메뉴 건너뛰기




Volumn 11, Issue 13, 2012, Pages 2518-2525

Combination of gastrin-releasing peptide antagonist with cytotoxic agents produces synergistic inhibition of growth of human experimental colon cancers

Author keywords

5 FU; BN GRP antagonist; Colon cancer; Cytotoxic agents; Irinotecan; RC 3940 II; Targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; GASTRIN RELEASING PEPTIDE RECEPTOR; IRINOTECAN; RC 3940; UNCLASSIFIED DRUG;

EID: 84863800757     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.20900     Document Type: Article
Times cited : (23)

References (44)
  • 2
    • 36048960109 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
    • PMID:17947725
    • Fuchs CS, Marshall J, Mitchell E, Wierzbicki R, Ganju V, Jeffery M, et al. Randomized, controlled trial of irinotecan plus infusional, bolus or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol 2007; 25:4779-86; PMID:17947725; http://dx.doi.org/10.1200/JCO.2007.11.3357.
    • (2007) J Clin Oncol , vol.25 , pp. 4779-4786
    • Fuchs, C.S.1    Marshall, J.2    Mitchell, E.3    Wierzbicki, R.4    Ganju, V.5    Jeffery, M.6
  • 3
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • PMID:14657227
    • Tournigand C, André T, Achille E, Lledo G, Flesh M, Mery-Mignard D, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004; 22:229-37; PMID:14657227; http://dx.doi.org/10.1200/JCO.2004.05.113.
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    André, T.2    Achille, E.3    Lledo, G.4    Flesh, M.5    Mery-Mignard, D.6
  • 4
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer
    • PMID:15175435
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-42; PMID:15175435; http://dx.doi.org/10.1056/NEJMoa032691.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 5
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • PMID:19339720
    • Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360:1408-17; PMID:19339720; http://dx.doi.org/10.1056/NEJMoa0805019.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Köhne, C.H.2    Hitre, E.3    Zaluski, J.4    Chang Chien, C.R.5    Makhson, A.6
  • 6
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • PMID:20921465
    • Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 2010; 28:4697-705; PMID:20921465; http://dx.doi.org/10.1200/JCO.2009.27.4860.
    • (2010) J Clin Oncol , vol.28 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3    Tabernero, J.4    Burkes, R.5    Barugel, M.6
  • 8
    • 33746840154 scopus 로고    scopus 로고
    • Gastrin-releasing peptide and cancer
    • PMID:16490321.
    • Patel O, Shulkes A, Baldwin GS. Gastrin-releasing peptide and cancer. Biochim Biophys Acta 2006; 1766:23-41; PMID:16490321.
    • (2006) Biochim Biophys Acta , vol.1766 , pp. 23-41
    • Patel, O.1    Shulkes, A.2    Baldwin, G.S.3
  • 9
    • 33847039876 scopus 로고    scopus 로고
    • Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells
    • PMID:16909108
    • Corral RS, Iñiguez MA, Duque J, López-Pérez R, Fresno M. Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. Oncogene 2007; 26:958-69; PMID:16909108; http://dx.doi.org/10. 1038/sj.onc.1209856.
    • (2007) Oncogene , vol.26 , pp. 958-969
    • Corral, R.S.1    Iñiguez, M.A.2    Duque, J.3    López-Pérez, R.4    Fresno, M.5
  • 10
    • 0142248170 scopus 로고    scopus 로고
    • Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues
    • PMID:14570743
    • Thomas RP, Hellmich MR, Townsend CM Jr, Evers BM. Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues. Endocr Rev 2003; 24:571-99; PMID:14570743; http://dx.doi.org/10.1210/er.2002- 0028.
    • (2003) Endocr Rev , vol.24 , pp. 571-599
    • Thomas, R.P.1    Hellmich, M.R.2    Townsend Jr., C.M.3    Evers, B.M.4
  • 12
    • 0026347281 scopus 로고
    • Inhibition of growth of HT-29 human colon cancer xenografts in nude mice by treatment with bombesin/gastrin-releasing peptide antagonist (RC-3095)
    • PMID:1682040.
