Donor age affects liver regeneration during early period in the graft liver and late period in the remnant liver after living donor liver transplantation

World Journal of Surgery

Volumn 36, Issue 5, 2012, Pages 1102-1111

  Tanemura, Akihiro ^a   Mizuno, Shugo ^a   Wada, Hideo ^a   Yamada, Tomomi ^a   Nobori, Tsutomu ^a   Isaji, Shuji ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; BIOLOGICAL MARKER; VON WILLEBRAND FACTOR;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; BLOOD; EVALUATION; FEMALE; GROWTH, DEVELOPMENT AND AGING; HUMAN; LIVER; LIVER DISEASE; LIVER REGENERATION; LIVER TRANSPLANTATION; LIVING DONOR; MALE; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; ORGAN SIZE; TIME; TREATMENT OUTCOME;

ADAM PROTEINS; ADOLESCENT; ADULT; AGE FACTORS; AGED; BIOLOGICAL MARKERS; FEMALE; HUMANS; LIVER; LIVER DISEASES; LIVER REGENERATION; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ORGAN SIZE; TIME FACTORS; TREATMENT OUTCOME; VON WILLEBRAND FACTOR; YOUNG ADULT;

EID: 84863725007     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-012-1496-1     Document Type: Article

References (45)

1. Busuttil RW, Tanaka K (2003) The utility of marginal donors in liver transplantation. Liver Transpl 9:651-663
2. Cuende N, Miranda B, Cañón JF et al (2005) Donor characteristics associated with liver graft survival. Transplantation 79:1445-1452
3. Feng S, Goodrich NP, Bragg-Gresham JL et al (2006) Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 6:783-790
4. Selzner M, Kashfi A, Selzner N et al (2009) Recipient age affects long-term outcome and hepatitis C recurrence in old donor livers following transplantation. Liver Transpl 15:1288-1295
5. Valadao RM, Terrault NA (2009) Older donors: mounting risks for the hepatitis C-infected liver transplant recipient? Liver Transpl 15:677-681
6. Santori G, Andorno E, Morelli N et al (2005) Impact of different cadaveric donor age cut-offs on adult recipient survival after liver transplantation: a single-center analysis. Transplant Proc 37: 2576-2581
7. Gastaca M, Valdivieso A, Pijoan J et al (2005) Donors older than 70 years in liver transplantation. Transplant Proc 37:3851-3854
8. Borchert DH, Glanemann M, Mogl M et al (2005) Adult liver transplantation using liver grafts from donors over 70 years of age. Transplant Proc 37:1186-1187
9. Cescon M, Grazi GL, Cucchetti A et al (2008) Improving the outcome of liver transplantation with very old donors with updated selection and management criteria. Liver Transpl 14: 672-679
10. Japanese Liver Transplantation Society (2009) Liver Transplantation in Japan - Registry by the Japanese Liver Transplantation Society 44:559-571
11. Ikegami T, Taketomi A, Ohta R et al (2008) Donor age in living donor liver transplantation. Transplant Proc 40:1471-1475
12. Akamatsu N, Sugawara Y, Tamura S et al (2007) Impact of live donor age (≥50) on liver transplantation. Transplant Proc 39: 3189-3193
13. Selzner M, Selzner N, Chen L et al (2009) Exaggerated up-regulation of tumor necrosis factor alpha-dependent apoptosis in the older mouse liver following reperfusion injury: targeting liver protective strategies to patient age. Liver Transpl 15:1594-1604
14. Suzuki A, Sakaguchi T, Inaba K et al. (2010) Impact of cell cycle disruption on impaired hepatic regeneration in aged livers with ischemic insult. J Surg Res. doi:10.1016/j.jss.2010.10.012
15. Chen WD, Wang YD, Zhang L et al (2010) Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology 51:953-962
16. Soejima K, Mimura N, Hirashima M et al (2001) A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease? J Biochem 130:475-480
17. Levy GG, Nichols WC, Lian EC et al (2001) Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature 413:488-494
18. Zheng X, Chung D, Takayama TK et al (2001) Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem 276:41059-41063
19. Plaimauer B, Zimmermann K, Völkel D et al (2002) Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13). Blood 100:3626-3632
20. Furlan M, Robles R, Solenthaler M et al (1997) Deficient activity of von Willebrand factor-cleaving protease in chronic relapsing thrombotic thrombocytopenic purpura. Blood 89:3097-3103
