A Clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Roeder, Falk ^a,b   Schulz Ertner, Daniela ^d   Nikoghosyan, Anna V ^c   Huber, Peter E ^a,b   Edler, Lutz ^a   Habl, Gregor ^b   Krempien, Robert ^c   Oertel, Susanne ^a,b   Saleh Ebrahimi, Ladan ^a,b   Hensley, Frank W ^b   Buechler, Markus W ^b   Debus, Juergen ^a,b   Koch, Moritz ^b   Weitz, Juergen ^b   Bischof, Marc ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Helios Clinic Berlin   (Germany)

^d Markus Clinic   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL PROTOCOL; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; GASTROINTESTINAL TOXICITY; GOOD CLINICAL PRACTICE; HUMAN; INTENSITY MODULATED RADIATION THERAPY; INTRAOPERATIVE RADIOTHERAPY; LEUKOPENIA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; RADIATION DOSE; RETROPERITONEAL SARCOMA; SOFT TISSUE SARCOMA; ADJUVANT THERAPY; METHODOLOGY; PEROPERATIVE CARE; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); RETROPERITONEAL TUMOR; SARCOMA;

CLINICAL TRIALS, PHASE I AS TOPIC; CLINICAL TRIALS, PHASE II AS TOPIC; HUMANS; INTRAOPERATIVE CARE; NEOADJUVANT THERAPY; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; RADIOTHERAPY, INTENSITY-MODULATED; RETROPERITONEAL NEOPLASMS; SARCOMA;

EID: 84863678907     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-287     Document Type: Article

References (23)

