Cancer stem cell marker Bmi-1 expression is associated with basal-like phenotype and poor survival in breast cancer

World Journal of Surgery

Volumn 36, Issue 5, 2012, Pages 1189-1194

  Wang, Yanyang ^a   Zhe, Hong ^a   Ding, Zhe ^a   Gao, Ping ^a   Zhang, Ningmei ^a   Li, Guofu ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; REPRESSOR PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BREAST TUMOR; CANCER GRADING; FEMALE; FOLLOW UP; HUMAN; LUNG CARCINOMA; METABOLISM; MIDDLE AGED; MORTALITY; PAGET NIPPLE DISEASE; PATHOLOGY; PHENOTYPE; PROGNOSIS; SURVIVAL;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; NEOPLASM GRADING; NUCLEAR PROTEINS; PHENOTYPE; PROGNOSIS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84863717532     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-012-1514-3     Document Type: Article

References (35)

1. Perou CM, Sorlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406:747-752
2. Sorlie T, Perou CM, Tibshirani R et al (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874
3. Sorlie T, Tibshirani R, Parker J et al (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 100:8418-8423
4. Sotiriou C, Neo SY, McShane LM et al (2003) Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A 100: 10393-10398
5. Shipitsin M, Campbell LL, Argani P et al (2007) Molecular definition of breast tumor heterogeneity. Cancer Cell 11:259-273
6. Rakha EA, Reis-Filho JS, Ellis IO (2008) Basal-like breast cancer: a critical review. J Clin Oncol 26:2568-2581
7. Badve S, Dabbs DJ, Schnitt SJ et al (2011) Basal-like and triplenegative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol 24: 157-167
8. Haupt Y, Alexander WS, Barri G et al (1991) Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 65:753-763
9. van Lohuizen M, Verbeek S, Scheijen B et al (1991) Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65:737-752
10. van der Lugt NM, Domen J, Linders K et al (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8:757-769
11. Pirrotta V (1998) Polycombing the genome: PcG, trxG, and chromatin silencing. Cell 93:333-336
12. Lessard J, Sauvageau G (2003) Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423: 255-260
13. Liu S, Dontu G, Mantle ID et al (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66:6063-6071
14. Jiang L, Li J, Song L (2009) Bmi-1, stem cells and cancer. Acta Biochim Biophys Sin (Shanghai) 41:527-534
15. Kim JH, Yoon SY, Jeong SH et al (2004) Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. Breast 13:383-388
16. Feng Y, Song LB, Guo BH et al (2007) Expression and significance of Bmi-1 in breast cancer. Ai Zheng 26:154-157
17. Arnes JB, Collett K, Akslen LA (2008) Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1. Histopathology 52:370-380
18. Choi YJ, Choi YL, Cho EY et al (2009) Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients. Breast Cancer Res Treat 113:83-93
19. Honig A, Weidler C, Häusler S et al (2010) Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer. Anticancer Res 30:1559-1564
20. Riis ML, Lüders T, Nesbakken AJ et al (2010) Expression of BMI-1 and Mel-18 in breast tissue: a diagnostic marker in patients with breast cancer. BMC Cancer 10:686
21. Guo BH, Feng Y, Zhang R et al (2011) Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer 10:10
22. Joensuu K, Hagström J, Leidenius M et al (2011) Bmi-1, c-myc, and Snail expression in primary breast cancers and their metastases-elevated Bmi-1 expression in late breast cancer relapses. Virchows Arch 459:31-39
23. Vonlanthen S, Heighway J, Altermatt HJ et al (2001) The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br J Cancer 84:1372-1376
24. Kim JH, Yoon SY, Kim CN et al (2004) The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Cancer Lett 203:217-224
25. Song W, Tao K, Li H et al (2010) Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer. Cancer Sci 101:1754-1760
26. Zhang X, Wang CX, Zhu CB et al (2010) Overexpression of Bmi-1 in uterine cervical cancer: correlation with clinicopathology and prognosis. Int J Gynecol Cancer 20:1597-1603
27. Nielsen TO, Hsu FD, Jensen K et al (2004) Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 10:5367-5374
28. Campbell LL, Polyak K (2007) Breast tumor heterogeneity: cancer stem cells or clonal evolution? Cell Cycle 6:2332-2338
29. Shackleton M, Quintana E, Fearon ER et al (2009) Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138:822-829
30. Polyak K, Hahn WC (2006) Roots and stems: stem cells in cancer. Nat Med 12:296-300
31. Visvader JE, Lindeman GJ (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8:755-768
32. Rosen JM, Jordan CT (2009) The increasing complexity of the cancer stem cell paradigm. Science 324:1670-1673
33. Pece S, Tosoni D, Confalonieri S et al (2010) Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 140:62-73
34. Park SY, Lee HE, Li H et al (2010) Heterogeneity for stem cellrelated markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res 16:876-887
35. Kakarala M, Wicha MS et al (2008) Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol 26:2813-2820