The association between skin blood flow and edema on epidermal thickness in the diabetic foot

Diabetes Technology and Therapeutics

Volumn 14, Issue 7, 2012, Pages 602-609

  Chao, Clare Y L ^a,b   Zheng, Yong Ping ^a   Cheing, Gladys L Y ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b QUEEN ELIZABETH HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C;

ADULT; AGED; ANKLE BRACHIAL INDEX; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL DIAMETER; CAPILLAROSCOPY; CAPILLARY DIAMETER; CONTROLLED STUDY; CORRELATION ANALYSIS; CUTANEOUS PARAMETERS; DIABETIC FOOT; DIABETIC NEUROPATHY; DISEASE ASSOCIATION; DISEASE DURATION; ECHOGRAPHY; EPIDERMAL THICKNESS; FEMALE; FOOT ULCER; HALLUX; HUMAN; LASER DOPPLER FLOWMETRY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN CAPILLARY; SKIN EDEMA;

AGED; BLOOD FLOW VELOCITY; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 1; DIABETIC FOOT; EDEMA; FEMALE; HALLUX; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; SKIN;

EID: 84863805773     PISSN: 15209156     EISSN: 15578593     Source Type: Journal    
DOI: 10.1089/dia.2011.0301     Document Type: Article

References (34)

1. Mueller MJ, Zou D, Lott DJ: "Pressure gradient" as an indicator of plantar skin injury. Diabetes Care 2005;28:2908-2912.
2. Bennett PJ, Stocks AE, Whittam DJ: Analysis of risk factors for neuropathic foot ulceration in diabetes mellitus. J Am Podiatr Med Assoc 1996;86:112-116
3. Fernando DJ, Masson EA, Veves A, Boulton AJ: Relationship of limited joint mobility to abnormal foot pressures and diabetic foot ulceration. Diabetes Care 1991;14:8-11
4. Zimny S, Dessel F, Ehren M, Pfohl M, Schatz H: Early detection of microcirculatory impairment in diabetic patients with foot at risk. Diabetes Care 2001;24:1810-1814
5. Urbancic-Rovan V, Stefanovska A, Bernjak A, Azman-Juvan K, Kocijancic A: Skin blood flow in the upper and lower extremities of diabetic patients with and without autonomic neuropathy. J Vasc Res 2004;41:535-545
6. Flynn MD, Tooke JE: Diabetic neuropathy and the microcirculation. Diabet Med 1995;12:298-301
7. Belcaro G, Nicolaides AN: The venoarteriolar response in diabetics. Angiology 1991;42:827-835
8. Belcaro G, Nicolaides AN, Volteas N, Leon M: Skin flow thevenoarteriolar response and capillary filtration in diabetics. A 3-year follow-up. Angiology 1992;43:490-495
9. Iwase M, Imoto H, Murata A, Nakamura U, Nohara S, Uchizono Y, Iino K, IidaM: Altered postural regulation of foot skin oxygenation and blood flow in patients with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 2007;115:444-447
10. Silver IA: Local factors in tissue oxygenation. J Clin Pathol Suppl (R Coll Pathol) 1977;11:7-13
11. Duffin AC, Lam A, Kidd R, Chan AK, Donaghue KC: Ultrasonography of plantar soft tissues thickness in young people with diabetes. Diabet Med 2002;19:1009-1013
12. Hashmi F, Malone-Lee J, Hounsell E: Plantar skin in type II diabetes: an investigation of protein glycation and biomechanical properties of plantar epidermis. Eur J Dermatol 2006;16:23-32
13. Huntley AC, Walter RM Jr: Quantitative determination of skin thickness in diabetes mellitus: relationship to disease parameters. J Med 1990;21:257-264
14. Seirafi H, Farsinejad K, Firooz A, Davoudi SM, Robati RM, Hoseini MS, Ehsani AH, Sadr B: Biophysical characteristics of skin in diabetes: a controlled study. J Eur Acad Dermatol Venereol 2009;23:146-149