1. Brennan MF, Casper ES, Harrison LB, Shiu MH, Gaynor J, Hajdu SI. The role of multimodality therapy in soft tissue sarcomas. Ann Surg 1991, 214:328-336. 10.1097/00000658-199109000-00015, 1358657, 1929613.
2. Catton CN, OSullivan B, Kotwall C, Cummings B, Hao Y, Fornasier V. Outcome and prognosis in retroperitoneal soft tissue sarcoma. Int J Radiat Oncol Biol Phys 1994, 29:1005-1010. 10.1016/0360-3016(94)90395-6, 8083069.
3. Petersen IA, Haddock MG, Donohue JH, Nagorney DM, Grill J, Sargent DJ, Gunderson LL. Use of intraoperative electron beam radiotherapy in the management of retroperitoneal soft tissue sarcomas. Int J Radiat Oncol Biol Phys 2002, 52:469-475. 10.1016/S0360-3016(01)02595-0, 11872294.
4. Heslin MJ, Lewis JJ, Nadler E, Newman E, Woodruff JM, Casper ES, Leung D, Brennan MF. Prognostic factors associated with long-term survival for retroperitoneal sarcoma: implications for management. J Clin Oncol 1997, 15:2832-2839.
5. Gronchi A, Casali PG, Fiore M, Mariani L, Lo Vullo S, Bertulli R, Colecchia M, Lozza L, Olmi P, Santinami M, Rosai J. Retroperitoneal soft tissue sarcomas. Patterns of recurrence in 167 patients treated at a single institution. Cancer 2004, 100:2448-2455. 10.1002/cncr.20269, 15160351.
6. Lewis JJ, Leung D, Woodruff JM, Brennan MF. Retroperitoneal soft-tissue sarcoma: Analysis of 500 patients treated and followed at a single institution. Ann Surg 1998, 228:355-365. 10.1097/00000658-199809000-00008, 1191491, 9742918.
7. Stoeckle E, Coindre JM, Bonvalot S, Kantor G, Terrier P, Bonichon F, Nguyen Bui B, . French Federation of Cancer Centers Sarcoma Group Prognostic factors in retroperitoneal sarcoma: A multivariate analysis of a series of 165 patients of the French Cancer Center Federation Sarcoma Group. Cancer 2001, 92:359-368. 10.1002/1097-0142(20010715)92:2<359::AID-CNCR1331>3.0.CO;2-Y, 11466691, French Federation of Cancer Centers Sarcoma Group.
8. Pisters PWT, Harrison LB, Leung DH, Woodruff JM, Casper ES, Brennan MF. Long term results of a prospective randomized trial evaluating the role of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol 1996, 14:859-868.
9. Yang JC, Chang AE, Baker AR, Sindelar WF, Danforth DN, Topalian SL, DeLaney T, Glatstein E, Steinberg SM, Merino MJ, Rosenberg SA. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft-tissue sarcomas of the extremity. J Clin Oncol 1998, 16:197-203.
10. Krempien R, Roeder F, Oertel S, Weitz J, Hensley FW, Timke C, Funk A, Lindel K, Harms W, Buchler MW, Debus J, Treiber M. Intraoperative electron-beam therapy for primary and recurrent retroperitoneal soft-tissue sarcoma. Int J Radiat Biol Oncol Phys 2006, 65:773-779.
11. Tepper JE, Suit HD, Wood WC, Proppe KH, Harmon D, McNulty P. Radiation therapy of retroperitoneal soft tissue sarcomas. Int J Radiat Oncol Biol Phys 1984, 10:825-830. 10.1016/0360-3016(84)90383-3, 6735766.
12. Fein DA, Corn BW, Lanciano RM, Herbert SH, Hoffman JP, Coia LR. Management of retroperitoneal sarcomas: Does dose escalation impact on locoregional control ?. Int J Radiat Oncol Biol Phys 1995, 31:129-134. 10.1016/0360-3016(94)E0302-Z, 7995743.
13. Sindelar WF, Kinsella TJ, Chen PW, DeLaney TF, Tepper JE, Rosenberg SA, Glatstein E. Intraoperative radiotherapy in retroperitoneal sarcomas. Final results of a prospective, randomized clinical trial. Arch Surg 1993, 128:402-410. 10.1001/archsurg.1993.01420160040005, 8457152.
14. Gieschen HL, Spiro IJ, Suit HD, Ott MJ, Rattner DW, Ancukiewicz M, Wilett CG. Long-term results of intraoperative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma. Int J Radiat Oncol Biol Phys 2001, 50:127-131. 10.1016/S0360-3016(00)01589-3, 11316555.
15. Alektiar KM, Hu K, Anderson L, Brennan MF, Harrison LB. High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys 2000, 47:157-163. 10.1016/S0360-3016(99)00546-5, 10758318.
16. Shaw EG, Gunderson LL, Martin JK, Beart RW, Nagorney DM, Podratz KC. Peripheral nerve and ureteral tolerance to intraoperative radiation therapy: Clinical and dose-response analysis. Radiother Oncol 1990, 18:247-255. 10.1016/0167-8140(90)90060-A, 2171042.
17. Musat E, Kantor G, Caron J, Lagarde P, Laharie H, Stoeckle E, Angles J, Gilbeau L, Bui BN. Comparison of intensity-modulated postoperative radiotherapy with conventional postoperative conformal radiotherapy for retroperitoneal sarcoma. Cancer Radiother 2004, 8:255-261. 10.1016/j.canrad.2004.05.001, 15450519.
18. Lohr F, Dobler B, Mai S, Hermann B, Tiefenbacher U, Wieland P, Steil V, Wenz F. Optimization of dose distributions for adjuvant locoregional radiotherapy of gastric cancer by IMRT. Strahlenther Onkol 2003, 179:557-563. 10.1007/s00066-003-1087-z, 14509955.
19. Pirzkall A, Carol M, Lohr F, Höss A, Wannenmacher M, Debus J. Comparison of intensity-modulated radiotherapy with conventional conformal radiotherapy for complex-shaped tumors. Int J Radiat Oncol Biol Phys 2000, 48:1371-1380. 10.1016/S0360-3016(00)00772-0, 11121636.
20. Lohr F, Debus J, Frank C, Herfarth K, Pastyr O, Rhein B, Bahner ML, Schlegel W, Wannenmacher M. Noninvasive patient fixation for extracranial stereotactic radiotherapy. Int J Radiat Oncol Biol Phys 1999, 45:521-527. 10.1016/S0360-3016(99)00190-X, 10487580.
21. Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, Shank B, Solin LJ, Wesson M. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991, 21:109-122.
22. Chow SC, Shao J, Wang H. Sample sizes in clinical research 2003, Marcel Dekker Inc, New York.
23. Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials 1989, 10:1-10. 10.1016/0197-2456(89)90015-9, 2702835.