A comparison of in vitro relaxant responses to ipratropium bromide, β-adrenoceptor agonists and theophylline in feline bronchial smooth muscle

Veterinary Journal

Volumn 193, Issue 1, 2012, Pages 228-233

  Leemans, Jérôme ^a,b   Kirschvink, Nathalie ^b   Gustin, Pascal ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF NAMUR   (Belgium)

Author keywords

Bronchodilators; Cat; Functional antagonism; Isolated bronchial smooth muscle

Indexed keywords

ACETYLCHOLINE; AMINOPHYLLINE; FENOTEROL; FORMOTEROL; IPRATROPIUM BROMIDE; ISOPRENALINE; SALBUTAMOL; SALMETEROL; THEOPHYLLINE;

ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS MUSCLE; BRONCHUS TONE; CAT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; IN VITRO STUDY; NONHUMAN;

ADRENERGIC BETA-AGONISTS; ANIMALS; BRONCHI; BRONCHODILATOR AGENTS; CATS; CHOLINERGIC ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IPRATROPIUM; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; THEOPHYLLINE;

FELIDAE;

EID: 84863784084     PISSN: 10900233     EISSN: 15322971     Source Type: Journal    
DOI: 10.1016/j.tvjl.2011.10.026     Document Type: Article

References (28)

1. Coulson F.R., Fryer A.D. Muscarinic acetylcholine receptors and airway diseases. Pharmacology and Therapeutics 2003, 98:59-69.
2. Diamond L., O'Donnell M. A comparative study of two parasympatholytic bronchodilator agents: Ipratropium bromide and diphemanil methylsulfate. Journal of Pharmacology and Experimental Therapeutics 1981, 216:1-5.
3. Dye J.A., McKiernan B.C., Jones S.D., Neff-Davis C.A., Koritz G.D. Sustained-release theophylline pharmacokinetics in the cat. Journal of Veterinary Pharmacology and Therapeutics 1989, 12:133-140.
4. Ehlert F.J. Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life Sciences 2003, 74:355-366.
5. Finney M.J., Karlsson J.A., Persson C.G. Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. British Journal of Pharmacology 1985, 85:29-36.
6. Guenther-Yenke C.L., McKiernan B.C., Papich M.G., Powell E. Pharmacokinetics of an extended-release theophylline product in cats. Journal of the American Veterinary Medical Association 2007, 231:900-906.
7. Karlsson J.A., Persson C.G. Influence of tracheal contraction on relaxant effects in vitro of theophylline and isoprenaline. British Journal of Pharmacology 1981, 74:73-79.
8. Kirschvink N., Leemans J., Delvaux F., Snaps F., Clercx C., Gustin P. Functional, inflammatory and morphological characterisation of a cat model of allergic airway inflammation. The Veterinary Journal 2007, 174:541-553.
9. Leemans J., Kirschvink N., Bernaerts F., Clercx C., Cambier C., Gustin P. A pilot study comparing the antispasmodic effects of inhaled salmeterol, salbutamol and ipratropium bromide using different aerosol devices on muscarinic bronchoconstriction in healthy cats. The Veterinary Journal 2009, 180:236-245.
10. Leemans J., Kirschvink N., Clercx C., Cambier C., Gustin P. Functional response to inhaled salbutamol and/or ipratropium bromide in Ascaris suum-sensitised cats with allergen-induced bronchospasms. The Veterinary Journal 2010, 186:76-83.
11. Leemans, J., Kirschvink, N., Bernaerts, F., Clercx, C., Snaps, F., Billen, F., Gustin, P., 2011. Salmeterol or doxycycline do not inhibit acute bronchospasm and airway inflammation in cats with experimentally-induced asthma. The Veterinary Journal, accepted for publication.
12. Lemoine H., Overlack C. Highly potent beta-2 sympathomimetics convert to less potent partial agonists as relaxants of guinea pig tracheae maximally contracted by carbachol. Comparison of relaxation with receptor binding and adenylate cyclase stimulation. Journal of Pharmacology and Experimental Therapeutics 1992, 261:258-270.
13. Linden A., Bergendal A., Ullman A., Skoogh B.E., Lofdahl C.G. Salmeterol, formoterol, and salbutamol in the isolated guinea pig trachea: Differences in maximum relaxant effect and potency but not in functional antagonism. Thorax 1993, 48:547-553.
14. Lulich K.M., Mitchell H.W., Sparrow M.P. The cat lung strip as an in vitro preparation of peripheral airways: A comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. British Journal of Pharmacology 1976, 58:71-79.
15. Matsui M., Griffin M.T., Shehnaz D., Taketo M.M., Ehlert F.J. Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice. Journal of Pharmacology and Experimental Therapeutics 2003, 305:106-113.
16. McKiernan B.C., Koritz G.D., Davis L.E., Neff-Davis C.A., Pheris D.R. Pharmacokinetic studies of theophylline in cats. Journal of Veterinary Pharmacology and Therapeutics 1983, 6:99-104.
17. Mitchell R.W., Ndukwu I.M., Leff A.R., Padrid P.A. Muscarinic hyperresponsiveness of antigen-sensitized feline airway smooth muscle in vitro. American Journal of Veterinary Research 1997, 58:672-676.
18. Molimard M., Naline E., Zhang Y., Le G.V., Begaud B., Advenier C. Long- and short-acting beta2 adrenoceptor agonists: Interactions in human contracted bronchi. European Respiratory Journal 1998, 11:583-588.
19. Naline E., Zhang Y., Qian Y., Mairon N., Anderson G.P., Grandordy B., Advenier C. Relaxant effects and durations of action of formoterol and salmeterol on the isolated human bronchus. European Respiratory Journal 1994, 7:914-920.
20. Naline E., Trifilieff A., Fairhurst R.A., Advenier C., Molimard M. Effect of indacaterol, a novel long-acting beta2-agonist, on isolated human bronchi. European Respiratory Journal 2007, 29:575-581.
21. O'Donnell S.R., Wanstall J.C. Relaxation of cat trachea by beta-adrenoceptor agonists can be mediated by both beta1- and beta2-adrenoceptors and potentiated by inhibitors of extraneuronal uptake. British Journal of Pharmacology 1983, 78:417-424.
22. Ostrom R.S., Ehlert F.J. Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea. Journal of Pharmacology and Experimental Therapeutics 1999, 288:969-976.
23. Padrid P. Use of inhaled medications to treat respiratory diseases in dogs and cats. Journal of the American Animal Hospital Association 2006, 42:165-169.
24. Padrid P., Snook S., Finucane T., Shiue P., Cozzi P., Solway J., Leff A.R. Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats. American Journal of Respiratory and Critical Care Medicine 1995, 151:184-193.
25. Palmqvist M., Ibsen T., Mellen A., Lotvall J. Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients. American Journal of Respiratory and Critical Care Medicine 1999, 160:244-249.
26. Ranivand, L., Otto, C.M., 2008. Feline asthma trends in philadelphia, Pennsylvania 1986-2007. In: Proceedings: 26th Symposium of the Veterinary Comparative Respiratory Society, Oklahoma City (OK), USA.
27. Torphy T.J. Differential relaxant effects of isoproterenol on methacholine- versus leukotriene D4-induced contraction in the guinea-pig trachea. European Journal of Pharmacology 1984, 102:549-553.
28. Torphy T.J., Rinard G.A., Rietow M.G., Mayer S.E. Functional antagonism in canine tracheal smooth muscle: Inhibition by methacholine of the mechanical and biochemical responses to isoproterenol. Journal of Pharmacology and Experimental Therapeutics 1983, 227:694-699.