Testicular toxicity and sperm quality following cadmium exposure in rats: Ameliorative potentials of Allium cepa

Journal of Human Reproductive Sciences

Volumn 5, Issue 1, 2012, Pages 37-42

  Ige, Serah ^a   Olaleye, Samuel ^b   Akhigbe, Roland ^a   Akanbi, Titilayo ^a   Oyekunle, Olanrewaju ^a   Udoh, Utibe Abasi ^a  

^a LADOKE AKINTOLA UNIVERSITY OF TECHNOLOGY   (Nigeria)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Allium cepa; cadmium sulfate; oxidative stress; testes

Indexed keywords

CADMIUM SULFATE; CATALASE; ONION EXTRACT; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; ONION; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; RAT; SEMEN ANALYSIS; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS DISEASE; TESTIS WEIGHT; TREATMENT DURATION;

EID: 84863704332     PISSN: 09741208     EISSN: 19984766     Source Type: Journal    
DOI: 10.4103/0974-1208.97798     Document Type: Article

References (38)

1. Kido T, Nogawa K, Yamada Y, Honda R, Tsuritani I, Ishizaki M, et al. Osteopenia in inhabitants with renal dysfunction induced by exposure to environmental cadmium. Int Arch Occup Environ Health 1989;61:271-6.
2. Cherian MG, O'Heany J, Kusiak RA. Health effects of cadmium and its inorganic compounds. Toronto: Ontario Ministry of Labour;1985.
3. Adams RG. Manufacturing process, resultant risk profiles and their control in the production of nickel-cadmium (alkaline) batteries. Occup Med 1992;42:101-6.
4. Ellis KJ, Cohn SH, Smith TJ. Cadmium inhalation exposure estimates their significance with respect to kidney and liver cadmium burden. J Toxicol Environ Health 1985;15:173-87.
5. Elinder CG, Edling C, Lindberg E, Kagedal B, Vesterberg O. Assessment of renal function in workers previously exposed to cadmium. Br J Ind Med 1985;42:754-60.
6. Zwennis WC, Franssen AC. Assessment of occupational exposure to cadmium in the Netherlands, 1980-1989. Am J Ind Med 1992;21:793-805.
7. Syers JK, Mackay AD, Brown MW, Currie CD. Chemical and physical characteristics of phosphate rock materials of varying reactivity. J Sci Food Agric 1986;37:1057-64.
8. Trueman NA. The phosphate, volcanic and carbonate rocks of Christmas Island (Indian Ocean). J Geol Soc Aust 1965;12:261-86.
9. Taylor MD. Accumulation of Cadmium derived from fertilizers in New Zealand soils. Sci Total Environ 1997;208:123-6.
10. Shuenn JY, Chern CL, Jenn YS, Lin TH. Cadmium induced lipid peroxidation in rats testes and protection by selenium. Biometals 2004;12:353-9.
11. Boscolo P, Sacchettoni-Logroscino G, Ranellete FO, Gioia A, Carmigani M. Effects of long term cadmium exposure on the testes of rabbits. Ultrastructural study. Toxicol Lett 1985;24:145-9.
12. Dorant E, Van den Brandt PA, Goldbohm AR. Prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. Carcinogenesis 1996;17:477-84.
13. Cavagnaro PF, Sance MM, Galmarini CR. Effect of heating on Onion (Allium cepa L.) antiplatelet activity and pungency sensory perception. Food Sci Technol Int 2007;13:447-53.
14. De Whalley CV, Rankin SM, Hoult JR, Jussup W, Leake DS. Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. Biomed Pharmacol 1990;39:1743-50.
15. Helen A, Krishnakumar K, Vijayammal PL, Augusti KT. Antioxidant effect of onion oil (Allium cepa Linn) on the damages induced by nicotine in rat as compared to alpha-tocopherol. Toxicology 2000;116:61-8.
16. Prakash D, Singh BN, Upadhyay G. Antioxidant and free radical scavenging activities of phenols from onion (Allium cepa). Food Chem 2007;102:1389-93.
17. Ige SE, Salawu EO, Olaleye SB, Adeeyo OA, Badmus J, Adeteke AA. Onion (Alluim cepa) extract prevents cadmium-induced renal dysfunction. Indian J Nephrol 2009;19:140-4.
