Stress response and procedural pain in the preterm newborn: The role of pharmacological and non-pharmacological treatments

European Journal of Pediatrics

Volumn 171, Issue 6, 2012, Pages 927-933

  Gitto, Eloisa ^a   Pellegrino, Salvatore ^a   Manfrida, Maria ^a   Aversa, Salvatore ^b   Trimarchi, Giuseppe ^a   Barberi, Ignazio ^a   Reiter, Russel J ^c  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Interleukins; Preterm; Procedural pain; Stress response

Indexed keywords

FENTANYL; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ANALGESIA; ARTICLE; CLINICAL EVALUATION; CONDITIONING; CONTROLLED STUDY; FACILITATED TUCKING; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; NEWBORN; PAIN; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; STRESS; TREATMENT OUTCOME;

ANALGESICS, OPIOID; BIOLOGICAL MARKERS; BLOOD SPECIMEN COLLECTION; FACILITATED TUCKING; FEMALE; FENTANYL; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INJECTIONS, INTRAVENOUS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; PAIN; PAIN MANAGEMENT; PAIN MEASUREMENT; PHYSICAL STIMULATION; PROSPECTIVE STUDIES; STRESS, PHYSIOLOGICAL; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863726991     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-011-1655-7     Document Type: Article

References (62)

1. Adams HA, Hempelmann G (1991) The endocrine stress reaction in anesthesia and surgery-origin and significance. Anasthesiol Intensivmed Notfallmed Schmerzther 26:294-305
2. Anand KJ, Aynsley-Green A (1985) Metabolic and endocrine effects of surgical ligation of patentductus arteriosus in the human preterm neonate: Are there implications for further improvement of postoperative outcome? Mod Probl Paediatr 23:143-147
3. Anand KJ, Hickey PR (1992) Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery. N Engl J Med 326:1-9
4. Anand KJ (1998) Clinical importance of pain and stress in preterm neonates. Biol Neonate 73:1-9
5. Anand KJS, McIntosh N, Lagercrantz H, Pelusa E, Young TE, Vasa R (1999) Analgesia and sedation in preterm neonates who require ventilatory support. Results from the NOPAIN trial. Arch Pediatr Adolesc Med 153:331-338
6. Anand KJ, Scalzo FM (2000) Can adverse neonatal experiences alter brain development and subsequent behaviour? Biol Neonate 77:69-82
7. Anand KJS, Hall RW, Desai N, Shephard B, Bergqvist L, Young TE, Boyle EM Carbajal R, Bhutani VK, Moore MB, Kronsberg SS, Barton BA, or the NEOPAIN Trial (2004) Effects of morphine analgesia in ventilated preterm neonates: Primary outcomes from the NEOPAIN randomised trial. Lancet 363:1673-1682
8. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli EV, Carlo W, Hummel P, Johnston CC, Lantos J, Tutag-Lehr V, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA (2006) Summary proceedings from the neonatal pain-control group. Pediatrics 117:S9-S22
9. Aretz S, Licht C, Roth B (2004) Endogenous distress in ventilated full-term newborns with acute respiratory failure. Biol Neonate 85:243-248
10. Arnold JH, Truog RD, Scavone JM, Fenton T (1991) Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion. J Pediatr 119:639-643
11. Bellieni CV, Buonocore G, Nenci A, Franci N, Cordelli DM, Bagnoli F (2001) Sensorial saturation: An effective analgesic tool for heel-prick in preterm infants: A prospective randomized trial. Biol Neonate 80:15-18
12. Bellieni CV, Bagnoli F, Perrone S, Nenci A, Cordelli DM, Fusi M, Ceccarelli S, Buonocore G (2002) Effect of multisensory stimulation on analgesia in term neonates: A randomised controlled trial. Pediatr Res 51:460-463
13. Bellieni CV, Bagnoli F, Buonocore G (2003) Alone no more: Pain in premature children. Ethics Med 19:5-9
14. Bellieni CV, Burroni A, Perrone S, Cordelli DM, Nenci A, Lunghi A, Buonocore G (2003) Intracranial pressure during procedural pain. Biol Neonate 84:202-205