21. Moake JL (2002) Thrombotic microangiopathies. N Engl J Med 347:589-600
22. Okano E, Ko S, Kanehiro H et al (2010) ADAMTS13 activity decreases after hepatectomy, reflecting a postoperative liver dysfunction. Hepatogastroenterology 57:316-320
23. Kobayashi T, Wada H, Usui M et al (2009) Decreased ADAM-TS13 levels in patients after living donor liver transplantation. Thromb Res 124:541-545
24. Kokame K, Sakata T, Kokubo Y et al (2011) von Willebrand factor-to-ADAMTS13 ratio increases with age in a Japanese population. J Thromb Haemost 9:1426-1428
25. Hashikura Y, Ichida T, Umeshita K et al (2009) Donor complications associated with living donor liver transplantation in Japan. Transplantation 88:110-114
26. Kuramitsu K, Egawa H, Keeffe EB et al (2007) Impact of age older than 60 years in living donor liver transplantation. Transplantation 84:166-172
27. Yokoi H, Isaji S, Yamagiwa K et al (2005) Donor outcome and liver regeneration after right-lobe graft donation. Transpl Int 18: 915-922
28. Urata K, Kawasaki S, Matsunami H et al (1995) Calculation of child and adult standard liver volume for liver transplantation. Hepatology 21:1317-1321
29. Hirata M, Harihara Y, Kitamura T et al (2001) The influence of donor age to graft volume increase rate in living donor liver transplantation. Transplant Proc 33:1416-1417
30. Ikegami T, Nishizaki T, Yanaga K et al (2000) The impact of donor age on living donor liver transplantation. Transplantation 70:1703-1707
31. Iwamoto T, Yagi T, Umeda Y et al (2008) The impact of donor age on the outcome of adult living donor liver transplantation. Transplantation 85:1240-1245
32. Veteläinen R, van Vliet AK, van Gulik TM (2007) Severe steatosis increases hepatocellular injury and impairs liver regeneration in a rat model of partial hepatectomy. Ann Surg 245:44-50
33. Shah SA, Cattral MS, McGilvray ID et al (2007) Selective use of older adults in right lobe living donor liver transplantation. Am J Transplant 7:142-150
34. Soejima Y, Shimada M, Suehiro T et al (2003) Use of steatotic graft in living-donor liver transplantation. Transplantation 76:344-348
35. Dayangac M, Taner CB, Yaprak O et al (2011) Utilization of elderly donors in living donor liver transplantation: when more is less? Liver Transpl 17:548-555
36. Yagi S, Iida T, Taniguchi K et al (2005) Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantation. Liver Transpl 11:68-75
37. Pomfret EA, Pomposelli JJ, Gordon FD et al (2003) Liver regeneration and surgical outcome in donors of right-lobe liver grafts. Transplantation 76:5-10
38. Kwon KH, Kim YW, Kim SI et al (2003) Postoperative liver regeneration and complication in live liver donor after partial hepatectomy for living donor liver transplantation. Yonsei Med J 44:1069-1077
39. Kim SJ, Kim DG, Chung ES et al (2006) Adult living donor liver transplantation using the right lobe. Transplant Proc 38: 2117-2120
40. Kawasaki S, Makuuchi M, Ishizone S et al (1992) Liver regeneration in recipients and donors after transplantation. Lancet 339:580-581
41. Haga J, Shimazu M, Wakabayashi G et al (2008) Liver regeneration in donors and adult recipients after living donor liver transplantation. Liver Transpl 14:1718-1724
42. Lautt WW (2007) Regulatory processes interacting to maintain hepatic blood flow constancy: vascular compliance, hepatic arterial buffer response, hepatorenal reflex, liver regeneration, escape from vasoconstriction. Hepatol Res 37:891-903
43. Kawasaki T, Moriyasu F, Kimura T et al (1990) Portal hemodynamic changes from partial hepatectomy - quantitative analysis of portal flow before, during and after hepatectomy, using an Doppler ultrasound system. Nihon Shokakibyo Gakkai Zasshi 87:979-988
44. Morii Y, Kawano K, Kim YI et al (1999) Augmentative effect of cyclosporin A on rat liver regeneration: influence on hepatocyte growth factor and transforming growth factor-beta(1). Eur Surg Res 31:399-405
45. Starzl TE, Porter KA, Mazzaferro V et al (1991) Hepatotrophic effects of FK506 in dogs. Transplantation 51:67-70