    • Radulovic S, Miller G, Schally AV. Inhibition of growth of HT-29 human colon cancer xenografts in nude mice by treatment with bombesin/gastrin- releasing peptide antagonist (RC-3095). Cancer Res 1991; 51:6006-9; PMID:1682040.
    • (1991) Cancer Res , vol.51 , pp. 6006-6009
    • Radulovic, S.1    Miller, G.2    Schally, A.V.3
  • 13
    • 0028028369 scopus 로고
    • Inhibitory effects of antagonists of bombesin/gastrin-releasing peptide (GRP) and somatostatin analog (RC-160) on growth of HT-29 human colon cancers in nude mice
    • PMID:7946450
    • Radulovic S, Schally AV, Reile H, Halmos G, Szepeshazi K, Groot K, et al. Inhibitory effects of antagonists of bombesin/gastrin-releasing peptide (GRP) and somatostatin analog (RC-160) on growth of HT-29 human colon cancers in nude mice. Acta Oncol 1994; 33:693-701; PMID:7946450; http://dx.doi.org/10.3109/ 02841869409121784.
    • (1994) Acta Oncol , vol.33 , pp. 693-701
    • Radulovic, S.1    Schally, A.V.2    Reile, H.3    Halmos, G.4    Szepeshazi, K.5    Groot, K.6
  • 15
    • 0029025541 scopus 로고
    • 2 show high binding-affinity to bombesin/grp receptors on cfpac-1 human pancreatic-cancer cells
    • PMID:21556653.
    • 2 show high binding-affinity to bombesin/grp receptors on cfpac-1 human pancreatic-cancer cells. Int J Oncol 1995; 6:1165-72; PMID:21556653.
    • (1995) Int J Oncol , vol.6 , pp. 1165-1172
    • Cai, R.1    Qin, Y.2    Ertl, T.3    Schally, A.4
  • 16
    • 13844276723 scopus 로고    scopus 로고
    • Antagonists of bombesin/gastrin-releasing peptide decrease the expression of angiogenic and anti-apoptotic factors in human glioblastoma
    • PMID:15655413
    • Kanashiro CA, Schally AV, Cai RZ, Halmos G. Antagonists of bombesin/gastrin-releasing peptide decrease the expression of angiogenic and anti-apoptotic factors in human glioblastoma. Anticancer Drugs 2005; 16:159-65; PMID:15655413; http://dx.doi.org/10.1097/00001813-200502000-00007.
    • (2005) Anticancer Drugs , vol.16 , pp. 159-165
    • Kanashiro, C.A.1    Schally, A.V.2    Cai, R.Z.3    Halmos, G.4
  • 17
    • 0842286816 scopus 로고    scopus 로고
    • Bombesin antagonists inhibit proangiogenic factors in human experimental breast cancers
    • PMID:14710236
    • Bajo AM, Schally AV, Groot K, Szepeshazi K. Bombesin antagonists inhibit proangiogenic factors in human experimental breast cancers. Br J Cancer 2004; 90:245-52; PMID:14710236; http://dx.doi.org/10.1038/sj.bjc.6601404.
    • (2004) Br J Cancer , vol.90 , pp. 245-252
    • Bajo, A.M.1    Schally, A.V.2    Groot, K.3    Szepeshazi, K.4
  • 18
    • 36749087641 scopus 로고    scopus 로고
    • Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2 and pAkt
    • PMID:18003891
    • Hohla F, Schally AV, Kanashiro CA, Buchholz S, Baker B, Kannadka C, et al. Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2 and pAkt. Proc Natl Acad Sci USA 2007; 104:18671-6; PMID:18003891; http://dx.doi.org/10.1073/pnas.0709455104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 18671-18676
    • Hohla, F.1    Schally, A.V.2    Kanashiro, C.A.3    Buchholz, S.4    Baker, B.5    Kannadka, C.6
  • 19
    • 0032032276 scopus 로고    scopus 로고
    • Inhibition of the growth of Caki-I human renal adenocarcinoma in vivo by luteinizing hormone-releasing hormone antagonist Cetrorelix, somatostatin analog RC-160 and bombesin antagonist RC-3940-II
    • PMID:9486581
    • Jungwirth A, Schally AV, Halmos G, Groot K, Szepeshazi K, Pinski J, et al. Inhibition of the growth of Caki-I human renal adenocarcinoma in vivo by luteinizing hormone-releasing hormone antagonist Cetrorelix, somatostatin analog RC-160 and bombesin antagonist RC-3940-II. Cancer 1998; 82:909-17; PMID:9486581; http://dx.doi.org/10.1002/(SICI)1097-0142(19980301)82:5〈909:: AIDCNCR16〉3.0.CO;2-4.
