Mucoadhesive polymers in ophthalmic drug delivery

Ophthalmic Drug Delivery Systems, Second Edition, Revised and Expanded

Volumn , Issue , 2003, Pages 409-435

  Johnston, Thomas P ^a   Dias, Clapton S ^a   Mitra, Ashim K ^a   Alur, Hemant ^b  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b Murty Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84863771118     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (92)

1. Harris, D., and Robinson, J. R. (1990). Bioadhesive polymers in peptide drug delivery, Biomaterial., 11: 652.
2. Schacter, H., and Williams, D. (1982). Biosynthesis of mucus glycoproteins, Adv. Exp. Med. Biol., 144: 3.
3. Marriot, C., and Gregory, N. P. (1990). Mucus physiology and pathology. In: Bioadhesive Drug Delivery Systems (V. Lenaerts and R. Gurny, eds.). CRC Press, Boca Raton, FL, p. 21.
4. Allen, A. (1981). The structure and function of gastrointestinal mucus. In: Basic Mechanisms of Gastrointestinal Mucosal Cell Injury and Protection (J. W. Harmon, ed.). Williams & Wilkins, Baltimore, p. 351.
5. Allen, A., and Carrol, N. J. H. (1985). Adherent and soluble mucus in the stomach and duodenum, Dig. Dis. Sci., 30: 55s.
6. Gandhi, R. B., and Robinson, J. R. (1988). Bioadhesion in drug delivery, Indian J. Pharm. Sci., 50: 145.
7. Marriot, C., and Hughes, D. R. L. (1989). Mucus physiology and pathology. In: Bioadhesion: Possibilities and Future Trends (R. Gurny and H. E. Junginger, eds.). Wissenschaftliche Verlagsgesellschaft, Stuttgart, p. 29.
8. Johnson, P. M., and Rainsford, K. D. (1978). The physical properties of mucus: Preliminary observations on the sedimentation behavior of porcine gastric mucus, Biochim. Biophys. Acta, 286: 72.
9. Phelps, C. F. (1978). Biosynthesis of mucus glycoproteins, Br. Med. Bull., 34: 43.
10. Robinson, J. R. (1989). Ocular drug delivery. Mechanism(s) of corneal drug transport and mucoadhesive delivery systems, S.T.P. Pharm., 5: 839.
11. Mikos, A. G., and Peppas, N. A. (1986). Systems for controlled release of drug. V. Bioadhesive systems, S.T.P. Pharm., 2: 705.
12. Dedaguin, B. V., Toporov, Y. P., Mueler, V. M., and Aleinikova, I. N. (1977). On the relationship between the electrostatic and the molecular component of the adhesion of elastic particles to a solid surface. J. Colloid Interface Sci., 58: 528.
13. Baier, R.E., Shafrin, I.G., and Zisman, W.A. (1968). Adhesion: Mechanism that assist and impede it, Scienc., 162: 1360.
14. Helfand, E., and Tagami, Y. (1971). Theory of the interface between immiscible polymers, Polym. Lett., 9: 741.
15. Helfand, E., and Tagami, Y. (1972). Theory of the interface between immiscible polymers. II. J. Chem. Phys., 56: 3592.
16. Helfand, E., and Tagami, Y. (1972). Theory of the interface between immiscible polymers, J. Chem. Phys., 57: 1812.
17. Peppas, N. A., and Buri, P. A. (1985). Surface, interfacial and molecular aspects of polymer adhesion on soft tissues, J. Controlled Release, 2: 257.
18. Peppas, N. A., and Lustig, B. R. (1985). The role of crosslinks, entanglements, and relaxations of the macromolecular carrier in the diffusional release of biologically active materials: Conceptual and scaling relationships, Ann. NY Acad. Sci., 446: 26.
19. Reinhart, C. T., and Peppas, N. A. (1984). Solute diffusion in swollen membranes. II. Influence of crosslinking on diffusive properties. J. Membr. Sci., 18: 227.