15. Bellieni CV, Cordelli DM, Marchi S, Ceccarelli S, Perrone S, Maffei M, Buonocore G (2007) Sensorial saturation for neonatal analgesia. Clin J Pain 23:219-221
16. Bellù R, deWaal KA, Zanini R (2008) Opioids for neonates receiving mechanical ventilation. Cochrane Database of Systematic Reviews, Issue 1. Art. No: CD004212. doi:10.1002/14651858.CD004212.pub3
17. Buvanendran A, Kroin JS, Berger RA, Hallab NJ, Saha C, Negrescu C, Moric M, Caicedo MS, Tuman KJ (2006) Upregulation of prostaglandin E2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans. Anesthesiology 104:403-410
18. Carbajal R, Gall O, Annequin D (2004) Pain management in neonates. Expert Rev Neurother 4:491-505
19. Carvalho B, Clark DJ, AngstMS (2008) Local and systemic release of cytokines, nerve growth factor, prostaglandin E2, and substance P in incisional wounds and serum following cesarean delivery. J Pain 9:650-657
20. Chichorro JG, Lorenzetti BB, Zampronio AR (2004) Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats. Br J Pharmacol 141:1175-1184
21. Cignacco E, Hamers JP, Stoffel L, van Lingen RA, Gessler P, McDougall J, Nelle M (2007) The efficacy of non-pharmacological interventions in the management of procedural pain in preterm and term neonates. A systematic literature review. Eur J Pain 11:139-152
22. Corff K, Seideman R, Venkataraman S, Lutes L, Yates B (1995) Facilitated tucking: A nonpharmacologic comfort measure for pain in preterm neonates. J Obstet Gynecol Neonatal Nurs 24:143-147
23. Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH (1992) The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107:660-664
24. Czlonkowski A, Stein C, Herz A (1993) Peripheral mechanisms of opioid antinociception in inflammation: Involvement of cytokines. Eur J Pharmacol 242:229-235
25. De Jongh RF, Vissers KC, Meert TF, Booij LHDJ, De Deyne CS, Heylen RJ (2003) The role of interleukin-6 in nociception and pain. Anesth Analg 96:1096-1103
26. Dyke MP, Kohan R, Evans S (1995) Morphine increases synchronous ventilation in preterm infants. J Paediatr Child Health 31:176-179
27. Fitzgerald M, Millard C, MacIntosh N (1988) Hyperalgesia in premature infants. Lancet 1:292
28. Fitzgerald M, Millard C, McIntosh N (1989) Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia. Pain 39:31-36
29. Gillitzer R, Goebeler M (2001) Chemokines in cutaneous wound healing. J Leukoc Biol 69:513-521
30. Goldman RD, Koren G (2002) Biologic markers of pain in the vulnerable infant. Clin Perinatol 29:415-425
31. Goldstein RF, Brazy JE (1991) Narcotic sedation stabilizes arterial blood pressure fluctuations in sick premature infants. J Perinatol 11:365-371
32. Grunau R (2002) Early pain in preterm infants: A model of longterm effects. Clin Perinatol 29:373-394
33. Guinsburg R, Kopelman BI, Anand KJ, de Almeida MF, Peres Cde A, Miyoshi MH (1998) Physiological, hormonal, and behavioral responses to a single fentanyl dose in intubated and ventilated preterm neonates. J Pediatr 132:954-959
34. Hall RW, Boyle E, Young T (2007) Do ventilated neonates require pain management? Semin Perinatol 31:289-297
35. Huang CM, Tung WS, Kuo LL, Chang YJ (2004) Comparison of pain responses of premature infants to the heelstick between containment and swaddling. J Nurs Res 12:31-40
36. Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA (2001) IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14:705-714
37. Jones JE, Kassity N (2001) Varieties of alternative experience: Complementary care in the neonatal intensive care unit. Clin Obstet Gynecol 44:750-768
38. Kehlet H (1988) The modifying effect of anesthetic technique on the metabolic and endocrine responses to anesthesia and surgery. Acta Anaesthesiol Belg 39:143-146
39. Khadra A, Fletcher P, Luzzi G, Shattock R, Hay P (2006) Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and non-specific urethritis. BJU Int 97:1043-1046
