Alteration in methylation pattern of oncogene akt1 promoter region in bladder cancer

Molecular Biology Reports

Volumn 39, Issue 5, 2012, Pages 5631-5636

  Sun, Xiao Feng ^a   Sun, Zhong Yi ^b   Pan, Bo ^a   Li, Lan ^a   Shen, Wei ^a  

^a QINGDAO AGRICULTURAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

AKT1; Bladder cancer; Methylation

Indexed keywords

BIOLOGICAL MARKER; BISULFITE; GENOMIC DNA; PROTEIN KINASE B;

ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER DIAGNOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EARLY DIAGNOSIS; GENETIC ANALYSIS; GENETIC MARKER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; METHYLATION; MOLECULAR CLONING; ONCOGENE; POLYMERASE CHAIN REACTION; PROMOTER REGION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; V AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOGUE 1; BLADDER; BLADDER TUMOR; CPG ISLAND; DNA SEQUENCE; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY;

BASE SEQUENCE; CPG ISLANDS; DNA METHYLATION; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; SEQUENCE ANALYSIS, DNA; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 84863767899     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1369-y     Document Type: Article

References (20)

1. Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2(7):489-501
2. Ermoian RP, Furniss CS, Lamborn KR et al (2002) Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin Cancer Res 8:1100-1106
3. Ruggeri BA, Huang L, Wood M et al (1998) Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog 21:81-86
4. Malik SN, Brattain M, Ghosh PM et al (2002) Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. Clin Cancer Res 8:1168-1171
5. Carpten JD, Faber AL, Horn C et al (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448(7152):439-444
6. Do H, Solomon B, Mitchell PL et al (2008) Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting. BMC Res Notes 1:14
7. Askham JM, Platt F, Chambers PA et al (2010) AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K. Oncogene 29(1):150-155
8. Chung JY, Hong SM, Choi BY et al (2009) The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma. Clin Cancer Res 15(2):660-667
9. Chang X, Ravi R, Pham V et al (2011) Adenylate kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplati n resistance. PLoS One 6(6):e20806
10. Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349(21):2042-2054
11. Pan B, Chao H, Chen B et al (2011) DNA methylation of germ cell-specific basic helix-loop-helix (HLH) transcription factors, Sohlh2 and Figlα during gametogenesis. Mol Hum Reprod 17(9):550-561
12. Bird AP (1986) CpG-rich islands and the function of DNA methylation. Nature 321:209-213
13. Adrien LR, Schlecht NF, Kawachi N et al (2006) Classification of DNA methylation patterns in tumor cell genomes using a CpG island microarray. Cytogenet Genome Res 114:16-23
14. Sato N, Goggins M (2006) Epigenetic alterations in intraductal papillary mucinous neoplasms of the pancreas. J Hepatobiliary Pancreat Surg 13:280-285
15. Torng PL, Lin CW, Chan MW et al (2009) Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma. Mol Cancer 8:120
16. Watts GS, Futscher BW, Holtan N et al (2008) DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage. BMC Med Genomics 1:47
17. Aleman A, Adrien L, Lopez-Serra L et al (2008) Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays. Br J Cancer 98(2):466-473
18. Du P, Ye HR, Gao J et al (2009) Methylation of PTCH1a gene in a subset of gastric cancers. World J Gastroenterol 15(30):3799-3806
19. Gao J, Song J, Huang H et al (2010) Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer. J Exp Clin Cancer Res 29:28
20. Shargh SA, Sakizli M, Farajnia S et al (2011) Evaluation of methylation pattern in promoter region of E-cadherin gene and its relation to tumor grade and stage in breast cancer. Afr J Biotechnol 10(10):1745-1751