APOL1 variants in HIV-associated nephropathy: Just one piece of the puzzle

Kidney International

Volumn 82, Issue 3, 2012, Pages 259-260

  Hays, Thomas ^a   Wyatt, Christina M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOL1 GENE; DISEASE COURSE; DOWN REGULATION; FOCAL GLOMERULOSCLEROSIS; GENE; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HIV ASSOCIATED NEPHROPATHY; HUMAN; MYH9 GENE; NOTE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84863800344     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.129     Document Type: Note

References (10)

1. Kopp JB, Smith MW, Nelson GW et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet 2008; 40: 1175-1184.
2. Kao WH, Klag MJ, Meoni LA et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet 2008; 40: 1185-1192.
3. Genovese G, Friedman DJ, Ross MD et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 2010; 329: 841-845.
4. Kopp JB, Nelson GW, Sampath K et al. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 2011; 22: 2129-2137.
5. O'Seaghdha CM, Parekh RS, Hwang SJ et al. The MYH9/APOL1 region and chronic kidney disease in European-Americans. Hum Mol Genet 2011; 20: 2450-2456.
6. Johnstone DB, Zhang J, George B et al. Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy. Mol Cell Biol 2011; 31: 2162-2170.
7. Hays T, D'Agati VD, Garellek JA et al. Glomerular MYH9 expression is reduced by HIV-1. AIDS 2012; 26: 797-803.
8. Papeta N, Kiryluk K, Patel A et al. A POL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. J Am Soc Nephrol 2011; 22: 1991-1996.
9. Atta MG, Estrella MM, Kuperman M. HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics. Kidney Int 2012; 82: 338-343.
10. Fine DM, Wasser WG, Estrella MM et al. APOL1 risk variants predict histopathology and progression to ESRD in HIV-related kidney disease. J Am Soc Nephrol 2011; 23: 343-350.