20. Peppas, N. A., and Reinhart, C. T. (1983). Solute diffusion in swollen membranes. Part I. New therapy, J. Membr. Sci., 15: 275.
21. Tabor, D. J. (1977). Surface forces and surface interactions, J. Colloid Interface Sci., 58: 2.
22. Kinloch, A. J. (1980). The science of adhesion: I. Surface and interfacial aspects, J. Mater. Sci., 15: 2141.
23. Good, R. J. (1977). Surface free energy of solids and liquids: Thermodynamics, molecular forces and structure, J. Colloid Interface Sci., 58: 398.
24. Ponchel, G., Touchard, F., Duchene, D., and Peppas, N. A. (1987). Bioadhesive analysis of controlled release systems. I. Fracture and interpenetration analysis in poly(acrylic acid) containing systems, J. Controlled Release, 5: 129.
25. Mikos, A. G., and Peppas, N. A. (1988). Polymer chain entanglements and brittle fracture, J. Chem. Phys., 88: 1337.
26. Wake, W. C. (1976). Theories of adhesion and adhesive action. In: Adhesion and Formulation of Adhesives.Applied Science, London, p. 65.
27. Israelachvili, J. N. (1985). Intermolecular and Surface Forces.Academic Press, New York.
28. Pritchard, W. H. (1971). The role of hydrogen bonding in adhesion, Aspects Adhes., 6: 11.
29. Colo, G. D., Bugalassi, S., Chetoni, P., Fiaschi, M. P., Zambito, Y. and Sattone, M. F. (2001). Relevance of polymer molecular weight to the in vitro/in vivo performances of ocular inserts based on poly(ethylene oxide), Int. J. Pharmaceutic., 220: 169.
30. Park, H., and Robinson, J. R. (1985). Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion, J. Controlled Releas., 2: 47.
31. Nagai, T., and Machida, Y. (1985). Advances in drug delivery. Mucosal adhesive dosage forms, Pharma. Int. Engl. Ed., August: 196.
32. Satoh, K., Takayama, K., Machida, Y., Suzuki, Y., Nakagaki, M., and Nagai, T. (1989). Factors affecting the bioadhesive properties of tablets consisting of hydroxypropyl cellulose and carboxy vinyl polymers, Chem. Pharm. Bul., 37: 1366.
33. Gottschalk, A. (1960). In: The Chemistry and Biology of Sialic Acid and Related Substances. Cambridge University Press, London.
34. Leonard, F., Hodge, J. W., Jr., Houston, S., and Ousterhout, D. K. (1968). Alpha cyanoacrylate adhesive bond strengths with proteinaceous and non proteinaceous substances, J. Biomed. Mater. Res., 2: 173.
35. Smart, J. D., Kellaway, I. W., and Worthington, H. E. C. (1984). An in vitro investigation of mucosal adhesive materials for use in controlled drug delivery, J. Pharm. Pharmacol., 36: 295.
36. Leung, S. H. S., and Robinson, J. R. (1990). Polymer structure features contributing to mucoadhesion. II., J. Controlled Releas., 12: 187.
37. Chen, J. L., and Cyr, G. N. (1970). Compositions producing adhesion through adhesion. In: Adhesive Biological Systems (R. S. Manly, ed.). Academic Press, New York, p. 78.
38. Smart, J. D. (1991). An in vitro assessment of some muco-adhesive dosage forms, Int. J. Pharm., 73: 69.
39. Park, K., and Park, H. (1990). Test methods of bioadhesion. In: Bioadhesive Drug Delivery Systems (V. Lenaerts and R. Gurny, eds.). CRC Press, Boca Raton, FL, p. 43.
40. Wang, P. Y., and Forrester, D. H. (1974). Conditions for the induced adhesion of hydrophobic polymers to soft tissue, Trans. Am. Soc. Artif. Int. Organ., 20: 504.
41. Teng, C. L. C., and Ho, N. F. L. (1987). Mechanistic studies in the simultaneous flow and adsorption of polymer coated latex particles on intestinal mucus. I: Methods and physical model development, J. Controlled Release, 6: 133.
