Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes

Breast Cancer Research and Treatment

Volumn 133, Issue 3, 2012, Pages 843-851

  Riaz, Muhammad ^a   Berns, Els M J J ^a   Sieuwerts, Anieta M ^a   Ruigrok Ritstier, Kirsten ^a   De Weerd, Vanja ^a   Groenewoud, Arwin ^a   Uitterlinden, Andrè G ^b   Look, Maxime P ^a   Klijn, Jan G M ^a   Sleijfer, Stefan ^a   Foekens, John A ^a,b   Martens, John W M ^a,b  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Breast cancer; Low risk loci; MRNA Expression; Prognosis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 2; GENOMIC DNA; MESSENGER RNA; MYC PROTEIN; PROGESTERONE RECEPTOR;

2Q35 GENE; ADULT; AGED; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER INHIBITION; CANCER PATIENT; CANCER PROGNOSIS; CANCER SUSCEPTIBILITY; CANCER TISSUE; CLINICAL FEATURE; COHORT ANALYSIS; FEMALE; FGFR2 GENE; GENE; GENE EXPRESSION; GENE LOCATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; H19 GENE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LSP1 GENE; MAJOR CLINICAL STUDY; MAP3K1 GENE; METASTASIS FREE SURVIVAL; POU5F1P1 GENE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL TIME; TOX3 GENE;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; GENE FREQUENCY; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; NEOPLASM METASTASIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 84863725615     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1663-3     Document Type: Article

References (27)

1. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D et al (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447:1087-1093
2. Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J et al (2007) Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 39:865-869
3. Turnbull C, Ahmed S, Morrison J, Pernet D, Renwick A et al (2010) Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 42:504-507
4. McInerney N, Colleran G, Rowan A, Walther A, Barclay E et al (2009) Low penetrance breast cancer predisposition SNPs are site specific. Breast Cancer Res Treat 117:151-159
5. Hemminki K, Muller-Myhsok B, Lichtner P, Engel C, Chen B et al (2010) Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients. Int J Cancer 126: 2858-2862
6. Liang J, Chen P, Hu Z, Shen H, Wang F et al (2010) Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population. Breast Cancer Res Treat 124:237-241
7. Meyer KB, Maia AT, O'Reilly M, Teschendorff AE, Chin SF et al (2008) Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol 6:e108
8. Sun C, Olopade OI, Di Rienzo A (2010) rs2981582 is associated with FGFR2 expression in normal breast. Cancer Genet Cyto-genet 197:193-194
9. McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M et al (2006) REporting recommendations for tumor MARKer prognostic studies (REMARK). Breast Cancer Res Treat 100:229-235
10. Foekens JA, Portengen H, van Putten WL, Peters HA, Krijnen HL et al (1989) Prognostic value of estrogen and progesterone receptors measured by enzyme immunoassays in human breast tumor cytosols. Cancer Res 49:5823-5828
11. Berns EM, Klijn JG, van Staveren IL, Portengen H, Noordegraaf E et al (1992) Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: correlation with steroid receptors. Eur J Cancer 28: 697-700
12. Hsieh SM, Look MP, Sieuwerts AM, Foekens JA, Hunter KW (2009) Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study. Breast Cancer Res 11:R75
13. Sieuwerts AM, Meijer-van Gelder ME, Timmermans M, Trapman AM, Garcia RR et al (2005) How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamox-ifen treatment in patients with recurrent breast cancer: a retrospective study. Clin Cancer Res 11:7311-7321
14. van Agthoven T, Sieuwerts AM, Meijer-van Gelder ME, Look MP, Smid M et al (2009) Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance. J Clin Oncol 27:542-549
15. Mavaddat N, Antoniou AC, Easton DF, Garcia-Closas M (2010) Genetic susceptibility to breast cancer. Mol Oncol 4:174-191
16. Ahmadiyeh N, Pomerantz MM, Grisanzio C, Herman P, Jia L et al (2010) 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci USA 107:9742-9746
17. Gold B, Kirchhoff T, Stefanov S, Lautenberger J, Viale A et al (2008) Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci USA 105:4340-4345
18. Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S et al (2009) A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet 41:579-584
19. Garcia-Closas M, Hall P, Nevanlinna H, Pooley K, Morrison J et al (2008) Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet 4:e1000054
20. Milne RL, Benitez J, Nevanlinna H, Heikkinen T, Aittomaki K et al (2009) Risk of estrogen receptor-positive and-negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst 101:1012-1018
21. Zhang Y, Martens JW, Yu JX, Jiang J, Sieuwerts AM et al (2009) Copy number alterations that predict metastatic capability of human breast cancer. Cancer Res 69:3795-3801
22. Tilghman SM (1999) The sins of the fathers and mothers: genomic imprinting in mammalian development. Cell 96:185-193
23. Tycko B, Efstratiadis A (2002) Genomic imprinting: piece of cake. Nature 417:913-914
24. Adnane J, Gaudray P, Dionne CA, Crumley G, Jaye M et al (1991) BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers. Onco-gene 6:659-663
25. Panagopoulos I, Moller E, Collin A, Mertens F (2008) The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. Oncol Rep 20:1029-1033
26. Kastler S, Honold L, Luedeke M, Kuefer R, Moller P et al (2010) POU5F1P1, a putative cancer susceptibility gene, is overexpres-sed in prostatic carcinoma. Prostate 70:666-674
27. Udler MS, Ahmed S, Healey CS, Meyer K, Struewing J et al (2010) Fine scale mapping of the breast cancer 16q12 locus. Hum Mol Genet 19:2507-2515