15. Vogt M, Ermert H: Development and evaluation of a highfrequency ultrasound-based system for in vivo strain imaging of the skin. IEEE Trans Ultrason Ferroelectr Freq Control 2005;52:375-385
16. Mofid Y, Ossant F, Imberdis C, Josse G, Patat F: In-vivo imaging of skin under stress: potential of high-frequency (20 Mhz) static 2-D elastography. IEEE Trans Ultrason Ferroelectr Freq Control 2006;53:925-935
17. El-Zawahry MB, Abdel El-Hameed El-Cheweikh HM, Abd-El-Rahman Ramadan S, Ahmed Bassiouny D, Mohamed Fawzy M: Ultrasound biomicroscopy in the diagnosis of skin diseases. Eur J Dermatol 2007;17:469-475
18. Gniadecka M: Non-invasive methods for determination of oedema and water behavior in the skin. Skin Res Technol 1995;1:55-60
19. Gniadecka M: Localization of dermal edema in lipodermatosclerosis, lymphedema, and cardiac insufficiency. Highfrequency ultrasound examination of intradermal echogenicity. J Am Acad Dermatol 1996;35:37-41.
20. Chao CY, Cheing GL: Microvascular dysfunction in diabetic foot disease and ulceration. Diabetes Metab Res Rev 2009; 25:604-614
21. Chen X, Lin W, Lu S, Shi Y, Zou J, Liu Z, Liao W: Insulin prevents latent skin lesions by inhibiting the generation of advanced glycation end products in streptozotocin-induced diabetic rats. Endocr Pathol 2009;20:163-169
22. Kennedy L, Baynes JW: Non-enzymatic glycosylation and the chronic complications of diabetes: an overview. Diabetologia 1984;26:93-98
23. Sternberg M, Cohen-Forterre L, Peyroux J: Connective tissue in diabetes mellitus: biochemical alterations of the intercellular matrix with special reference to proteoglycans, collagens and basement membrane. Diabete Metab 1985;11:27-50
24. Nikkels-Tassoudji N, Henry F, Letawe C, Pierard- Franchimont C, Lefebvre P, Pierard GE: Mechanical properties of the diabetic waxy skin. Dermatology 1996;192:19-22.
25. Kennedy WR, Wendelschafer-Crabb G, Johnson T: Quantitation of epidermal nerves in diabetic neuropathy. Neurology 1996;47:1042-1048
26. Umapathi T, Tan WL, Loke SC, Soon PC, Tavintharan S, Chan YH: Intraepidermal nerve fiber density as a marker of early diabetic neuropathy. Muscle Nerve 2007;35:591-598
27. Hsieh ST, Lin WM, Chiang HY, Huang IT, Ko MH, Chang YC, Chen WP: Skin innervation and its effects on the epidermis. J Biomed Sci 1997;4:264-268
28. Hsieh ST, Chiang HY, Lin WM: Pathology of nerve terminal degeneration in the skin. J Neuropathol Exp Neurol 2000; 59:297-307
29. Chiang HY, Huang IT, Chen WP, Chien HF, Shun CT, Chang YC, Hsieh ST: Regional difference in epidermal thinning after skin denervation. Exp Neurol 1998;154:137-145
30. Hsieh ST, Choi S, Lin WM, Chang YC, Mcarthur JC, Griffin JW: Epidermal denervation and its effects on keratinocytes and Langerhans cells. J Neurocytol 1996;25:513-524
31. Hsieh ST, Lin WM: Modulation of keratinocyte proliferation by skin innervation. J Invest Dermatol 1999;113:579-586
32. Hagisawa S, Shimada T: Skin morphology and its mechanical properties associated with loading. In: Bader D, Bouten C, Colin D, Oomens C, eds. Pressure Ulcer Research: Current and Future Perspectives. Berlin: Springer-Verlag, 2005: 161-185
33. Houben AJ, Nieuwenhuijzen Kruseman AC, Bouhouch E, Slaaf DW, Schaper NC: Peripheral macro- and microcirculation in short-term insulin-dependent diabetes mellitus: the role of prostaglandins in early haemodynamic changes. Eur J Clin Invest 1993;23:662-667
34. Young MJ, Boulton AJ, MacLeod AF, Williams DR, Sonksen PH: A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993;36:150-154