40. Krechel SW, Bildner J (1995) CRIES: A new neonatal postoperative pain measurement score. Initial testing of validity and reliability. Paediatr Anaesth 5:53-61
41. Lago P, Benini F, Agosto C, Zacchello F (1998) Randomised controlled trial of low dose fentanyl infusion in preterm infants with hyaline membrane disease. Arch Dis Child Fetal Neonatal Ed 79:F194-F197
42. Menon G, Anand KJ, McIntosh N (1998) Practical approach to analgesia and sedation in the neonatal intensive care unit. Semin Perinatol 22:417-424
43. Orsini AJ, Leef KH, Costarino A, Dettore MD, Stefano JL (1996) Routine use of fentanyl infusions for pain and stress reduction in infants with respiratory distress syndrome. J Pediatr 129:140-145
44. Pokela ML (1994) Pain relief can reduce hypoxaemia in distressed neonates during routine treatment procedures. Pediatrics 93:379-383
45. Przewlocki R, Hassan AHS, Lason W, Epplen C, Herz A, Stein C (1992) Gene expression and localization of opioid peptides in immune cells of inflamed tissue: Functional role in antinociception. Neuroscience 48:491-500
46. QuinnMW,Wild J, Dean HG, Hartley R, Rushforth JA, Puntis JW, Levene MI (1993) Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies. Lancet 342:324-327
47. Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, Faggioni R, Luini W, van Hinsbergh V, Sozzani S, Bussolino F, Poli V, Ciliberto G, Mantovani A (1997) Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6:315-325
48. Saarenmaa E, Huttunen P, Leppäluoto J, Meretoja O, Fellman V (1999) Advantages of fentanyl over morphine in analgesia for ventilated newborn infants after birth: A randomized trial. J Pediatr 134:144-150
49. Simons SH, van Dijk M, van Lingen RA, Roofthooft D, Duivenwoorden HJ, Johgeneel N, Bunkers C, Smink E, Anand KJ, van der Aker, Tibboel D (2003) Routine morphine infusion in preterm newborns who received ventilatory support: A randomized controlled trial. JAMA 290:2419-2427
50. Steed DL (1997) The role of growth factors in wound healing. Surg Clin North Am 77:575-586
51. Stein C, Hassan AHS, Przewlocki R, Gramsch C, Peter K, Herz A (1990) Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc Natl Acad Sci USA 87:5935-5939
52. Stevens BJ, Johnston CC (1994) Physiological responses of premature infants to a painful stimulus. Nurs Res 43:226-231
53. Stevens B, Johnston C, Petryshen P, Taddio A (1996) Premature infant pain profile: Development and initial validation. Clin J Pain 12:13-22
54. Stevens B, Gibbins S, Sturla Franck L (2000) Treatment of pain in the neonatal intensive care unit. Pediatr Clin North Am 47:633-650
55. Suganuma MM (2002) Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation. Int J Oncol 20:131-136
56. Tsuji M, Saul P, du Plessis A, Eichenwald E, Sobh J, Crocker R, Volpe JJ (2000) Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics 106:625-632
57. Uçeyler N, Sommer C (2008) Cytokine regulation in animal models of neuropathic pain and in human diseases. Neurosci Lett 437:194-198
58. Yamada J, Stinson J, Lamba J, Dickson A, McGrath PJ, Stevens B (2008) A review of systematic reviews on pain interventions in hospitalized infants. Pain Res Manag 13:413-420
59. Wang XM, Hamza M, Wu TX, Dionne RA (2009) Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: Correlation to clinical pain. Pain 142:275-283
60. Ward-Larson C, Horn R, Gosnell F (2004) The efficacy of facilitated tucking for relieving procedural pain of endotracheal suctioning in very low birthweight infants. Am J Matern Child Nurs 29:151-156
61. Watkins LR, Maier SF (2002) Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 82:981-1011
62. Winberg J (1998) Do neonatal pain and stress program the brain's response to future stimuli? Acta Paediatr 87:723-725