    • (1998) Cancer , vol.82 , pp. 909-917
    • Jungwirth, A.1    Schally, A.V.2    Halmos, G.3    Groot, K.4    Szepeshazi, K.5    Pinski, J.6
  • 20
    • 22144454137 scopus 로고    scopus 로고
    • Antagonists of growth hormone releasing hormone and bombesin inhibit the expression of EGF/HER receptor family in H-69 small cell lung carcinoma
    • PMID:16039952
    • Kanashiro CA, Schally AV, Varga JL, Hammann B, Halmos G, Zarandi M. Antagonists of growth hormone releasing hormone and bombesin inhibit the expression of EGF/HER receptor family in H-69 small cell lung carcinoma. Cancer Lett 2005; 226:123-31; PMID:16039952; http://dx.doi.org/10.1016/j.canlet.2005. 01.008.
    • (2005) Cancer Lett , vol.226 , pp. 123-131
    • Kanashiro, C.A.1    Schally, A.V.2    Varga, J.L.3    Hammann, B.4    Halmos, G.5    Zarandi, M.6
  • 21
    • 27744575622 scopus 로고    scopus 로고
    • Inhibition of human androgenin-dependent PC-3 and DU-145 prostate cancers by antagonists of bombesin and growth hormone releasing hormone is linked to PKC, MAPK and c-jun intracellular signalling
    • PMID:16291086
    • Stangelberger A, Schally AV, Varga JL, Zarandi M, Cai RZ, Baker B, et al. Inhibition of human androgenin-dependent PC-3 and DU-145 prostate cancers by antagonists of bombesin and growth hormone releasing hormone is linked to PKC, MAPK and c-jun intracellular signalling. Eur J Cancer 2005; 41:2735-44; PMID:16291086; http://dx.doi.org/10.1016/j.ejca.2005.08.022.
    • (2005) Eur J Cancer , vol.41 , pp. 2735-2744
    • Stangelberger, A.1    Schally, A.V.2    Varga, J.L.3    Zarandi, M.4    Cai, R.Z.5    Baker, B.6
  • 22
    • 2442604328 scopus 로고    scopus 로고
    • New approaches to therapy of cancers of the stomach, colon and pancreas based on peptide analogs
    • PMID:15112052
    • Schally AV, Szepeshazi K, Nagy A, Comaru-Schally AM, Halmos G. New approaches to therapy of cancers of the stomach, colon and pancreas based on peptide analogs. Cell Mol Life Sci 2004; 61:1042-68; PMID:15112052; http://dx.doi.org/10.1007/s00018-004-3434-3.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 1042-1068
    • Schally, A.V.1    Szepeshazi, K.2    Nagy, A.3    Comaru-Schally, A.M.4    Halmos, G.5
  • 23
    • 41149176081 scopus 로고    scopus 로고
    • LXVIII. Mammalian bombesin receptors: Nomenclature, distribution, pharmacology, signaling and functions in normal and disease states
    • International Union of Pharmacology. PMID:18055507
    • Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling and functions in normal and disease states. Pharmacol Rev 2008; 60:1-42; PMID:18055507; http://dx.doi.org/10.1124/pr.107.07108.
    • (2008) Pharmacol Rev , vol.60 , pp. 1-42
    • Jensen, R.T.1    Battey, J.F.2    Spindel, E.R.3    Benya, R.V.4
  • 24
    • 0026701923 scopus 로고
    • Molecular cloning of a new bombesin receptor subtype expressed in uterus during pregnancy
    • PMID:1325907
    • Gorbulev V, Akhundova A, Büchner H, Fahrenholz F. Molecular cloning of a new bombesin receptor subtype expressed in uterus during pregnancy. Eur J Biochem 1992; 208:405-10; PMID:1325907; http://dx.doi.org/10.1111/j.1432-033. 1992.tb17201.x.
