Effect of nifedipine on anorectal sensorimotor functions in healthand fecal incontinence

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 1, 2011, Pages 1522-1547

  Bharucha, Adil E ^a   Edge, Jessica ^a   Zinsmeister, Alan R ^a  

^a MAYO CLINIC   (United States)

Author keywords

Calcium channel blockers; Pressure; Rectal capacity; Rectal compliance; Sensation

Indexed keywords

CALCIUM CHANNEL L TYPE; NIFEDIPINE; PLACEBO; CALCIUM CHANNEL BLOCKING AGENT; AMITRIPTYLINE; CITALOPRAM; ESCITALOPRAM; FLUOXETINE; SERTRALINE;

ADULT; ANORECTAL PRESSURE; ANUS SPHINCTER; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; FECES INCONTINENCE; FEMALE; HEART RATE; HUMAN; MUSCLE CONTRACTION; MUSCLE STIFFNESS; PRIORITY JOURNAL; SENSATION; SENSORIMOTOR FUNCTION; ANAL CANAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; INNERVATION; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RECTUM; SENSORY FEEDBACK; TREATMENT OUTCOME; BLOOD PRESSURE REGULATION; DIGESTIVE TRACT PARAMETERS; INTESTINE CONTRACTION; OSCILLATION; RECTUM DISTENSIBILITY; RIGIDITY;

ADULT; ANAL CANAL; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; FECAL INCONTINENCE; FEEDBACK, SENSORY; FEMALE; HEART RATE; HUMANS; MIDDLE AGED; NIFEDIPINE; RECTUM; TREATMENT OUTCOME;

EID: 84863730464     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00557.2010     Document Type: Article

References (34)