18. Videla LA. Assessment of the scavenging action of reduced glutathione (+) cianidanol-3 and ethanol by the chemiluminescent response of the xanthine oxidase reaction. Experientia 1983;39:500-2.
19. Videla LA, Fernandez V, Valenzuela A, Ugarte G. Effect of (+) -cianidanol-3 on the changes in liver glutathione content and lipoperoxidation induced by acute ethanol administration in the rat. Pharmacology 1981;22:343-8.
20. Younes M, Siegers CP. Inhibitory action of some flavonoids on enhanced spontaneous lipid peroxidation following glutathione depletion. Planta Med 1981;43:240-4.
21. Muller A, Sies H. Role of alcohol dehydrogenase activity and of acetaldehyde in ethane and pentane production by isolated perfused rat liver. Biochem J 1982;206:153-6.
22. Valenzuela A, Guerra R. Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced acrosomal lipid peroxidation. Experientia 1986;42:139-41.
23. Azu NC, Onyeagba RA, Nworie O, Kalu J. Antibacterial activity of allium cepa (Onions) and zingiber officinale (Ginger) on staphylococcus aureus and Pseudomonas aeruginosa isolated from high vaginal swab. Internet J Trop Med 2007;3:2.
24. Morrisey RE, Schwctz BA, James C, Monica DR, Teague JL, Moris RW. Evaluation of rodent sperm, vagina cytology and Reproductive organ weight from National Toxicology Programme-13 weeks studies. Fundam Appl Toxicol 1988;11:343-58.
25. Freund M, Carol B. Factors affecting haemocytometer count of sperm concentration in human semen. J Reprod Fertil 1964;8:149-52.
26. Jiang ZY, Woolland AC, Wolff SP. Hydrogen peroxide production during experimental protein glycation. FEBS Lett 1972;268:69-71.
27. Fridovich I, Misra HP. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972;247:3170-5.
28. Varshney R, Kale RK. Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. Int J Radiat Biol 1990;58:733-43.
29. Akpantah AO, Oremosu AA, Ajala MO, Noronha CC, Okanlawon A. The effect of crude extract of Garcinia kola seed on the histology hormonal milieu of male Sprague dawley rats'reproductive organs. Nig J Health Biomed Sci 2003:2:40-6.
30. Garside DA, Harvey PW. Endocrine toxicology of the male reproductive system. In: Atterwill CK, Flack JD, editors. Endocrine Toxicology. Cambridge: Cambridge University Press; 1992. p. 285-312.
31. Li LH, Heindel JJ. Sertoli cell toxicants. In: Korach KS, editor. Reproductive and Developmental Toxicology. New York: Marcel Dekker; 1998. p. 655-91.
32. Pasqualotto FF, Locambo CV, Ahayde KS, Arap S. Measuring male infertility:epidemiological aspects. Rev Hosp Clin Fac Med Sao Paulo 2003;58:173-8.
33. Aydos K, Güven MC, Can B, Ergün A. Nicotine toxicity to the ultrastructure of the testis in rats. BJU Int 2001;88:622-6.
34. Fraga CG, Motchnik PA, Shigenaga MK, Helbock HJ, Jacob RA, Ames BN. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A 1991;88:11003-6.
35. Suleiman SA, Ali ME, Zaki ZM. Lipid peroxidation and human sperm motility: Protective role of vitamin E. J Androl 1996;17:530-7.
36. Letan AJ. The relation of structure to antioxidant activity of quercetin and some of its derivatives. II. Secondary (metal-complexing) activity. J Food Sci 1966;31:395-9.
37. Ige SF, Akhigbe RE, Adewale AA, Badmus JA, Olaleye SB, Ajao FO, et al. Effect of Allium cepa (Onion) extract on Cadmium-induced nephrotoxicity in rats. Kidney Res J 2011;1:41-7.
38. Ige SF, Akhigbe RE, Edeogho O, Ajao FO, Owolabi OQ, Oyekunle OS, et al. Hepatoprotective activities of Allium cepa in cadmium-treated rats. Int J Pharm Pharm Sci 3:60-3.