitemid 351706485)
4. Freedman BI, Soucie JM, Stone SM et al. Familial clustering of end-stage renal disease in blacks with HIV-associated nephropathy. Am J Kidney Dis 1999; 34: 254-258. (Pubitemid 29362089)
5. Gharavi AG, Ahmad T, Wong RD et al. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci USA 2004; 101: 2488-2493. (Pubitemid 38269338)
6. Papeta N, Chan KT, Prakash S et al. Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression. J Clin Invest 2009; 119: 1178-1188.
7. Akilesh S, Huber TB, Wu H et al. Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci USA 2008; 105: 967-972. (Pubitemid 351282065)
8. Genovese G, Friedman DJ, Ross MD et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 2010; 329: 841-845.
9. Tzur S, Rosset S, Shemer R et al. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. Hum Genet 2010; 128: 345-350.
10. Kopp JB, Nelson GW, Sampath K et al. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 2011; 22: 2129-2137.
11. Freedman BI, Langefeld CD, Lu L et al. Differential effects of MYH9 and APOL1 risk variants on FRMD3 association with diabetic ESRD in African Americans. PLoS Genet 2011; 7: e1002150.
12. D'Agati V, Appel GB. HIV infection and the kidney. J Am Soc Nephrol 1997; 8: 138-152. (Pubitemid 27496526)
13. Atta MG, Gallant JE, Rahman MH et al. Antiretroviral therapy in the treatment of HIV-associated nephropathy. Nephrol Dial Transplant 2006; 21: 2809-2813. (Pubitemid 44542235)
14. Fine DM, Wasser WG, Estrella MM et al. APOL1 risk variants predict histopathology and progression to ESRD in HIV-related kidney disease. J Am Soc Nephrol 2012; 23: 343-350.
15. Fine DM, Garg N, Haas M et al. Cocaine use and hypertensive renal changes in HIV-infected individuals. Clin J Am Soc Nephrol 2007; 2: 1125-1130.
16. Hartleben B, Godel M, Meyer-Schwesinger C et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 2010; 120: 1084-1096.
17. Zhaorigetu S, Wan G, Kaini R et al. ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death. Autophagy 2008; 4: 1079-1082.
18. Wan G, Zhaorigetu S, Liu Z et al. Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. J Biol Chem 2008; 283: 21540-21549.
19. Papeta N, Kiryluk K, Patel A et al. APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. J Am Soc Nephrol 2011; 22: 1991-1996.
20. Shi SR, Datar R, Liu C et al. DNA extraction from archival formalin-fixed, paraffin-embedded tissues: heat-induced retrieval in alkaline solution. Histochem Cell Biol 2004; 122: 211-218. (Pubitemid 39371490)