Timing of insulin therapy affects the inflammatory response in endotoxemic rats

Inflammation

Volumn 35, Issue 2, 2012, Pages 723-729

  Zou, Bo ^a   Chen, Qiyi ^a   Tang, Shaoqiu ^a   Gao, Tao ^b   Zhang, Juanjuan ^b   Xi, Fengchan ^b   Yu, Wenkui ^b  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING GENERAL HOSPITAL OF NANJING MILITARY COMMAND   (China)

Author keywords

Anti inflammatory cytokine; Endotoxin; Insulin; Proinflammatory cytokine; Timing of therapy

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BERLININSULIN H; CALCIUM; GLUCOSE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOPHANE INSULIN; PHOSPHATE; POTASSIUM; SODIUM; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSAGE SCHEDULE COMPARISON; DOWN REGULATION; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; LIVER LEVEL; MALE; NONHUMAN; PROTEIN EXPRESSION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TIME; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG ADMINISTRATION SCHEDULE; ENDOTOXEMIA; INFLAMMATION; INSULIN; INTERLEUKIN-10; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 84863777087     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-011-9367-8     Document Type: Article

References (20)

1. van den Berghe, G., et al. 2001. Intensive insulin therapy in the critically ill patients. The New England Journal of Medicine 345 (19): 1359-1367.
2. Van den Berghe, G., et al. 2006. Intensive insulin therapy in the medical ICU. The New England Journal of Medicine 354(5): 449-461.
3. Brunkhorst, F.M., et al. 2008. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. The New England Journal of Medicine 358(2): 125-139.
4. Finfer, S., et al. 2009. Intensive versus conventional glucose control in critically ill patients. The New England Journal of Medicine 360(13): 1283-1297.
5. Viardot, A., et al. 2007. Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype. Endocrinology 148(1): 346-353. (Pubitemid 46021467)
6. Jeschke, M.G., et al. 2004. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology 145(9): 4084-4093. (Pubitemid 39120556)
7. Honiden, S., et al. 2008. Early versus late intravenous insulin administration in critically ill patients. Intensive Care Medicine 34 (5): 881-887. (Pubitemid 351571187)
8. Langouche, L., et al. 2007. Effect of intensive insulin therapy on insulin sensitivity in the critically ill. Journal of Clinical Endocrinology and Metabolism 92(10): 3890-3897. (Pubitemid 47607638)
9. Osuchowski, M., et al. 2006. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. The Journal of Immunology 177(3): 1967.
10. Van den Berghe, G., et al. 2003. Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Critical Care Medicine 31(2): 359-366.
11. Zanotti, S., and A. Kumar. 2002. Cytokine modulation in sepsis and septic shock. Expert Opinion on Investigational Drugs 11(8): 1061.
12. Casey, L., R. Balk, and R. Bone. 1993. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Annals of Internal Medicine 119(8): 771.
13. Jeschke, M.G., et al. 2005. Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats. Journal of Hepatology 42(6): 870-879. (Pubitemid 40693204)
14. Frink, M., et al. 2009. IL-6 predicts organ dysfunction and mortality in patients with multiple injuries. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 17: 49.
15. Rau, S., et al. 2007. Plasma interleukin 6 response is predictive for severity and mortality in canine systemic inflammatory response syndrome and sepsis. Veterinary Clinical Pathology 36(3): 253-260. (Pubitemid 351761830)
16. Barkhausen, T., et al. 2009. Insulin therapy induces changes in the inflammatory response in a murine 2-hit model. Injury 40(8): 806-814.
17. Debets, J., and R. Kampmeijer. 1989. Plasma tumor necrosis factor and mortality in critically ill septic patients. Critical Care Medicine 17(6): 489.
18. Leonidou, L., et al. 2007. Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia. Journal of Infection 55(4): 340-346. (Pubitemid 47376575)
19. de Luca, C., and J. Olefsky. 2008. Inflammation and insulin resistance. FEBS Letters 582(1): 97-105. (Pubitemid 50010731)
20. Fram, R., et al. 2010. Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children*. Critical Care Medicine 38(6): 1475.