    • (1992) Eur J Biochem , vol.208 , pp. 405-410
    • Gorbulev, V.1    Akhundova, A.2    Büchner, H.3    Fahrenholz, F.4
  • 25
    • 0030758098 scopus 로고    scopus 로고
    • Location and characterization of the human GRP receptor expressed by gastrointestinal epithelial cells
    • PMID:9213359
    • Ferris HA, Carroll RE, Lorimer DL, Benya RV. Location and characterization of the human GRP receptor expressed by gastrointestinal epithelial cells. Peptides 1997; 18:663-72; PMID:9213359; http://dx.doi.org/10. 1016/S0196-9781(97)00127-7.
    • (1997) Peptides , vol.18 , pp. 663-672
    • Ferris, H.A.1    Carroll, R.E.2    Lorimer, D.L.3    Benya, R.V.4
  • 26
    • 0032895181 scopus 로고    scopus 로고
    • Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans
    • PMID:10070042.
    • Carroll RE, Matkowskyj KA, Chakrabarti S, McDonald TJ, Benya RV. Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans. Am J Physiol 1999; 276:655-65; PMID:10070042.
    • (1999) Am J Physiol , vol.276 , pp. 655-665
    • Carroll, R.E.1    Matkowskyj, K.A.2    Chakrabarti, S.3    McDonald, T.J.4    Benya, R.V.5
  • 27
    • 0033986991 scopus 로고    scopus 로고
    • Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa
    • PMID:10638978.
    • Chave HS, Gough AC, Palmer K, Preston SR, Primrose JN. Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa. Br J Cancer 2000; 82:124-30; PMID:10638978.
    • (2000) Br J Cancer , vol.82 , pp. 124-130
    • Chave, H.S.1    Gough, A.C.2    Palmer, K.3    Preston, S.R.4    Primrose, J.N.5
  • 28
    • 7444266737 scopus 로고    scopus 로고
    • Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor
    • PMID:15498503
    • Patel O, Dumesny C, Giraud AS, Baldwin GS, Shulkes A. Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor. Biochem Pharmacol 2004; 68:2129-42; PMID:15498503; http://dx.doi.org/10.1016/j.bcp.2004. 08.009.
    • (2004) Biochem Pharmacol , vol.68 , pp. 2129-2142
    • Patel, O.1    Dumesny, C.2    Giraud, A.S.3    Baldwin, G.S.4    Shulkes, A.5
  • 29
    • 0026680851 scopus 로고
    • The binding of bombesin and somatostatin and their analogs to human colon cancers
    • PMID:1352046.
    • Radulovic SS, Milovanovic SR, Cai RZ, Schally AV. The binding of bombesin and somatostatin and their analogs to human colon cancers. Proc Soc Exp Biol Med 1992; 200:394-401; PMID:1352046.
    • (1992) Proc Soc Exp Biol Med , vol.200 , pp. 394-401
    • Radulovic, S.S.1    Milovanovic, S.R.2    Cai, R.Z.3    Schally, A.V.4
  • 30
    • 0029034647 scopus 로고
    • High-affinity binding sites for gastrin-releasing peptide on human colorectal cancer tissue but not uninvolved mucosa
    • PMID:7734305
    • Preston SR, Woodhouse LF, Jones-Blackett S, Miller GV, Primrose JN. High-affinity binding sites for gastrin-releasing peptide on human colorectal cancer tissue but not uninvolved mucosa. Br J Cancer 1995; 71:1087-9; PMID:7734305; http://dx.doi.org/10.1038/bjc.1995.210.
    • (1995) Br J Cancer , vol.71 , pp. 1087-1089
    • Preston, S.R.1    Woodhouse, L.F.2    Jones-Blackett, S.3    Miller, G.V.4    Primrose, J.N.5
  • 31
    • 0032991986 scopus 로고    scopus 로고
    • High gastrin-releasing peptide receptor mRNA level is related to tumour dedifferentiation and lymphatic vessel invasion in human colon cancer
    • PMID:10211100
    • Saurin JC, Rouault JP, Abello J, Berger F, Remy L, Chayvialle JA. High gastrin-releasing peptide receptor mRNA level is related to tumour dedifferentiation and lymphatic vessel invasion in human colon cancer. Eur J Cancer 1999; 35:125-32; PMID:10211100; http://dx.doi.org/10.1016/S0959-8049(98) 00276-7.