42. Zaki, I., Fitzgerald, P., Hardy, J. G., and Wilson, C. G. (1986). A comparison of the effect of viscosity in the precorneal residence of solutions in rabbit and man, J. Pharm. Pharmacol., 38: 463.
43. Moss, R. A. (1987). The eyelids. In: Adler’s Physiology of the Eye: Clinical Application., 8th ed. (R. A. Moses and W. M. Hart, Jr., eds.). Mosby, St. Louis, p. 1.
44. Saettone, M. F., Giannaccinni, B., Guiducci, A., LaMarca, F., and Tota, G. (1985). Polymer effects on ocular bioavailability. II: The influence of benzalk-onium chloride on the mydriatic response of tropicamide in different polymeric vehicles, Int. J. Pharm., 25: 73.
45. Wright, P., and Mackie, I. A. (1977). Mucus in healthy and diseased eye, Trans. Ophthalmol. Soc. U., 91: 1.
46. Hardy, J. G., Lee, S. W., and Wilson, C. G. (1985). Intranasal drug delivery by sprays and drops, J. Pharm. Pharmacol., 37: 294.
47. Tabachnik, N. F., Blackburn, P., and Cerami, A. (1981). Biochemical and rheological characteristics of sputum mucus from a patients with cystic fibrosis, J. Biol. Chem., 256: 7161.
48. Swan, K. C. (1945). Use of methylcellulose in ophthalmology, Arch. Ophthalmol., 33: 378.
49. Mueller, W. H., and Deardorff, D. L. (1956). Ophthalmic vehicles: The effect of methylcellulose on the penetration of Homatropine hydrobromide through the cornea, J. Am. Pharm. Assoc., 45: 334.
50. Oechsner, M., and Keipert, S. (1999). Polyacrylic acid/polyvinylpyrrolidone biopolymeric systems. I. Rheological and mucoadhesive properties of formulations potentially useful for the treatment of dry-eye syndrome, Eur. J. Pharm. Biopharm., 47: 113-118.
51. Saettone, M. F., Giannaccinni, B., Ravecca, S., La Marca, F., and Tota, G. (1984). Polymer effects of ocular bioavailability: The influence of different liquid vehicles on the mydriatic response of tropicamide in humans and in rabbits, Int. J. Pharm., 20: 187.
52. Benedetto, D. A., Shah, D. O., and Kaufman, H. E. (1975). Instilled fluid dynamics and surface chemistry of polymers in the preocular tear film, Invest. Ophthalmol., 14: 887.
53. Davies, N. M., Farr, S. J., Hadgraft, J., and Kellaway, I. W. (1991). Evaluation of mucoadhesive polymers in ocular drug delivery. I. Viscous solutions, Pharm. Res., 8: 1039-1043.
54. Huupponen, R., Kaila, T., Saettone, M. F., Monti, D., Iisalo, E., Salminen, L., and Oksala, O. (1992). The effect of some macromolecular ionic complexes on the pharmacokinetics and dynamics of ocular cyclopentolate in rabbits, J. Ocular Pharmacol., 8: 59-67.
55. Hui, H. W., and Robinson, J. R. (1985). Ocular delivery of progesterone using a bioadhesive polymer, Int. J. Pharm., 26: 203.
56. Saettone, M. F., Chetoni, P., Torracca, M. T., Burgalassi, S., and Giannaccinni, B. (1989). Evaluation of mucoadhesive properties and in vivo activity of ophthalmic vehicles based on hyaluronic acid, Int. J. Pharm., 51: 203.
57. Saettone, M. F., Giannaccini, B., Chetoni, P., Galli, G., and Chiellini, E. (1984). Vehicle effects on the ophthalmic bioavailability: An evaluation of polymeric inserts containing pilocarpine, J. Pharm. Pharmacol., 36: 229.
58. Chetoni, P., Di Colo, G., Grandi, M., Morelli, M., Saettone, M. F., and Darougar, S. (1998). Silicone rubber/hydrogel composite ophthalmic inserts: Preparation and preliminary in vitro/in vivo evaluation, Eur. J. Pharm. Biopharm., 46: 125-132.
