Adrenergic stimulation-released 5-HT stored in adrenergic nerves inhibits CGRPergic nerve-mediated vasodilatation in rat mesenteric resistance arteries

British Journal of Pharmacology

Volumn 166, Issue 7, 2012, Pages 2084-2094

  Fujii, Hirohito ^a   Takatori, Shingo ^a   Zamami, Yoshito ^a   Hashikawa Hobara, Narumi ^b   Miyake, Natsuki ^a   Tangsucharit, Panot ^a   Mio, Mitsunobu ^c   Kawasaki, Hiromu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

^c SHUJITSU UNIVERSITY   (Japan)

Author keywords

5 HT; adrenergic nerve; calcitonin gene related peptide containing nerves; perivascular nerve interaction; rat mesenteric artery

Indexed keywords

3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL] 1,1 DIPHENYL 2 PROPANOL; CALCITONIN GENE RELATED PEPTIDE; DESIPRAMINE; FLUOXETINE; GUANETHIDINE; METHYSERGIDE; SEROTONIN;

ADRENERGIC NERVE; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL REACTIVITY; CALCITONIN GENE RELATED PEPTIDE CONTAINING NERVE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MESENTERIC ARTERY; NERVE; NERVE ENDING; NERVE FUNCTION; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; STIMULUS RESPONSE; SYMPATHETIC NERVE; VASOCONSTRICTION; VASODILATATION;

ADRENERGIC AGENTS; ADRENERGIC NEURONS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; DESIPRAMINE; FLUOXETINE; GUANETHIDINE; MALE; MESENTERIC ARTERIES; METHOXAMINE; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; VASOCONSTRICTION; VASODILATION;

EID: 84863681656     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01935.x     Document Type: Article

References (15)

1. Carmichael NM, Chariton MP, Dostrovsky JO, (2008). Activation of the 5-HT1B/D receptor reduces hindlimb neurogenic inflammation caused by sensory nerve stimulation and capsaicin. Pain 134: 97-105.
2. Eguchi S, Tezuka S, Hobara N, Akiyama S, Kurosaki Y, Kawasaki H, (2004). Vanilloid receptors mediate adrenergic nerve- and CGRP-containing nerve-dependent vasodilation induced by nicotine in rat mesenteric resistance arteries. Br J Pharmacol 142: 1137-1146.
3. Kawasaki H, Takasaki K, (1984). Vasoconstrictor response induced by 5-hydroxytryptamine released from vascular adrenergic nerves by periarterial nerve stimulation. J Pharmacol Exp Ther 229: 816-822.
4. Kawasaki H, Takasaki K, (1986). Pharmacological characterization of presynaptic α-adrenoceptors in the modulation of the 5-hydroxytryptamine release from vascular adrenergic nerves in the rat. Jpn J Pharmacol 42: 561-570.
5. Kawasaki H, Takasaki K, Saito A, Goto K, (1988). Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 335: 164-167.
6. Kawasaki H, Urabe M, Takasaki K, (1989). Presynaptic α2- adrenoceptor modulation of 5-hydroxytryptamine and noradrenaline release from vascular adrenergic nerves. Eur J Pharmacol 164: 35-43.
7. Kawasaki H, Saito A, Takasaki K, (1990). Age-related calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessels of the spontaneously hypertensive rat. Circ Res 67: 733-743.
8. Kawasaki H, Nuki C, Saito A, Takasaki K, (1991). NPY modulates neurotransmission of CGRP-containing vasodilator nerves in rat mesenteric arteries. Am J Physiol 261: H683-H690.
9. Kawasaki H, Eguchi S, Miyashita S, Chan S, Hirai K, Hobara N, et al,. (2009). Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery. J Pharmacol Exp Ther 330: 745-755.
10. Ma QP, Hill R, Sirinathsinghji D, (2001). Colocalization of CGRP with 5-HT1B/D receptors and substance P in trigeminal ganglin neurons in rats. Eur J Neurosci 13: 2099-2104.
11. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
12. Panconesi A, (2008). Serotonin and migraine: a reconsideration of the central theory. J Headache Pain 9: 268-276.
13. Shiraki H, Kawasaki H, Tezuka S, Nakatsuma A, Kurosaki Y, (2000). Endogenous calcitonin gene-related peptide (CGRP) mediates adrenergic dependent vasodilation induced by nicotine in mesenteric resistance arteries of the rat. Br J Pharmacol 130: 1083-1091.
14. Takenaga M, Kawasaki H, Wada A, Eto T, (1995). Calcitonin gene-related peptide mediates acetylcholine-induced endothelium-independent vasodilation in mesenteric resistance blood vessels of the rat. Circ Res 76: 935-941.
15. Urabe M, Kawasaki H, Takasaki K, (1991). Effect of endothelium removal on the vasoconstrictor response to neuronally released 5-hydroxytryptamine and noradrenaline in the rat isolated mesenteric and femoral arteries. Br J Pharmacol 102: 85-90.