    • (1999) Eur J Cancer , vol.35 , pp. 125-132
    • Saurin, J.C.1    Rouault, J.P.2    Abello, J.3    Berger, F.4    Remy, L.5    Chayvialle, J.A.6
  • 32
    • 0031817358 scopus 로고    scopus 로고
    • Gastrointestinal peptide signaling through tyrosine phosphorylation of focal adhesion proteins
    • PMID:9688642.
    • Rozengurt EV. Gastrointestinal peptide signaling through tyrosine phosphorylation of focal adhesion proteins. Am J Physiol 1998; 275:177-82; PMID:9688642.
    • (1998) Am J Physiol , vol.275 , pp. 177-182
    • Rozengurt, E.V.1
  • 33
    • 0023190226 scopus 로고
    • Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: Inhibition by pertussis toxin
    • PMID:3031676
    • Rozengurt E, Murray M, Zachary I, Collins M. Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin. Proc Natl Acad Sci USA 1987; 84:2282-6; PMID:3031676; http://dx.doi.org/10.1073/ pnas.84.8.2282.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2282-2286
    • Rozengurt, E.1    Murray, M.2    Zachary, I.3    Collins, M.4
  • 34
    • 33947727520 scopus 로고    scopus 로고
    • Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib
    • PMID:17349623
    • Liu X, Carlisle DL, Swick MC, Gaither-Davis A, Grandis JR, Siegfried JM. Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib. Exp Cell Res 2007; 313:1361-72; PMID:17349623; http://dx.doi.org/10.1016/j.yexcr.2007.01.016.
    • (2007) Exp Cell Res , vol.313 , pp. 1361-1372
    • Liu, X.1    Carlisle, D.L.2    Swick, M.C.3    Gaither-Davis, A.4    Grandis, J.R.5    Siegfried, J.M.6
  • 35
    • 0031741856 scopus 로고    scopus 로고
    • Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists
    • PMID:10092204
    • Rozengurt E. Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists. J Cell Physiol 1998; 177:507-17; PMID:10092204; http://dx.doi.org/10.1002/(SICI)1097-4652(199812)177:4〈507: :AIDJCP2〉3.0.CO;2-K.
    • (1998) J Cell Physiol , vol.177 , pp. 507-517
    • Rozengurt, E.1
  • 36
    • 0142025133 scopus 로고    scopus 로고
    • Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor
    • PMID:13679857
    • Lui VW, Thomas SM, Zhang Q, Wentzel AL, Siegfried JM, Li JY, et al. Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor. Oncogene 2003; 22:6183-93; PMID:13679857; http://dx.doi.org/10.1038/sj.onc. 1206720.
    • (2003) Oncogene , vol.22 , pp. 6183-6193
    • Lui, V.W.1    Thomas, S.M.2    Zhang, Q.3    Wentzel, A.L.4    Siegfried, J.M.5    Li, J.Y.6
  • 37
    • 18644367044 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells
    • PMID:15967120
    • Thomas SM, Grandis JR, Wentzel AL, Gooding WE, Lui VW, Siegfried JM. Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells. Neoplasia 2005; 7:426-31; PMID:15967120; http://dx.doi.org/10.1593/neo.04454.
