Silicone rubber/hydrogel composite ophthalmic inserts: Preparation and preliminary in vitro/in vivo evaluation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 46, Issue 1, 1998, Pages 125-132

  Chetoni, Patrizia ^a   Di Colo, Giacomo ^a   Grandi, Massimo ^a   Morelli, Marco ^a   Saettone, M Fabrizio ^a   Darougar, Sohrab ^b  

^a UNIVERSITY OF PISA   (Italy)

^b IO International Limited   (United Kingdom)

Author keywords

In vitro mucoadhesion; In vitro in vivo drug release; Mucoadhesive ocular inserts; Ocular inserts; Ocular retention; Oxytetracycline; Polyacrylic acid; Polymethacrylic acid; Rabbit studies; Silicone

Indexed keywords

OXYTETRACYCLINE; POLYACRYLIC ACID; POLYMETHACRYLIC ACID; SILASTIC; SILASTIC MDX 44210; SILICONE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADHESION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; EYE INFECTION; HYDRATION; HYDROGEL; LACRIMAL FLUID; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; RABBIT; TOPICAL DRUG ADMINISTRATION;

ANIMALS; ANTI-BACTERIAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; EYE; HYDROGEL; MALE; MUCINS; OXYTETRACYCLINE; RABBITS; SILICONE ELASTOMERS;

EID: 0032442111     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(97)00168-9     Document Type: Article

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