Hepatocellular adenoma associated with long-term exposure to phenobarbital: A paediatric case report

Child's Nervous System

Volumn 28, Issue 6, 2012, Pages 939-941

  Cerminara, Caterina ^a   Bagnolo, Valentina ^a   De Leonardis, Francesco ^a   Coniglio, Antonella ^a   Roberto, Denis ^a   Compagnone, Eliana ^a   Curatolo, Paolo ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; PHENOBARBITAL;

ADOLESCENT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BILIRUBIN BLOOD LEVEL; BRAIN ARTERIOVENOUS MALFORMATION; CASE REPORT; CHRONIC DRUG ADMINISTRATION; ECHOGRAPHY; ELECTROENCEPHALOGRAPHY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; LABORATORY TEST; LIVER ADENOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RADIOSURGERY; SEIZURE; SIDE EFFECT; SYMPTOM;

ADENOMA, LIVER CELL; ADOLESCENT; ANTICONVULSANTS; EPILEPSY; FEMALE; HUMANS; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; LIVER NEOPLASMS; PHENOBARBITAL; RADIOSURGERY;

EID: 84863727575     PISSN: 02567040     EISSN: 14330350     Source Type: Journal    
DOI: 10.1007/s00381-011-1636-1     Document Type: Article

References (29)

1. de Buy M, Wenniger L, Terpstra V, Beuers U (2010) Focal nodular hyperplasia and hepatic adenoma: epidemiology and pathology. Dig Surg 27(1):24-31
2. Rooks JB, Ory HW, Ishak KG et al (1979) Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA 242(7):644-648 (Pubitemid 9252465)
3. Socas L, Zumbado M, Pérez-Luzardo O et al (2005) Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and a review of the literature. Br J Sports Med 39(5):27
4. Oshita A, Itamoto T, Amano H et al (2008) Perioperativemanagement of benign hepatic tumors in patients with glycogen storage disease type Ia. J Hepatobiliary Pancreat Surg 15(2):200-203 (Pubitemid 351516980)
5. Resnick MB, Kozakewich HP, Perez-Atayde AR (1995) Hepatic adenoma in the pediatric age group. Clinicopathological observations and assessment of cell proliferative activity. Am J Surg Pathol 19 (10):1181-1190
6. Levy RH, Mattson RH, Meldrum BS et al (2002) Antiepileptic drugs, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 528-540
7. Clemmesen J, Hjalgrim-Jensen S (1978) Is phenobarbital carcinogenic? A follow-up of 8078 epileptics. Ecotoxicol Environ Saf 1 (4):457-470 (Pubitemid 9030956)
8. Clemmesen J, Hjalgrim-Jensen S (1981) Does phenobarbital cause intracranial tumors? A follow-up through 35 years. Ecotoxicol Environ Saf 5(2):255-260 (Pubitemid 11088606)
9. White SJ, McLean AE, Howland C (1979) Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy. Lancet 2(8140):458-461
10. Olsen JH, Boice JD Jr, Jensen JP, Fraumeni JF Jr (1989) Cancer among epileptic patients exposed to anticonvulsant drugs. J Natl Cancer Inst 81(10):803-808 (Pubitemid 19137445)
11. Olsen J, Wallin H, Boice JD Jr et al (1993) Phenobarbital, drug metabolism, and human cancer. Cancer Epidemiol Biomarkers Prev 2(5):449-452
12. Lamminpää A, Pukkala E, Teppo L, Neuvonen PJ (2002) Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients. Eur J Clin Pharmacol 58(2):137-141
13. Peraino C, Fry RJ, Staffeldt E (1971) Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2- acetylaminofluorene. Cancer Res 31(10):1506-1512
14. Driver HE, McLean AE (1986) Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol. Food Chem Toxicol 24(3):241-245 (Pubitemid 16128944)
15. Diwan BA, Rice JM, Nims RWet al (1988) P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats. Cancer Res 48(9):2492-2497
16. Singh G, Driever PH, Sander JW (2005) Cancer risk in people with epilepsy: the role of antiepileptic drugs. Brain 128(Pt 1):7-17 (Pubitemid 40073649)
17. Lautz TB, Finegold MJ, Chin AC, Superina RA (2008) Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy. J Pediatr Surg 43(4):751-754 (Pubitemid 351474538)
18. Seki A, Inoue T, Maegaki Yet al (2006) Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman. No To Hattatsu 38(3):205-208 (Pubitemid 43761944)
19. Tazawa K, Yasuda M, Ohtani Yet al (1999) Multiple hepatocellular adenomas associated with long-term carbamazepine. Histopathology 35(1):92-94 (Pubitemid 29325307)
20. Rignall B, Braeuning A, Buchmann A, Schwarz M (2011) Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen. Carcinogenesis 32(1):52-57
21. Phillips JM, Goodman JI (2009) Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptormediated DNA methylation changes during liver tumorigenesis and in liver tumors. Toxicol Sci 108(2):273-289
22. Phillips JM, Burgoon LD, Goodman JI (2009) Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice. Toxicol Sci 109 (2):193-205
23. Klaunig JE (1993) Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital. Environ Health Perspect 101(Suppl 5):235-239 (Pubitemid 24096356)
24. Hyman GA, Sommers SC (1966) The development of Hodgkin's disease and lymphoma during anticonvulsant therapy. Blood 28 (3):416-427
25. Kruger GR, Harris D (1972) Is phenytoin carcinogenic? Lancet 1 (7745):323
26. Vázquez JJ, Marigil MA (1989) Liver-cell adenoma in an epileptic man on barbiturates. Histol Histopathol 4(3):301-303 (Pubitemid 19177947)
27. Ferko A, Bedrna J, Nozicka J (2003) Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital. Rozhl Chir 82(4):192-195
28. Warner KA, Fernstrom MJ, Ruch RJ (2003) Inhibition of mouse hepatocyte gap junctional intercellular communication by phenobarbital correlates with strain-specific hepatocarcinogenesis. Toxicol Sci 71(2):190-197 (Pubitemid 36285011)
29. Michelucci R (2006) Optimizing therapy of seizures in neurosurgery.Neurology 67(12 Suppl 4):S14-S18 (Pubitemid 44967991)