    • (2005) Neoplasia , vol.7 , pp. 426-431
    • Thomas, S.M.1    Grandis, J.R.2    Wentzel, A.L.3    Gooding, W.E.4    Lui, V.W.5    Siegfried, J.M.6
  • 38
    • 0029965317 scopus 로고    scopus 로고
    • Correlation between the effects of bombesin antagonists on cell proliferation and intracellular calcium concentration in Swiss 3T3 and HT-29 cell lines
    • PMID:8643644
    • Casanueva FF, Perez FR, Casabiell X, Camiña JP, Cai RZ, Schally AV. Correlation between the effects of bombesin antagonists on cell proliferation and intracellular calcium concentration in Swiss 3T3 and HT-29 cell lines. Proc Natl Acad Sci USA 1996; 93:1406-11; PMID:8643644; http://dx.doi.org/10.1073/ pnas.93.4.1406.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1406-1411
    • Casanueva, F.F.1    Perez, F.R.2    Casabiell, X.3    Camiña, J.P.4    Cai, R.Z.5    Schally, A.V.6
  • 39
    • 0035655439 scopus 로고    scopus 로고
    • Comparative study of serotonin and bombesin in adenocarcinomas and neuroendocrine tumors of the colon
    • PMID:11783909
    • Seretis E, Gavrill A, Agnantis N, Golematis V, Voloudakis-Baltatzis IE. Comparative study of serotonin and bombesin in adenocarcinomas and neuroendocrine tumors of the colon. Ultrastruct Pathol 2001; 25:445-54; PMID:11783909; http://dx.doi.org/10.1080/019131201753343485.
    • (2001) Ultrastruct Pathol , vol.25 , pp. 445-454
    • Seretis, E.1    Gavrill, A.2    Agnantis, N.3    Golematis, V.4    Voloudakis-Baltatzis, I.E.5
  • 40
    • 0027210739 scopus 로고
    • Effect of bombesin, gastrin-releasing peptide (GRP) (14-27) and bombesin/GRP receptor antagonist RC-3095 on growth of nitrosamine-induced pancreatic cancers in hamsters
    • PMID:8387464
    • Szepeshazi K, Schally AV, Groot K, Halmos G. Effect of bombesin, gastrin-releasing peptide (GRP) (14-27) and bombesin/GRP receptor antagonist RC-3095 on growth of nitrosamine-induced pancreatic cancers in hamsters. Int J Cancer 1993; 54:282-9; PMID:8387464; http://dx.doi.org/10.1002/ijc.2910540220.
    • (1993) Int J Cancer , vol.54 , pp. 282-289
    • Szepeshazi, K.1    Schally, A.V.2    Groot, K.3    Halmos, G.4
  • 41
    • 70349916272 scopus 로고    scopus 로고
    • GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells
    • PMID:19755849
    • Hohla F, Buchholz S, Schally AV, Seitz S, Rick FG, Szalontay L, et al. GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells. Cell Cycle 2009; 8:3149-56; PMID:19755849; http://dx.doi.org/10.4161/cc.8.19.9698.
    • (2009) Cell Cycle , vol.8 , pp. 3149-3156
    • Hohla, F.1    Buchholz, S.2    Schally, A.V.3    Seitz, S.4    Rick, F.G.5    Szalontay, L.6
  • 42
    • 79952743530 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia
    • PMID:21321192
    • Rick FG, Schally AV, Block NL, Nadji M, Szepeshazi K, Zarandi M, et al. Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia. Proc Natl Acad Sci USA 2011; 108:3755-60; PMID:21321192; http://dx.doi.org/10.1073/pnas.1018086108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3755-3760
    • Rick, F.G.1    Schally, A.V.2    Block, N.L.3    Nadji, M.4    Szepeshazi, K.5    Zarandi, M.6
  • 43
    • 84857137033 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases
    • PMID:22307626
    • Rick FG, Schally AV, Szalontay L, Block NL, Szepeshazi K, Nadji M, et al. Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases. Proc Natl Acad Sci USA 2012; 109:1655-60; PMID:22307626; http://dx.doi.org/10.1073/pnas.1120588109.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 1655-1660
    • Rick, F.G.1    Schally, A.V.2    Szalontay, L.3    Block, N.L.4    Szepeshazi, K.5    Nadji, M.6
  • 44
    • 79952774082 scopus 로고    scopus 로고
    • LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia
    • PMID:20945403
    • Rick FG, Schally AV, Block NL, Halmos G, Perez R, Fernandez JB, et al. LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. Prostate 2011; 71:736-47; PMID:20945403; http://dx.doi.org/10.1002/ pros.21289.
    • (2011) Prostate , vol.71 , pp. 736-747
    • Rick, F.G.1    Schally, A.V.2    Block, N.L.3    Halmos, G.4    Perez, R.5    Fernandez, J.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.