Hypoxic hepatitis occurring in cirrhosis after variceal bleeding: Still a lethal disease

Journal of Clinical Gastroenterology

Volumn 46, Issue 7, 2012, Pages 608-612

  Amitrano, Lucio ^a   Guardascione, Maria Anna ^a   Martino, Rossana ^a   Manguso, Francesco ^a   Menchise, Antonella ^a   Balzano, Antonio ^a  

^a CARDARELLI HOSPITAL   (Italy)

Author keywords

bleeding; cirrhosis; hepatitis; hypoxic

Indexed keywords

ALANINE AMINOTRANSFERASE; CEPHALOSPORIN; SOMATOSTATIN;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIBIOTIC THERAPY; ARTICLE; CAUSE OF DEATH; CLINICAL FEATURE; CLINICAL PROTOCOL; DISEASE SEVERITY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEPATITIS; HUMAN; HYPOVOLEMIC SHOCK; HYPOXIC HEPATITIS; INTENSIVE CARE; KIDNEY FAILURE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION TEST; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; RISK FACTOR; SCLEROTHERAPY; STOMACH VARICES BLEEDING; SURGICAL TECHNIQUE; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; ESOPHAGEAL AND GASTRIC VARICES; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEPATITIS; HUMANS; INCIDENCE; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; RISK FACTORS;

EID: 84863746232     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e318254e9d4     Document Type: Article

References (34)

1. Gitlin N, Serio KM. Hypoxic hepatitis: Widening horizons. Am J Gastroenterol. 1992;87:831-836.
2. Seeto RK, Fenn B, Rockey DC. Ischemic hepatitis: Clinical presentation and pathogenesis. Am J Med. 2000;109:109-113.
3. Henrion J, Minette P, Colin L, et al. Hypoxic hepatitis caused by acute exacerbation of chronic respiratory failure: A casecontrolled, hemodynamic study of 17 cases. Hepatology. 1999;29:427-433.
4. Henrion J, Schapira M, Luwaert R, et al. Hypoxic hepatitis. Clinical and hemodynamic study in 142 consecutive cases. Medicine (Baltimore). 2003;82:392-406.
5. Fuchs S, Bogomolski-Yahalom V, Paltiel O, et al. Ischemic hepatitis: Clinical and laboratory observations in 34 patients. J Clin Gastroenterol. 1998;26:183-186.
6. Henrion J, Colin L, Schmitz A, et al. Ischemic hepatitis in cirrhosis: Rare but lethal. J Clin Gastroenterol. 1993;16:35-39.
7. Kamiyama T, Miyakawa H, Tajiri K, et al. Ischemic hepatitis in cirrhosis. Clinical features and prognostic implications. J Clin Gastroenterol. 1996;22:126-130.
8. Pauwels A, Levy VG. Ischemic hepatitis in cirrhosis: Not so rare, not always lethal. J Clin Gastroenterol. 1993;17:88-89.
9. Carbonell L, Pauwels A, Serfaty L, et al. Improved survival after variceal bleeding in patients with cirrhosis over the past two decades. Hepatology. 2004;40:652-659.
10. Stokkeland K, Brandt L, Ekbom A, et al. Improved prognosis for patients hospitalized with esophageal varices in Sweden 1969-2002. Hepatology. 2006;43:500-505.
11. de Franchis R. Updating consensus in portal hypertension. Report of the Baveno III Consensus Workshop on definitions, methodology and therapeutic strategies in portal hypertension. J Hepatol. 2000;33:846-852.
12. de Franchis R, Baveno V. Revising consensus in portal hypertension: Report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53:762-768.
13. Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the esophagus for bleeding oesophageal varices. Br J Surg. 1973;60:646-649.
14. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end stage liver disease. Hepatology. 2001;33:464-470.
15. Amitrano L, Guardascione MA, Menchise A, et al. Management of variceal hemorrhage in cirrhosis: The relevance of the risk stratification. Gut. 2011;60:1302-1303.
16. Jalan R, Williams R. Acute-on-chronic liver failure: Pathophysiological basis of therapeutic options. Blood Purif. 2002; 20:252-261.
17. Bosch J, Berzigotti A, Garcia-Pagan JC, et al. The management of portal hypertension: Rational basis, available treatments and future options. J Hepatol. 2008;48(suppl 1):S68-S92.
18. Mihas AA, Sanyal AJ. Recurrent variceal bleeding despite endoscopic and medical treatment. Gastroenterology. 2004;127: 621-629.
19. Bernard B, Cadranel JF, Valla S, et al. Prognostic significance of bacterial infection in bleeding cirrhotic patients: A prospective study. Gastroenterology. 1995;108:1828-1834.
20. Bernard B, Grange JD, Khac EN, et al. Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: A meta-analysis. Hepatology. 1999;29:1655-1661.
21. Ring A, Stremmel W. The hepatic microvascular responses to sepsis. Semin Thromb Hemost. 2000;26:589-594.
22. American College of Chest Physicians (Society of Critical Care Medicine Consensus Conference). Definition of sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864-874.
23. Garcia Pagan JC, Caca K, Bureau C, et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med. 2010;362:2370-2379.
24. Ebert EC. Hypoxic liver injury. Mayo Clin Proc. 2006;81: 1232-1236.
25. Iwakiri Y, Grisham M, Shah V. Vascular biology and pathobiology of the liver: Report of a single topic symposium. Hepatology. 2008;47:1754-1763.
26. Lautt WW. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: Hepatic arterial buffer response. Am J Gastrointest Liver Physiol. 1985;249:G549-G556.
27. Richter S, Mucke I, Menger MD, et al. Impact of intrinsic blood flow regulation in cirrhosis: Maintenance of hepatic arterial buffer response. Am J Physiol Gastrointest Liver Physiol. 2000;279:G454-G462.
28. Kleber G, Steudel N, Behrmann C, et al. Hepatic arterial flow volume and reserve in patients with cirrhosis: Use of intraarterial Doppler and adenosine infusion. Gastroenterology. 1999;116:906-914.
29. D'Amico G, De Franchis R, Cooperative Study Group. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology. 2003;38:599-612.
30. Sacerdoti D, Merkel C, Bolognesi M, et al. Hepatic arterial resistance in cirrhosis with and without portal vein thrombosis: Relationships with portal hemodynamics. Gastroenterology. 1995;108:1152-1158.
31. Orasanu G, Plutzky J. The continuum of diabetic vascular disease: from macro- to micro-J. Am Coll Cardiol. 2009; 53(suppl 5):S35-S42.
32. Rizzoni D, Rosei EA. Small artery remodeling in diabetes mellitus. Nutr Metab Cardiovasc Dis. 2009;19:587-592.
33. Wiernsperger NF. In defense of microvascular constriction in diabetes. Clin Hemorheol Microcirc. 2001;25:55-62.
34. Rijzewijk LJ, van der Meer RW, Lubberink M, et al. Liver fat content in type 2 diabetes: Relationship with hepatic perfusion and substrate metabolism. Diabetes. 2010;59:2747-2754.