Caspase-1 is active since the early phase of rheumatoid arthritis

Clinical and Experimental Rheumatology

Volumn 30, Issue 1, 2012, Pages 144-

  Cascao R ^a   Polido Pereira, J ^a,b   Canhao H ^a,b   Rodrigues, A M ^a,b   Navalho, M ^a,c   Raquel, H ^a   Neves Costa, A ^a   Mourao A F ^a,d   Resende, C ^b   Da Silva, J A P ^b   Fonseca, J E ^a,b   Moita, L F ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b HOSPITAL DE SANTA MARIA   (Portugal)

^c HOSPITAL DA LUZ   (Portugal)

^d HOSPITAL EGAS MONIZ   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; METHOTREXATE; PREDNISOLONE; RHEUMATOID FACTOR;

BLOOD SAMPLING; CELL POPULATION; DISEASE ASSOCIATION; DISEASE DURATION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; IMMUNE RESPONSE; LETTER; LOW DRUG DOSE; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADULT; ARTHRITIS, RHEUMATOID; CASPASE 1; DISEASE PROGRESSION; FEMALE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED;

EID: 84863730477     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Letter

References (10)

1. CASCAO R, MOURA RA, PERPETUO I et al. Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis. Arthritis Res Ther 2010; 12: R196.
2. PENE J, CHEVALIER S, PREISSER L et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008; 180: 7423-30.
3. AUPPERLE K, BENNETT B, HAN Z et al. NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes. J Immunol 2001; 166: 2705-11.
4. SIDIROPOULOS PI, GOULIELMOS G, VOLOUDAKIS GK, PETRAKI E, BOUMPAS DT. Inflammasomes and rheumatic diseases: evolving concepts. Ann Rheum Dis 2008; 67: 1382-9.
5. HOFFMAN HM, MUELLER JL, BROIDE DH, WANDERER AA, KOLODNER RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 2001; 29: 301-5.
6. DOWDS TA, MASUMOTO J, ZHU L, INOHARA N, NUNEZ G. Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 2004; 279: 21924-8.
7. KASTBOM A, VERMA D, ERIKSSON P et al. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). Rheumatology (Oxford) 2008; 47: 415-7.
8. KASTBOM A, JOHANSSON M, VERMA D, SODERKVIST P, RANTAPAA-DAHLQVIST S. CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis. Ann Rheum Dis 2010; 69: 723-6.
9. WEINMANN P, MOURA RA, CAETANO-LOPES JR et al. Delayed neutrophil apoptosis in very early rheumatoid arthritis patients is abrogated by methotrexate therapy. Clin Exp Rheumatol 2007; 25: 885-7.
10. MOURA RA, WEINMANN P, PEREIRA PA et al. Alterations on peripheral blood B-cell subpopulations in very early arthritis patients. Rheumatology (Oxford) 2010; 49: 1082-92.