P2Y receptors regulate proliferation of human pancreatic duct epithelial cells

Pancreas

Volumn 41, Issue 5, 2012, Pages 797-803

  Ko, Taei ^a   An, Hee Jung ^a   Ji, Young Geon ^a   Kim, Ok Jun ^a   Lee, Dong Hyeon ^a  

^a CHA University   (South Korea)

Author keywords

P2Y receptor; P2Y 1; P2Y 6; Pancreatic duct epithelial cell; Proliferation

Indexed keywords

4 (2 IODO 6 METHYLAMINO 9H PURIN 9 YL) 2 PHOSPHONOOXYBICYCLO[3.1.0]HEXANE 1 METHANOL; ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; BROXURIDINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; MRS2578; PHOSPHOLIPASE C; PROTEIN KINASE C; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; RNA; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ARTICLE; CELL ACTIVITY; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOASSAY; PANCREAS DUCT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BLOTTING, WESTERN; BORON COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYADENINE NUCLEOTIDES; EPITHELIAL CELLS; ESTRENES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; ISOTHIOCYANATES; MALEIMIDES; PANCREATIC DUCTS; PROTEIN KINASE C; PYRROLIDINONES; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2Y1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THIOUREA; TYPE C PHOSPHOLIPASES; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

EID: 84863719242     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31823ba3b3     Document Type: Article

References (36)

1. Burnstock G, Knight GE. Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol. 2004;240:31-304.
2. Lee DH, Park KS, Kim DR, et al. Dual effect of ATPon glucose-induced insulin secretion in HIT-T15 cells. Pancreas. 2008;37:302-308.
3. Lee DH, Kim EG, Park KS, et al. Characteristics of P2X7-like receptor activated by adenosine triphosphate in HIT-T15 cells. Pancreas. 2007;35:53-62.
4. Lee DH, Park KS, Kong ID, et al. Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines. BMC Immunol. 2006;7:22.
5. Burnstock G. Purine and pyrimidine receptors. Cell Mol Life Sci. 2007;64:1471-1483.
6. Novak I. Purinergic receptors in the endocrine and exocrine pancreas. Purinergic Signal. 2008;4:237-253.
7. Luo X, Zheng W, Yan M, et al. Multiple functional P2X and P2Y receptors in the luminal and basolateral membranes of pancreatic duct cells. Am J Physiol. 1999;277:C205-C215.
8. Hede SE, Amstrup J, Christoffersen BC, et al. Purinoceptors evoke different electrophysiological responses in pancreatic ducts. P2Y inhibits K (+) conductance, and P2X stimulates cation conductance. J Biol Chem. 1999;274:31784-31791.
9. Nguyen TD, Moody MW, Savard CE, et al. Secretory effects of ATP on nontransformed dog pancreatic duct epithelial cells. Am J Physiol. 1998;275:G104-G113.
10. Nguyen TD, Meichle S, Kim US, et al. P2Y (11), a purinergic receptor acting via cAMP, mediates secretion by pancreatic duct epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2001;280:G795-G804.
11. Hansen MR, Krabbe S, Novak I. Purinergic receptors and calcium signalling in human pancreatic duct cell lines. Cell Physiol Biochem. 2008;22:157-168.
12. Künzli BM, Berberat PO, Giese T, et al. Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease. Am J Physiol Gastrointest Liver Physiol. 2007;292:G223-G230.
13. Shabbir M, Burnstock G. Purinergic receptor-mediated effects of adenosine 5'-triphosphate in urological malignant diseases. Int J Urol. 2009;16:143-150.
14. Burnstock G. Purinergic signaling and vascular cell proliferation and death. Arterioscler Thromb Vasc Biol. 2002;22:364-373.
15. Greig AV, Linge C, Terenghi G, et al. Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. J Invest Dermatol. 2003;120:1007-1015.
16. Schafer R, Sedehizade F, Welte T, et al. ATP-and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells. Am J Physiol Lung Cell Mol Physiol. 2003;285:L376-L385.
17. Van Kolen K, Slegers H. Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y (12) receptor in C6 cells. FEBS J. 2006;273:1843-1854.
18. Choi KC, Tai CJ, Tzeng CR, et al. Adenosine triphosphate activates mitogen-activated protein kinase in pre-neoplastic and neoplastic ovarian surface epithelial cells. Biol Reprod. 2003;68:309-315.
19. Calvert RC, Shabbir M, Thompson CS, et al. Immunocytochemical and pharmacological characterisation of P2-purinoceptor-mediated cell growth and death in PC-3 hormone refractory prostate cancer cells. Anticancer Res. 2004;24:2853-2859.
20. Shabbir M, Ryten M, Thompson C, et al. Purinergic receptor-mediated effects of ATP in high-grade bladder cancer. BJU Int. 2008;101:106-112.
21. Wang Q, Wang L, Feng YH, et al. P2X7 receptor-mediated apoptosis of human cervical epithelial cells. Am J Physiol Cell Physiol. 2004;287:C1349-C1358.
22. Maaser K, Höpfner M, Kap H, et al. Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y (2)-receptors. Br J Cancer. 2002;86:636-644.
23. Lieber M, Mazzetta J, Nelson-Rees W, et al. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer. 1975;15:741-747.
24. Lee DH, Ko JJ, Ji YG, et al. Proteomic identification of RREB1, PDE6B, and CD209 up-regulated in primitive gut tube differentiated from human embryonic stem cells. Pancreas. 2012;41:65-73.
25. Abbracchio MP, Burnstock G, Boeynaems JM, et al. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006;58:281-341.
26. Amadio S, D'Ambrosi N, Cavaliere F, et al. P2 receptor modulation and cytotoxic function in cultured CNS neurons. Neuropharmacology. 2002;42:489-501.
27. Sholl-Franco A, Fragel-Madeira L, Macama Ada C, et al. ATP controls cell cycle and induces proliferation in the mouse developing retina. Int J Dev Neurosci. 2010;28:63-73.
28. Franke H, Krügel U, Grosche J, et al. P2Y receptor expression on astrocytes in the nucleus accumbens of rats. Neuroscience. 2004;127:431-441.
29. Pines A, Bivi N, Vascotto C, et al. Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway. J Cell Physiol. 2006;209:44-55.
30. Resende RR, Britto LR, Ulrich H. Pharmacological properties of purinergic receptors and their effects on proliferation and induction of neuronal differentiation of P19 embryonal carcinoma cells. Int J Dev Neurosci. 2008;26:763-777.
31. Coutinho-Silva R, Stahl L, Cheung KK, et al. P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2005;288:G1024-G1035.
32. White N, Ryten M, Clayton E, et al. P2Y purinergic receptors regulate the growth of human melanomas. Cancer Lett. 2005;224:81-91.
33. Sellers LA, Simon J, Lundahl TS, et al. Adenosine nucleotides acting at the human P2-1 receptor stimulate mitogen-activated protein kinases and induce apoptosis. J Biol Chem. 2001;276:16379-16390.
34. Hou M, Harden TK, Kuhn CM, et al. UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y (6) receptors. Am J Physiol Heart Circ Physiol. 2002;282:H784-H792.
35. Milosevic J, Brandt A, Roemuss U, et al. Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling. J Neurochem. 2006;99:913-923.
36. Lee YM, Chen WF, Chou DS, et al. Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation. J Biomed Sci. 2010;17:45.