The effect of astragalin on the VEGF production of cultured Müller cells under high glucose conditions

Bio-Medical Materials and Engineering

Volumn 22, Issue 1-3, 2012, Pages 113-119

  Ke, Min ^a   Hu, Xin Qian ^b   Ouyang, Jingping ^c   Dai, Bo ^a   Xu, Yancheng ^c  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b ZHEJIANG HOSPITAL   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

astragalin; Diabetic retinopathy; retinal M ller cells; vascular endothelial growth factor

Indexed keywords

ASTRAGALIN; ASTRAGALUS MEMBRANACEUS; BENEFICIAL EFFECTS; BIOLOGICAL FACTORS; DIABETES MELLITUS; DIABETIC RETINOPATHY; FOUR-GROUP; IMMUNOCYTOCHEMISTRY; IN-VITRO; MECHANISM OF ACTION; NORMAL CONTROLS; OVER-EXPRESSION; PHARMACOLOGICAL PROPERTIES; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIAL GROWTH FACTOR; VISION LOSS;

CYTOLOGY; EYE PROTECTION; GLUCOSE; POLYMERASE CHAIN REACTION;

CELLS;

ASTRAGALUS MEMBRANACEUS; RATTUS;

ASTRAGALIN; GLUCOSE; KAEMPFEROL DERIVATIVE; MESSENGER RNA; VASCULOTROPIN A;

ANIMAL; ARTICLE; ASTRAGALUS PLANT; CELL CULTURE; CHEMISTRY; CYTOLOGY; DIABETIC RETINOPATHY; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; RAT; RETINA; UPREGULATION;

ANIMALS; ASTRAGALUS PLANT; CELLS, CULTURED; DIABETIC RETINOPATHY; GLUCOSE; KAEMPFEROLS; RATS; RETINA; RNA, MESSENGER; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863659113     PISSN: 09592989     EISSN: None     Source Type: Journal    
DOI: 10.3233/BME-2012-0696     Document Type: Conference Paper

References (14)

1. F.B. Valiatti, D. Crispim, C. Benfica, B.B. Valiatti, C.K. Kramer and L.H. Canani, The role of vascular endothelial growth factor in angiogenesis and diabetic retinopathy, Arq. Bras. Endocrinol. Metabol. 55 (2011), 106-113.
2. G. Costa, T. Pereira, A.M. Neto, A.J. Cristovao, A.F. Ambrosio and P.F. Santos, High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures, J. Neurosci. Res. 87 (2009), 1375-1380.
3. O. Arjamaa and M. Nikinmaa, Oxygen-dependent diseases in the retina: role of hypoxia-inducible factors, Exp. Eye Res. 83 (2006), 473-483.
4. R.N. Frank, Treating diabetic retinopathy by inhibiting growth factor pathways, Curr. Opin. Invest. Drugs 10 (2009), 327-335.
5. J.H. Kim, J.H. Kim, Y.S. Yu, C.S. Cho and K.W. Kim, Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy, J. Cereb. Blood Flow Metab. 29 (2009), 621-628.
6. H.L. Deissler and G.E. Lang, Effect of VEGF165 and the VEGF aptamer pegaptanib (Macugen) on the protein composition of tight junctions in microvascular endothelial cells of the retina, Klin. Monbl. Augenheilkd. 225 (2008), 863-867.
7. K. Shinoda, R. Rejdak, F. Schuettauf, G. Blatsios, M. Volker, N. Tanimoto, T. Olcay, F. Gekeler, C. Lehaci, R. Naskar, Z. Zagorski and E. Zrenner, Early electroretinographic features of streptozotocin-induced diabetic retinopathy, Clin. Exper. Ophthalmol. 35 (2007), 847-854.
8. X.Q. Mao, F. Yu, N. Wang, Y. Wu, F. Zou, K. Wu, M. Liu and J.P. Ouyang, Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism, Phytomedicine 16 (2009), 416-425.
9. Y. Wu, J.P. Ou-Yang, K. Wu, Y. Wang, Y.F. Zhou and C.Y. Wen, Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B, Acta Pharmacol. Sin. 26 (2005), 345-352.
10. X.Q. Mao, Y. Wu, K. Wu, M. Liu, J.F. Zhang, F. Zou and J.P. Ou-Yang, Astragalus polysaccharide reduces hepatic endoplasmic reticulum stress and restores glucose homeostasis in a diabetic KKAy mouse model, Acta Pharmacol. Sin. 28 (2007), 1947-1956.
11. R.J. Li, S.D. Qiu, H.X. Chen, H. Tian and H.X. Wang, The immunotherapeutic effects of Astragalus polysaccharide in type 1 diabetic mice, Biol. Pharm. Bull. 30 (2007), 470-476.
12. N.S. Umapathy, W. Li, B.A. Mysona, S.B. Smith and V. Ganapathy, Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Muller cells, Invest. Ophthalmol. Vis. Sci. 46 (2005), 3980-3987.
13. E.C. Yego, J.A. Vincent, V. Sarthy, J.V. Busik and S. Mohr, Differential regulation of high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation in Muller cells by IL-1beta and IL-6, Invest. Ophthalmol. Vis. Sci. 50 (2009), 1920-1928.
14. R. Simo and C. Hernandez, Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy, Diabetologia 51 (2008), 1574-1580.