1. Andrews C, Bharucha AE, Camilleri M, Low PA, Seide B, Burton D, Baxter K, Zinsmeister AR. Rectal sensorimotor dysfunction in womenwith fecal incontinence. Am J Physiol Gastrointest Liver Physiol 292:G282-G289, 2007.
2. Bassotti G, Calcara C, Annese V, Fiorella S, Roselli P, Morelli A. Nifedipine and verapamil inhibit the sigmoid colon myoelectric responseto eating in healthy volunteers. Dis Colon Rectum 41: 377-380, 1998.
3. Bharucha AE, Dhamija S, Japp A, Seide B, Walters B, Stroetz R, Zinsmeister A, Hubmayr R. Contractile response to colonic distention isinfluenced by oscillation frequency. Neurogastroenterol Motil 17: 64-75,2005.
4. Bharucha AE, Fletcher JG, Harper CM, Hough D, Daube JR, Stevens C, Seide B, Riederer SJ, Zinsmeister AR. Relationship between symptomsand disordered continence mechanisms in women with idiopathicfecal incontinence. Gut 54: 546-555, 2005.
5. Bharucha AE, Locke GR, Seide B, Zinsmeister AR. A new questionnairefor constipation and fecal incontinence. Alimen Pharmacol Therapeut20: 355-364, 2004.
6. Bharucha AE, Seide B, Fox JC, Zinsmeister AR. Day-to-day reproducibilityof anorectal sensorimotor assessments in healthy subjects. NeurogastroenterolMotil 16: 241-250, 2004.
7. Bharucha AE, Seide BM, Zinsmeister AR. The effects of clonidine onsymptoms and anorectal sensorimotor function in women with faecalincontinence. Alimentary Pharmacol Therapeut 32: 681-688, 2010.
8. Bharucha AE, Zinsmeister AR, Locke GR, Schleck C, McKeon K, Melton LJ. Symptoms and quality of life in community women with fecalincontinence. Clin Gastroenterol Hepatol 4: 1004-1009, 2006.
9. Bharucha AE, Zinsmeister AR, Locke GR, Seide B, McKeon K, Schleck CD, Melton LJI. Prevalence and burden of fecal incontinence: apopulation based study in women. Gastroenterology 129: 42-49, 2005.
10. Brisinda G, Maria G. Oral nifedipine reduces resting anal pressure andheals chronic anal fissure (Abstract). Br J Surg 87: 251, 2000.
11. Chakder S, Sarma DN, Rattan S. Mechanism of internal anal sphinctersmooth muscle relaxation by phorbol 12,13-dibutyrate. Am J PhysiolGastrointest Liver Physiol 280: G1341-G1350, 2001.
12. Deutekom M, Dobben AC, Terra MP, Engel AF, Stoker J, Bossuyt PM, Boeckxstaens GE. Clinical presentation of fecal incontinence andanorectal function: what is the relationship? Am J Gastroenterol 102:351-361, 2007.
13. Farrugia G, Holm AN, Rich A, Sarr MG, Szurszewski JH, Rae JL. Amechanosensitive calcium channel in human intestinal smooth musclecells. Gastroenterology 117: 900-905, 1999.
14. Fox JC, Fletcher JG, Zinsmeister AR, Seide B, Riederer SJ, Bharucha AE. Effect of aging on anorectal and pelvic floor functions in females[erratum appears in Dis Colon Rectum 50: 404, 2007]. Dis Colon Rectum49: 1726-1735, 2006.
15. Fredberg JJ, Inouye D, Miller B, Nathan M, Jafari S, Raboudi SH, Butler JP, Shore SA. Airway smooth muscle, tidal stretches, and dynamicallydetermined contractile states. Am J Respir Crit Care Med 156: 1752-1759, 1997.
16. Holm AN, Rich A, Sarr MG, Farrugia G. Whole cell current andmembrane potential regulation by a human smooth muscle mechanosensitivecalcium channel. Am J Physiol Gastrointest Liver Physiol 279:G1155-G1161, 2000.
17. Hongo M, Traube M, McAllister RG Jr, McCallum RW. Effects ofnifedipine on esophageal motor function in humans: correlation withplasma nifedipine concentration. Gastroenterology 86: 8-12, 1984.
18. Kelly JG, O'Malley K. Clinical pharmacokinetics of calcium antagonists.An update. Clin Pharmacokinet 22: 416-433, 1992.
19. Kraichely RE, Farrugia G. Mechanosensitive ion channels in interstitialcells of Cajal and smooth muscle of the gastrointestinal tract. NeurogastroenterolMotil 19: 245-252, 2007.
20. Law NM, Bharucha AE, Undale AS, Zinsmeister AR. Cholinergicstimulation enhances colonic motor activity, transit, and sensation in humans. Am J Physiol Gastrointest Liver Physiol 281: G1228-G1237, 2001.
21. Mutafova-Yambolieva VN, O'Driscoll K, Farrelly A, Ward SM, Keef KD. Spatial localization and properties of pacemaker potentials in thecanine rectoanal region. Am J Physiol Gastrointest Liver Physiol 284:G748-G755, 2003.
22. Naliboff BD, Berman S, Suyenobu B, Labus JS, Chang L, Stains J, Mandelkern MA, Mayer EA. Longitudinal change in perceptual andbrain activation response to visceral stimuli in irritable bowel syndromepatients. Gastroenterology 131: 352-365, 2006.
23. Narducci F, Bassotti G, Gaburri M, Farroni F, Morelli A. Nifedipinereduces the colonic motor response to eating in patients with the irritablecolon syndrome. Am J Gastroenterol 80: 317-319, 1985.
24. Richter JE, Dalton CB, Buice RG, Castell DO. Nifedipine: a potentinhibitor of contractions in the body of the human esophagus. Studies inhealthy volunteers and patients with the nutcracker esophagus. Gastroenterology89: 549-554, 1985.
25. Santander R, Mena I, Gramisu M, Valenzuela JE. Effect of nifedipineon gastric emptying and gastrointestinal motility in man. Dig Dis Sci 33:535-539, 1988.
26. Santoro GA, Eitan BZ, Pryde A, Bartolo DC. Open study of low-doseamitriptyline in the treatment of patients with idiopathic fecal incontinence. Dis Colon Rectum 43: 1676-1681, 2000.
27. Sasaki H, Hoppin FG Jr. Hysteresis of contracted airway smooth muscle. J Appl Physiol 47: 1251-1262, 1979.
28. Shen X, Gunst SJ, Tepper RS. Effect of tidal volume and frequency onairway responsiveness in mechanically ventilated rabbits. J Appl Physiol83: 1202-1208, 1997.
29. Siproudhis L, El Abkari M, El Alaoui M, Juguet F, Bretagne JF. Lowrectal volumes in patients suffering from fecal incontinence: what does itmean? Alimentary Pharmacol Therapeut 22: 989-996, 2005.
30. Smout AJ, Devore MS, Dalton CB, Castell DO. Effects of nifedipine onesophageal tone and perception of esophageal distension. Dig Dis Sci 37:598-602, 1992.
31. Sorkin EM, Clissold SP, Brogden RN. Nifedipine. A review of itspharmacodynamic and pharmacokinetic properties, and therapeutic efficacy,in ischaemic heart disease, hypertension and related cardiovasculardisorders. Drugs 30: 182-274, 1985.
32. Tack J, Broekaert D, Corsetti M, Fischler B, Janssens J. Influence ofacute serotonin reuptake inhibition on colonic sensorimotor function inman. Alimentary Pharmacol Therapeut 23: 265-274, 2006.
33. Traube M, Lange RC, McAllister RG Jr, McCallum RW. Effect ofnifedipine on gastric emptying in normal subjects. Dig Dis Sci 30:710-712, 1985.
34. Viramontes BE, Malcolm A, Camilleri M, Szarka LA, McKinzie S, Burton DD, Zinsmeister AR. Effects of an alpha(2)-adrenergic agoniston gastrointestinal transit, colonic motility, and sensation in humans. AmJ Physiol Gastrointest Liver Physiol 281: G1468-G1476, 2001.