Hormonal determinants and effect of ER22/23EK glucocorticoid receptor gene polymorphism on health status deterioration in the participants of the Mataró Ageing Study

Age

Volumn 34, Issue 3, 2012, Pages 553-561

  Mora, Mireia ^a   Sánchez, Lidia ^a   Serra Prat, Mateu ^b   Palomera, Elisabet ^b   Blanco, Jesús ^a   Aranda, Gloria ^a   Falcón, Immaculada ^c   Cadenas, Immaculada ^d   Boquet, Xavier ^e   Oriola, Josep ^a   Puig Domingo, Manuel ^f  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Research Unit   (Spain)

^c ABS Cirera Molins   (Spain)

^d ABS Argentona   (Spain)

^e HOSPITAL DE MATARÓ   (Spain)

^f UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Ageing; Cognitive function; Depression; Frailty; Functional capacity; Nutritional status; Steroidal hormones

Indexed keywords

CORTICOSTEROID; ESTRADIOL; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; PRASTERONE; PRASTERONE SULFATE; SEX HORMONE; SOMATOMEDIN C RECEPTOR; TESTOSTERONE;

AGE; AGED; ANDROGEN BLOOD LEVEL; ARTICLE; BARTHEL INDEX; CARDIOMETABOLIC RISK; CONTROLLED STUDY; DEPRESSION; EDUCATIONAL STATUS; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLOW UP; FUNCTIONAL STATUS; GC R GENE; GENDER; GENE; GENETIC POLYMORPHISM; GERIATRIC DEPRESSION SCALE; HORMONE DETERMINATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERTENSION; MALE; MENTAL HEALTH; MINI MENTAL STATE EXAMINATION; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PHYSICAL EXAMINATION; POPULATION RESEARCH; PROSPECTIVE STUDY; SPAIN; TESTOSTERONE BLOOD LEVEL; WEIGHT REDUCTION;

AGED; AGING; COGNITION; DEPRESSION; DNA; FEMALE; FOLLOW-UP STUDIES; FRAIL ELDERLY; HEALTH STATUS; HUMANS; MALE; METABOLIC SYNDROME X; MOTOR ACTIVITY; PHENOTYPE; POLYMORPHISM, GENETIC; PREVALENCE; PROSPECTIVE STUDIES; RECEPTORS, GLUCOCORTICOID; RISK FACTORS; SPAIN; TIME FACTORS;

EID: 84863728719     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9255-z     Document Type: Article

References (33)

1. Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 23:469-480
2. Aleman A, Verhaar HJ, de Haan EH, de Vries WR, Samson MM, Drent ML, van der Veen EA, Koppeschaar HP (1999) Insulin-like growth factor-I and cognitive function in healthy older men. J Clin Endocrinol Metab 84:471-475 (Pubitemid 29075671)
3. Barrett-Connor E, Von Mühlen DG, Kritz-Silverstein D (1999a) Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo Study. J Clin Endocrinol Metab 84:573-577 (Pubitemid 29075686)
4. Barrett-Connor E, von Muhlen D, Laughlin GA, Kripke A (1999b) Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo Study. J Am Geriatr Soc 47:685-691 (Pubitemid 29266635)
5. Barrett-Connor E, von Mühlen DG, Kritz-Silverstein D (1999c) Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo Study. J Clin Endocrinol Metab 84:2573-2577
6. Bologa L, Sharma J, Roberts E (1987) Dehydroepiandrosterone, and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures. J Neurosci Res 17:225-234 (Pubitemid 17074671)
7. Brill KT, Weltman AL, Gentili A, Patrie JT, Fryburg DA, Hanks JB, Urban RJ, Veldhuis JD (2002) Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. J Clin Endocrinol Metab 87:5649-5657 (Pubitemid 36034373)
8. Cappola AR, Bandeen-Roche K, Wand GS, Volpato S, Fried LP (2001) Association of IGF-I levels with muscle strength and mobility in older women. J Clin Endocrinol Metab 86:4139-4146 (Pubitemid 32848526)
9. De Bruin VM, Vieira MC, Rocha MN, Viana GS (2002) Cortisol and dehydroepiandrosterone sulfate plasma levels and their relationship to aging, cognitive function and dementia. Brain Cogn 50:316-323 (Pubitemid 36034611)
10. Folstein MF, Folstein SE, McHugh PR (1975) Mini Mental State: a practical method for grading the cognitive state patients for the clinician. J Psychiatr Res 12:189-198
11. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, GottdienerJ ST, Tracy R, Kop WJ, Burke G, McBurnie MA, Cardiovascular Health Study Collaborative Research G (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146-M156 (Pubitemid 32187141)
12. Gurnell EM, Chatterjee VK (2001) Dehydroepiandrosterone replacement therapy. Eur J Endocrinol 145:103-106 (Pubitemid 32707595)
13. Hoyl MT, Alessi CA, Harker JO, Josephson KR, Pietruszka FM, Koelfgen M, Mervis JR, Fitten LJ, Rubinstein LZ (1999) Development and testing of a five-item version of the Geriatric Depression Scale. J Am Geriatr Soc 47(7):873-878 (Pubitemid 29326021)
14. Hunt PJ, Gurnell EM, Huppert FA, Richards C, Prevost AT, Wass JA, Herbert J, Chatterjee VK (2000) Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomised, double blind trial. J Clin Endocrinol Metab 85:4650-4656 (Pubitemid 32157648)
15. Janssen JA, Stolk RP, Pols HA, Grobbe DE, de Jong FH, Lamberts SW (1998) Serum free IGF-I, total IGF-I, IGFBP-1 and IGFBP-3 levels in an elderly population: relation to age and sex steroids levels. Clin Endocrinol 48:471-478 (Pubitemid 28258820)
16. Kalminj S, Launer LJ, Stolk RP, de Jong FH, Pols HA, Hofman A, Breteler MM, Lamberts SW (1998) A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly. J Clin Endocrinol Metab 83:3487-3492 (Pubitemid 28500876)
17. Lamberts SWJ, van den Beld AW, van der Lely AJ (1997) The endocrinology of aging. Science 278:419-424 (Pubitemid 27454418)
18. Lawton MP, Brody E (1969) Assessment of older people: selfmaintaining and instrumental activities of daily living. Gerontologist 9:179-186
19. Lupien SJ, Gaudreau S, Tchiteya BM, Maheu F, Sharma S, Nair NP, Hauger RL, McEwen BS, Meaney MJ (1997) Stressinduced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity. J Clin Endocrinol Metab 82:2070-2075 (Pubitemid 27287563)
20. Mahoney FI, Barthel DW (1965) Functional evaluation: The Barthel Index. Md State Med J 14:61-65
21. Mohr BA, Guay AT, O'Donnell AB, McKinley JB (2005) Normal, bound and nonbound testosterone levels in normally ageing men: results from the Massachussets Male Ageing Study. Clin Endocrinol 62:64-73 (Pubitemid 40175285)
22. Nair KS, Rizza RA, O'Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ 3rd, Smith GE, Khosla S, Jensen MD (2006) DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 355:1647-1659 (Pubitemid 44583955)
23. Nieschlag E, Swerldloff R, Berhe HM, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morley JE, Schulman C, Wang C, Weidner W, Wu FC (2005) Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. J Androl 28:125-127 (Pubitemid 40780337)
24. Puig-Domingo M, Serra-Prat M, Merino MJ, Pubill M, Burdoy E, Papiol M (2008) Muscle strength in the Mataró aging study participants ans its relationxhip to successful aging. Aging Clin Exp Res 20(5):439-446
25. Rubenstein LZ, Harker JO, Salva A, Guigoz Y, Vellas B (2001) Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNASF). J Gerontol A Biol Sci Med Sci 56(6):M366-M372 (Pubitemid 32522256)
26. Sapolky RM, Uno H, Rebert CS, Finch CE (1990) Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci 10:2897-2902
27. Seeman TE, McEwen BS, Singer BH, Albert MS, Rowe JW (1994) Increase in urinary cortisol excretion and memory declines: McArthur studies on successful aging. J Neurisc 14:2893-2903
28. Tenofer JC (1992) Effects of testosterone suplementation in the aging male. J Clin Endocrinol Metab 75:1092-1098
29. Van Rossum EF, Lamberts SW (2004) Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res 59:333-357
30. Van Rossum EF, Feelders RA, Van den Beld AW, Uitterlinden AG, Janssen JA, Ester W, Brinkmann AO, Grobbee DE, de Jong FH, Pols HA, Koper JW, Lamberts SW (2004) Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. Am J Med 117:158-162 (Pubitemid 39055866)
31. Van Rossum EF, Russcher H, Lamberts SW (2005) Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor gene. Trends Endocrinol Metab 16:445-450 (Pubitemid 41660860)
32. Wang C, Eyre DR, Clark R, Kleinberg D, Newman C, Iranmanesh A, Veldhuis J, Dudley RE, Berman N, Davidson T, Barstow TJ, Sinow R, Alexander G, Swerdloff RS (1996) Sublingual testosterone replacement improves musclemass and strength, decreases bone resorption and increases bone formation markers in hypogonadal men. J Clin Endocrinol Metab 80:3654-3662 (Pubitemid 26339933)
33. Wolf OT (2003) Cognitive functions and sex steroids. Ann Endocrinol 64:158-161 (Pubitemid 36565176)