Neurofilaments are flexible polymers that often fold and unfold, but they move in a fully extended configuration

Cytoskeleton

Volumn 69, Issue 7, 2012, Pages 535-544

  Taylor, Nicholas J ^a   Wang, Lina ^a,b   Brown, Anthony ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Axon; Axonal transport; Cytoskeleton; Intermediate filament; Motor protein; Neurofilament

Indexed keywords

NEUROFILAMENT M PROTEIN; POLYMER;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL FUNCTION; CELL MOTION; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; FLUORESCENCE MICROSCOPY; MICROFILAMENT; MICROTUBULE; MOLECULAR DYNAMICS; MOLECULAR IMAGING; MOTONEURON; MOUSE; NERVE CELL CULTURE; NERVE FIBER; NEUROFILAMENT; NEUROFILAMENT FOLDING; NEUROFILAMENT UNFOLDING; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AXONS; BIOPOLYMERS; CELLS, CULTURED; MICE; NEUROFILAMENT PROTEINS; NEURONS; PROTEIN FOLDING;

EID: 84863785565     PISSN: 19493584     EISSN: 19493592     Source Type: Journal    
DOI: 10.1002/cm.21039     Document Type: Article

References (35)

1. Beck R, Deek J, Choi MC, Ikawa T, Watanabe O, Frey E, Pincus P, Safinya CR. 2010. Unconventional salt trend from soft to stiff in single neurofilament biopolymers. Langmuir 26: 18595-18599.
2. Bednar J, Furrer P, Katritch V, Stasiak AZ, Dubochet J, Stasiak A. 1995. Determination of DNA persistence length by cryo-electron microscopy. Separation of the static and dynamic contributions to the apparent persistence length of DNA. J Mol Biol 254: 579-594.
3. Boal DH. 2012. Mechanics of the Cell. New York: Cambridge University Press. 608 p.
4. Brown A. 2000. Slow axonal transport: stop and go traffic in the axon. Nat Rev Mol Cell Biol 1: 153-156.
5. Brown A, Slaughter TS, Black MM. 1992. Newly assembled microtubules are concentrated in the proximal and distal regions of growing axons. J Cell Biol 119: 867-882.
6. Colakoglu G, Brown A. 2009. Intermediate filaments exchange subunits along their length and elongate by end-to-end annealing. J Cell Biol 185: 769-777.
7. Coleman TR, Lazarides E. 1992. Continuous growth of vimentin filaments in mouse fibroblasts. J Cell Sci 103 ( Pt 3): 689-698.
8. Dalhaimer P, Wagner OI, Leterrier J-F, Janmey PA, Aranda-Espinoza H, Discher DE. 2005. Flexibility transitions and looped adsorption of wormlike chains. J Polym Sci Part B: Polym Phys 43: 280-286.
9. Francis F, Roy S, Brady ST, Black MM. 2005. Transport of neurofilaments in growing axons requires microtubules but not actin filaments. J Neurosci Res 79: 442-450.
10. Gittes F, Mickey B, Nettleton J, Howard J. 1993. Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape. J Cell Biol 120: 923-934.
11. Gouveia SM, Akhmanova A. 2010. Cell and molecular biology of microtubule plus end tracking proteins: end binding proteins and their partners. Int Rev Cell Mol Biol 285: 1-74.
12. He Y, Francis F, Myers KA, Yu W, Black MM, Baas PW. 2005. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. J Cell Biol 168: 697-703.
13. Helfand BT, Loomis P, Yoon M, Goldman RD. 2003. Rapid transport of neural intermediate filament protein. J Cell Sci 116: 2345-2359.
14. Herrmann H, Aebi U. 2004. Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular scaffolds. Annu Rev Biochem 73: 749-789.
15. Hinman LE, Sammak PJ. 1998. Intensity modulation of pseudocolor images. Biotechniques 25: 124-128.
16. Jung C, Lee S, Ortiz D, Zhu Q, Julien JP, Shea TB. 2005. The high and middle molecular weight neurofilament subunits regulate the association of neurofilaments with kinesin: inhibition by phosphorylation of the high molecular weight subunit. Brain Res Mol Brain Res 141: 151-155.
17. Kaech S, Banker G. 2006. Culturing hippocampal neurons. Nat Protocols 1: 2406-2415.
18. Lasek RJ, Paggi P, Katz MJ. 1992. Slow axonal transport mechanisms move neurofilaments relentlessly in mouse optic axons. J Cell Biol 117: 607-616.
19. Mitchell CS, Lee RH. 2009. A quantitative examination of the role of cargo-exerted forces in axonal transport. J Theoret Biol 257: 430-437.
20. Ngai J, Coleman TR, Lazarides E. 1990. Localization of newly synthesized vimentin subunits reveals a novel mechanism of intermediate filament assembly. Cell 60: 415-427.
21. Perrot R, Berges R, Bocquet A, Eyer J. 2008. Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration. Mol Neurobiol 38: 27-65.
22. Prahlad V, Helfand BT, Langford GM, Vale RD, Goldman RD. 2000. Fast transport of neurofilament protein along microtubules in squid axoplasm. J Cell Sci 113: 3939-3946.
23. Shah JV, Flanagan LA, Janmey PA, Leterrier J-F. 2000. Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol Biol Cell 11: 3495-3508.
24. Shubeita GT, Tran SL, Xu J, Vershinin M, Cermelli S, Cotton SL, Welte MA, Gross SP. 2008. Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets. Cell 135: 1098-1107.
25. Uchida A, Brown A. 2004. Arrival, reversal and departure of neurofilaments at the tips of growing axons. Mol Biol Cell 15: 4215-4225.
26. Uchida A, Alami NH, Brown A. 2009. Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilaments. Mol Biol Cell 20: 4997-5006.
27. Vikstrom KL, Lim S-S, Goldman RD, Borisy GG. 1992. Steady state dynamics of intermediate filament networks. J Cell Biol 118: 121-129.
28. Wagner OI, Lifshitz J, Janmey PA, Linden M, McIntosh TK, Leterrier JF. 2003. Mechanisms of mitochondria-neurofilament interactions. J Neurosci 23: 9046-9058.
29. Wagner OI, Ascano J, Tokito M, Leterrier JF, Janmey PA, Holzbaur EL. 2004. The interaction of neurofilaments with the microtubule motor cytoplasmic dynein. Mol Biol Cell 15: 5092-5100.
30. Wagner OI, Rammensee S, Korde N, Wen Q, Leterrier JF, Janmey PA. 2007. Softness, strength and self-repair in intermediate filament networks. Exp Cell Res 313: 2228-2235.
31. Wang L, Brown A. 2010. A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport. Mol Neurodegener 5: 52.
32. Wang L, Ho C-L, Sun D, Liem RKH, Brown A. 2000. Rapid movement of axonal neurofilaments interrupted by prolonged pauses. Nat Cell Biol 2: 137-141.
33. Xia CH, Roberts EA, Her LS, Liu X, Williams DS, Cleveland DW, Goldstein LS. 2003. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol 161: 55-66.
34. Yabe JT, Jung CW, Chan WKH, Shea TB. 2000. Phospho-dependent association of neurofilament proteins with kinesin in situ. Cell Motil Cytoskeleton 45: 249-262.
35. Yan Y, Jensen K, Brown A. 2007. The polypeptide composition of moving and stationary neurofilaments in cultured sympathetic neurons. Cell Motil Cytoskeleton 64: 299-309.