Determination of non-steroidal anti-inflammatory drugs and their metabolites in milk by liquid chromatography-tandem mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 403, Issue 10, 2012, Pages 2955-2963

  Jedziniak, Piotr ^a   Szprengier Juszkiewicz, Teresa ^a   Pietruk, Konrad ^a   Ledziska, Edyta ^a   Żmudzki, Jan ^a  

^a NATIONAL VETERINARY RESEARCH INSTITUTE   (Poland)

Author keywords

Diclofenac; Drugs in milk; Metamizole; Non steroidal anti inflammatory drugs

Indexed keywords

BIOMOLECULES; HEALTH RISKS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

COMMISSION DECISION 2002/657/EC; DICLOFENAC; DRUGS IN MILK; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; METAMIZOLE; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; REPRODUCIBILITIES; SIMULTANEOUS DETERMINATIONS;

DRUG PRODUCTS;

ANIMALIA;

EID: 84863775988     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-5860-7     Document Type: Article

References (19)

1. Commission Regulation 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Off J Eur Union L15:1-71
2. Council Directive 96/23/EC of 29 April 1996 on measures to monitor certain substances and residues thereof in live animals and animal products and repealing Directives 85/ 358/EEC and 86/469/EEC and Decisions 89/187/EEC and 91/664/EEC. Off JEur Commun. L125
3. Gallo P, Fabbrocino S, Vinci F, Fiori M, Danese V, Serpe L (2008) Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry. Rapid Commun Mass Spectrom 22:841-54
4. Gallo P, Fabbrocino S, Dowling G, Salini M, Fiori M, Perretta G, Serpe L (2010) Confirmatory analysis of non-steroidal anti-inflammatory drugs in bovine milk by high-performance liquid chromatography with fluorescence detection. J Chromatogr A 1217:2832-9
5. Dowling G, Gallo P, Malone E, Regan L (2009) Rapid confirmatory analysis of non-steroidal anti-inflammatory drugs in bovine milk by rapid resolution liquid chromatography tandem mass spectrometry. J Chromatogr A 1216:8117-31
6. Malone EM, Dowling G, Elliott CT, Kennedy DG, Regan L (2009) Development of a rapid, multi-class method for the confirmatory analysis of anti-inflammatory drugs in bovine milk using liquid chromatography tandem mass spectrometry. J Chromatogr A 1216:8132-40
7. Dowling G, Malone E, Harbison T, Martin S (2010) Analytical strategy for the determination of non-steroidal anti-inflammatory drugs in plasma and improved analytical strategy for the determination of authorized and non-authorized non-steroidal anti-inflammatory drugs in milk by LC-MS-MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:962-82
8. Dubreil-Chéneau E, Pirotais Y, Bessiral M, Roudaut B, Verdon E (2011) Development and validation of a confirmatory method for the determination of 12 non-steroidal anti-inflammatory drugs in milk using liquid chromatography-tandem mass spectrometry. J Chromatogr A 1218:6292-301
9. Stolker AA, Rutgers P, Oosterink E, Lasaroms JJ, Peters RJ, van Rhijn JA, Nielen MW (2008) Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. Anal Bioanal Chem 391:2309-22
10. Dowling G, Gallo P, Fabbrocino S, Serpe L, Regan L (2008) Determination of ibuprofen, ketoprofen, diclofenac and phenylbutazone in bovine milk by gas chromatography-tandem mass spectrometry. Food AdditContam Part A Chem Anal Control Expo Risk Assess 25:1497-508
11. Arroyo D, Ortiz MC, Sarabia LA (2011) Optimization of the derivatization reaction and the solid-phase microextraction conditions using a D-optimal design and three-way calibration in the determination of non-steroidal anti-inflammatory drugs in bovine milk by gas chromatography-mass spectrometry. J Chromatogr A 1218:4487-97
12. Azzouz A, Jurado-Sánchez B, Souhail B, Ballesteros E (2011) Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry. J Agric Food Chem 59:5125-5132
13. Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results (2002/657/EC). Off J Eur Commun L221:8-3
14. Dowling G, Gallo P, Regan L (2009) Confirmatory analysis of firocoxib in bovine milk by rapid resolution liquid chromatography tandem mass spectrometry. J Chromatogr B 877:541-546
15. Starek M (2011) Review of the applications of different analytical techniques for coxibs research. Talanta 85:8-27
16. Taylor PJ (2005) Matrix effects: The Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin Biochem 38:328
17. CRL Guidance Paper (7 December 2007) CRLs view on state of the art analytical methods for national residue control plans
18. Jedziniak P, Szprengier-Juszkiewicz T, Olejnik M, mudzki J (2010) Detemination of non-steroidal anti-inflammatory drugs residues in animal muscles by liquid chromatography - tandem mass spectrometry. Anal Chim Acta 672:85-92
19. Jedziniak P, Szprengier-Juszkiewicz T, Olejnik M (2009) Multiresidue screening method for determination of non-steroidal anti-inflammatory drugs residues in cow milk with HPLC-UV and its application to meloxicam residue depletion study. Bull Vet Inst Pulawy 53:731-739