Selective apoptosis in hepatic stellate cells mediates the antifibrotic effect of phenanthrenes from Dendrobium nobile

Phytotherapy Research

Volumn 26, Issue 7, 2012, Pages 974-980

  Yang, Hyekyung ^a   Lee, Phil Jun ^b   Jeong, Eun Ju ^a   Kim, Hong Pyo ^c   Kim, Young Choong ^a  

^a Seoul National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c University of Ulsan   (South Korea)

Author keywords

antifibrotic activity; autophagy apoptosis; Dendrobium nobile; hepatic fibrosis; hepatic stellate cell; phenanthrenes

Indexed keywords

2,3,5 TRIHYDROXY 4,9 DIMETHOXYPHENANTHRENE; DENBINOBIN; EPIGALLOCATECHIN GALLATE; FIMBRIOL B; PHENANTHRENE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIFIBROTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CELL GROWTH; CELL LOSS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDROBIUM; DENDROBIUM NOBILE; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; GROWTH INHIBITION; LIVER CELL; NONHUMAN; PLANT STEM; STELLATE CELL;

ANIMALS; ANTHRAQUINONES; APOPTOSIS; AUTOPHAGY; CELL LINE; CELL SURVIVAL; COLLAGEN; DENDROBIUM; HEPATIC STELLATE CELLS; HEPATOCYTES; MACROPHAGES; MICE; PHENANTHRENES; PLANT EXTRACTS; RATS; TUMOR NECROSIS FACTOR-ALPHA;

DENDROBIUM NOBILE; RATTUS;

EID: 84863728610     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3632     Document Type: Article

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