59. Finne, U., Salivirta, J., and Urtti, A. (1991). Sodium acetate improves the ocular/systemic absorption ratio of timolol applied ocularly in monoisopropyl PVM-MA matrices, Int. J. Pharm., 75: R1.
60. Losa, C., Calvo, P., Castro, E., Vila-Jato, J. L., and Alono, M. J. (1991). Improvement of ocular penetration of amikacin sulphate by association to poly(butylcyanoacrylate) nanoparticles, J. Pharm. Pharmacol., 43: 548.
61. Vanderhoff, J., El-Asser, E. R., and Urgerstad, J. (1977). U.S. Patent Application #867031.
62. Kumar, S., Haglund, B. O., and Himmelstein, K. J. (1994). In situ-forming gels for opthalmic drug delivery, J. Ocular Pharmacol.10: 47.
63. Davies, N. M., Farr, S. J., Hadgraft, J., and Kellaway, I. W. (1992). Evaluation of mucoadhesive polymers in ocular drug delivery. II. Polymer-coated vesicles, Pharm. Res., 9: 1137-1144.
64. Durrani, A. M., Farr, S. J., and Kellaway, I. W. (1995). Precorneal clearance of mucoadhesive microspheres from the rabbit eye, J. Pharm. Pharmacol., 47: 581-584.
65. Albasini, M., and Ludwig, A. (1995). Evaluation of polysaccharides intended for ophthalmic use in ocular dosage forms, Farmaco, 50: 633-642.
66. Lee, V. H. L., Li, S. Y., Sasaki, H., Saettone, M. F., and Chetoni, P. (1994). Influence of drug release rate on systemic timolol adsorption from polymeric occular inserts in the pigmented rabbit, J. Ocular. Pharmacol., 10: 421-429.
67. Das, S. K., Tucker, I. G., Hill, D. J. T., and Ganguly, N. (1995). Evaluation of poly(isobutylcyanoacrylate) nanoparticles for mucoadhesive ocular drug delivery. I. Effect of formulation variables on physicochemical characteristics of nanoparticles, Pharm. Res., 12: 534-540.
68. Robinson, J. R., and Li, V. H. K. (1984). Ocular disposition and bioavailability of pilocarpine from Piloplex® and other sustained release drug delivery systems. In: Recent Advances in Glaucoma (U. Ticho and R. David, eds.). Excerpta Medica, Amsterdam, p. 231.
69. Saettone, M. F., Giannaccinni, B., Guidicci, A., and Savigni, P. (1986). Semisolids ophthalmic vehicles. III. An evaluation of four organic hydrogels containing pilocarpine, Int. J. Pharm., 31: 261.
70. Joshi, A., Ding, S., and Himmelstein, K. J. Patent application U.S. 91/04104 (Publication No. WO 91/19481).
71. Kumar, S., and Himmelstein, K. J. (1995). Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose. J. Pharm. Sci., 84: 344.
72. Rozier, A., Mazuel, C., Grove, J., and Plazonnet, B. (1989). Gelrite: a novel, ion activated, in situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol, Int. J. Pharmaceutic., 57: 163.
73. Sanzigiri, Y. D., Maschi, S., Crescenzi, V., Callegaro, L., Topp, E. M., and Stella, V. J. (1993). Gellan-based systems for ophthalmic sustained delivery of methylprednisolone. J. Control Releas., 26: 195.
74. Alur, H. H., Pather, S. I., Mitra, A. K., and Johnston, T. P. (1999). Transmucosal delivery of chlorpheniramine maleate from a buccal tablet containing a natural, mucoadhesive gum, Int. J. Pharm., 188: 1-10.
75. Alur, H. H., Beal, J. D., Panther, S. I., Mitra, A. K., and Johnston, T. P. (1999). Evaluation of a novel, natural oligosaccharide gum as a sustained-release and mucoadhesive component of calcitonin buccal tablets, J. Pharm. Sc., 88: 1313-1319.
