Transport of neurofilaments in growing axons requires microtubules but not actin filaments

Journal of Neuroscience Research

Volumn 79, Issue 4, 2005, Pages 442-450

  Francis, Franto ^a   Roy, Subhojit ^b   Brady, Scott T ^c   Black, Mark M ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Actin filaments; Axons; Microtubules; Nerofilament transport; Neurofilaments

Indexed keywords

GREEN FLUORESCENT PROTEIN; LATRUNCULIN; MARINE TOXIN; MOLECULAR MOTOR; NOCODAZOLE; POLYMER; UNCLASSIFIED DRUG; VINBLASTINE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPOLYMERIZATION; IMAGING SYSTEM; MICROTUBULE; NERVE CELL CULTURE; NERVE FIBER GROWTH; NERVE FIBER TRANSPORT; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TIME;

EID: 14144253761     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20399     Document Type: Article

References (31)

1. Baas PW, Black MM. 1990. Individual microtubules of the axon consist of distinct domains that differ in stability and composition. J Cell Biol 111:494-509.
2. Baas PW, Brown A, Slaughter T, Black MM. 1991. Microtubule dynamics in axons and dendrites. J Neurosci Res 30:134-153.
3. Black MM, Kurdyla J. 1983. Microtubule-associated proteins of neurons. J Cell Biol 97:1020-1028.
4. Black MM, Slaughter T, Moshiach S, Obrocka M, Fischer I. 1996. Tau is enriched on dynamic microtubules in the distal region of growing axons. J Neurosci 16:3601-3619.
5. Blose SH, Meltzer DI, Feramisco JR. 1984. 10-nm Filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin. J Cell Biol 98:847-858.
6. Brady ST, Lasek RJ, Allen RD, Yin HL, Stossel TP. 1984. Gelsolin inhibition of fast axonal transport indicates a requirement for actin filaments. Nature 310:56-58.
7. Brown A. 2000. Slow axonal transport: stop and go traffic in the axon. Nat Rev Mol Cell Biol 1:153-156.
8. Brown A, Slaughter T, Black MM. 1992. Newly assembled microtubules are concentrated in the proximal and distal regions of growing axons. J Cell Biol 119:867-882.
9. Dennerll TJ, Joshi HC, Steel VL, Buxbaum RE, Heidemann SR. 1988. Tension and compression in the cytoskeleton of PC-12 neurites II: quantitative measurements. J Cell Biol 107:665-674.
10. Dustin P. 1984. Microtubules. Berlin: Springer-Verlag.
11. Elluru R, Bloom GS, Brady ST. 1995. Fast axonal transport of kinesin in the rat visual system: functionality of the kinesin heavy chain isoforms. Mol Biol Cell 6:21-40.
12. He Y, Francis F, Myers KA, Yu W, Black MM, Baas PW. 2005. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. Submitted for publication.
13. Helfand BT, Chang L, Goldman RD. 2003a. The dynamic and motile properties of intermediate filaments. Annu Rev Cell Dev Biol 19:445-467.
14. Helfand BT, Loomis P, Yoon M, Goldman RD. 2003b. Rapid transport of neural intermediate filament protein. J Cell Sci 116:2345-2359.
15. Huang JD, Brady ST, Richards BW, Stenolen D, Resau JH, Copeland NG, Jenkins NA. 1999. Direct interaction of microtubule- and actin-based transport motors. Nature 397:267-270.
16. Lalli G, Gschmeissner S, Schiavo G. 2003. Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons. J Cell Sci 116:4639-4650.
17. Langford GM. 2002. Myosin-V, a versatile motor for short-range vesicle transport. Traffic 3:859-865.
18. Nascimento AA, Roland JT, Gelfand VI. 2003. Pigment cells: a model for the study of organelle transport. Annu Rev Cell Dev Biol 19:469-491.
19. Prahlad V, Helfand BT, Langford GM, Vale RD, Goldman RD. 2000. Fast transport of neurofilament protein along microtubules in squid axoplasm. J Cell Sci 113:3939-3946.
20. Rao MV, Engle LJ, Mohan PS, Yuan A, Qiu D, Cataldo A, Hassinger L, Jacobsen S, Lee VM, Andreadis A, Julien JP, Bridgman PC, Nixon RA. 2002. Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol 159:279-290.
21. Roy S, Coffee P, Smith G, Liem RKH, Brady ST, Black MM. 2000. Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport. J Neurosci 20:6849-6861.
22. Shah JV, Flanagan LA, Janmey PA, Leterrier JF. 2000. Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol Biol Cell 11:3495-3508.
23. Shea TB, Flanagan LA. 2001. Kinesin, dynein and neurofilament transport. Trends Neurosci 24:644-648.
24. Slaughter T, Wang J, Black MM. 1997. Microtubule transport from the cell body into the axons of growing neurons. J Neurosci 17:5807-5819.
25. Szebenyi G, Smith GM, Li P, Brady ST. 2002. Overexpression of neurofilament H disrupts normal cell structure and function. J Neurosci Res 68:185-198.
26. Tint I, Slaughter T, Fischer I, Black MM. 1998. Acute inactivation of tau has no effect on dynamics of microtubules in growing axons of cultured sympathetic neurons. J Neurosci 18:8660-8673.
27. Tsai M-Y, Morfini G, Szebenyi G, Brady ST. 2000. Modulation of kinesin-vesicle interactions by Hsc70: implications for regulation of fast axonal transport. Mol Biol Cell 11:2161-2173.
28. Wang L, Brown A. 2001. Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching. Mol Biol Cell 12:3257-3267.
29. Wang L, Ho CL, Sun D, Liem RKH, Brown A. 2000. Rapid movement of axonal neurofilaments interrupted by prolonged pauses. Nat Cell Biol 2:137-141.
30. Xia CH, Roberts EA, Her LS, Liu X, Williams DS, Cleveland DW, Goldstein LS. 2003. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol 161:55-66.
31. Yvon A-M, Gross DJ, Wadsworth P. 2001. Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells. Proc Natl Acad Sci U S A 98:8656-8661.