76. Alur, H. H., Pather, S. I., Mitra, A. K., and Johnston, T. P. (1999). Evaluation of the gum Hakea gibbosa as a sustained-release and mucoadhe-sive component in buccal tablets, Pharm. Develop. Technol., 4: 347-358.
77. Benditti, L. M., Kyyronen, K., Hume, L., Topp, E., and Stella, V. (1991). Steroid ester of hyaluronic acid in ophthalmic drug delivery, Proc. Int. Symp. Controlled Release Bioact. Mater., 18: 497.
78. Saettone, M. F., Giannaccinni, B., Torracca, M. T., and Burgalassi, S. (1987). An evaluation of the bioadhesive properties of hyaluronic acid. Proceedings of the 3rd Eur. Congress on Biopharm. Pharmacokinetics, Vol. 1, Freiburg, April, p. 413.
79. Saettone, M. F., Chetoni, P., Torracca, M. T., Giannaccinni, B., and Ordello, G. (1986). Evaluation of hyaluronic acid as a vehicle for topical ophthalmic drugs. Abstr. of Int. Symp. Ophthalmic Dosage Forms, Pisa, Oct. 13-14.
80. Saettone, M. F., Chetoni, P., and Giannaccinni, B. (1985). Evaluation of hyaluronic acid as a vehicle for topical ophthalmic drugs, Abstr. of 2nd Int. Conference on Polymers in Medicine, Capri, June 3-7.
81. Miyazaki, S., Ishii, K., and Takada, M. (1982). Use of fibrin film as a carrier for drug delivery: A long acting delivery system for pilocarpine into the eye. Chem. Pharm. Bull., 30: 3405.
82. Bloomfield, S. E., Miyata, T., Dunn, M. W., Bueser, N., Stenzel, K. H., and Rubin, A. L. (1978). Soluble gentamicin ophthalmic inserts as a drug delivery system, Arch. Ophthalmol., 96: 885.
83. McCoy, J. P., Jr. (1986). Contemporary laboratory applications of lectins, Biotechnique., 4: 252.
84. Kilpatrick, D. C., Pusztai, A., Grant, G., Graham, G., and Ewen, S. W. B. (1985). Tomato lectins resist degradation in the mammalian alimentary canal and binds to intestinal villi without deleterious effects, FEBS Lett., 185: 299.
85. Hynes, R. O., and Yamada, K. M. (1982). Fibronectins: Multifunctional modular glycoproteins, J. Cell Biol., 95: 369.
86. Nishida, T., Ohashi, Y., Awanta, T., and Manabe, R. (1983). Fibronectin, new therapy for corneal trophic ulcer, Arch. Ophthalmol., 101: 1046.
87. Lemp, M. H., and Szymanski, E. S. (1975). Polymer adsorption at the ocular surface, Arch. Ophthalmol., 99: 134.
88. Lehr, C. M., Lee, Y. H., and Lee, V. H. L. (1994). Improved ocular penetration of gentamicin by mucoadhesive polymer polycarbophil in the pigmented rabbit, Invest. Ophthalmol. Vis. Sci., 35: 2809-2814.
89. Ticho, U., Blumenthal, M., Zonis, S., Gal, A., Blank, L., Mazor, Z. W. (1979). A clinical trial with Piloplex®—a new long-acting pilocarpine compound: Preliminary report, Ann. Ophthalmol., April: 555.
90. Urtti, A., Salminen, L., Kujari, H., and Jantti, V. (1984). Effect of ocular pigmentation on pilocarpine pharmacology in the rabbit eye. II. Drug response, Int. J. Pharm., 19: 53.
91. Refojo, M. F. (1982). Current status of biomaterials in ophthalmology, Surv. Ophthalmol., 26: 257.
92. Refojo, M. F., Dohlman, C. H., and Koliopoulos, J. (1971). Adhesives in ophthalmology: A review, Surv. Ophthalmol., 15: 217.