Former hand territory activity increases after amputation during intact hand movements, but is unaffected by illusory visual feedback

Neurorehabilitation and Neural Repair

Volumn 26, Issue 6, 2012, Pages 604-615

  Bogdanov, Sergei ^a   Smith, Jolinda ^a   Frey, Scott H ^a,b  

^a UNIVERSITY OF OREGON   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

cortical reorganization; mirror therapy; motor imagery; phantom limb pain; upper extremity amputation

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HAND AMPUTATION; HAND FUNCTION; HAND MOVEMENT; HEMISPHERE; HUMAN; ILLUSION; MALE; MIRROR THERAPY; MOTOR CORTEX; PHYSIOTHERAPY; PREMOTOR CORTEX; SENSORIMOTOR FUNCTION; VISUAL FEEDBACK;

AGED; AMPUTEES; ANALYSIS OF VARIANCE; BRAIN MAPPING; CEREBRAL CORTEX; FEEDBACK, SENSORY; FEMALE; FUNCTIONAL LATERALITY; HAND; HUMANS; ILLUSIONS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGERY (PSYCHOTHERAPY); IMAGINATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOVEMENT; OXYGEN;

EID: 84863653772     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968311429687     Document Type: Article

References (58)

1. Kaas JH. Plasticity of sensory and motor maps in adult mammals. Annu Rev Neurosci. 1991 ; 14: 137-167
2. Sanes JN, Donoghue JP. Plasticity and primary motor cortex. Annu Rev Neurosci. 2000 ; 23: 393-415
3. Jenkins WM, Merzenich MM, Ochs MT, Allard T, Guic-Robles E. Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation. J Neurophysiol. 1990 ; 63: 82-104
4. Nudo RJ, Milliken GW, Jenkins WM, Merzenich MM. Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J Neurosci. 1996 ; 16: 785-807
5. Merzenich MM, Nelson RJ, Stryker MP, Cynader MS, Schoppmann A, Zook JM. Somatosensory cortical map changes following digit amputation in adult monkeys. J Comp Neurol. 1984 ; 224: 591-605
6. Pons TP, Garraghty PE, Ommaya AK, Kaas JH, Taub E, Mishkin M. Massive cortical reorganization after sensory deafferentation in adult macaques. Science. 1991 ; 252: 1857-1860
7. Kaas JH, Qi HX. The reorganization of the motor system in primates after the loss of a limb. Restor Neurol Neurosci. 2004 ; 22: 145-152
8. Wu CW, Kaas JH. Reorganization in primary motor cortex of primates with long-standing therapeutic amputations. J Neurosci. 1999 ; 19: 7679-7697
9. Florence SL, Kaas JH. Large-scale reorganization at multiple levels of the somatosensory pathway follows therapeutic amputation of the hand in monkeys. J Neurosci. 1995 ; 15: 8083-8095
10. Qi HX, Stepniewska I, Kaas JH. Reorganization of primary motor cortex in adult macaque monkeys with long-standing amputations. J Neurophysiol. 2000 ; 84: 2133-2147
11. Kew JJ, Halligan PW, Marshall JC, et al. Abnormal access of axial vibrotactile input to deafferented somatosensory cortex in human upper limb amputees. J Neurophysiol. 1997 ; 77: 2753-2764
12. Yang TT, Gallen CC, Ramachandran VS, Cobb S, Schwartz BJ, Bloom FE. Noninvasive detection of cerebral plasticity in adult human somatosensory cortex. Neuroreport. 1994 ; 5: 701-704
13. Kew JJ, Ridding MC, Rothwell JC, et al. Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation. J Neurophysiol. 1994 ; 72: 2517-2524
14. Karl A, Birbaumer N, Lutzenberger W, Cohen LG, Flor H. Reorganization of motor and somatosensory cortex in upper extremity amputees with phantom limb pain. J Neurosci. 2001 ; 21: 3609-3618
15. Gagne M, Hetu S, Reilly KT, Mercier C. The map is not the territory: motor system reorganization in upper limb amputees. Hum Brain Mapp. 2011 ; 32: 509-519
16. Elbert T, Sterr A, Flor H, et al. Input-increase and input-decrease types of cortical reorganization after upper extremity amputation in humans. Exp Brain Res. 1997 ; 117: 161-164
17. Cramer SC, Finklestein SP, Schaechter JD, Bush G, Rosen BR. Activation of distinct motor cortex regions during ipsilateral and contralateral finger movements. J Neurophysiol. 1999 ; 81: 383-387
18. Cruz VT, Nunes B, Reis AM, Pereira JR. Cortical remapping in amputees and dysmelic patients: a functional MRI study. NeuroRehabilitation. 2003 ; 18: 299-305
19. MacIver K, Lloyd DM, Kelly S, Roberts N, Nurmikko T. Phantom limb pain, cortical reorganization and the therapeutic effect of mental imagery. Brain. 2008 ; 131 (pt 8). 2181-2191
20. Werhahn KJ, Mortensen J, Kaelin-Lang A, Boroojerdi B, Cohen LG. Cortical excitability changes induced by deafferentation of the contralateral hemisphere. Brain. 2002 ; 125 (pt 6). 1402-1413
21. Frey SH, Bogdanov S, Smith JC, Watrous S, Breidenbach WC. Chronically deafferented sensory cortex recovers a grossly typical organization after allogenic hand transplantation. Curr Biol. 2008 ; 18: 1530-1534
22. Reilly KT, Sirigu A. The motor cortex and its role in phantom limb phenomena. Neuroscientist. 2008 ; 14: 195-202
23. Dhillon GS, Kruger TB, Sandhu JS, Horch KW. Effects of short-term training on sensory and motor function in severed nerves of long-term human amputees. J Neurophysiol. 2005 ; 93: 2625-2633
24. Dhillon GS, Lawrence SM, Hutchinson DT, Horch KW. Residual function in peripheral nerve stumps of amputees: implications for neural control of artificial limbs. J Hand Surg Am. 2004 ; 29: 605-615
25. Reilly KT, Mercier C, Schieber MH, Sirigu A. Persistent hand motor commands in the amputees' brain. Brain. 2006 ; 129: 2211-2223
26. Cohen LG, Bandinelli S, Findley TW, Hallett M. Motor reorganization after upper limb amputation in man: a study with focal magnetic stimulation. Brain. 1991 ; 114: 615-627
27. Malouin F, Richards CL, Durand A, et al. Effects of practice, visual loss, limb amputation, and disuse on imagery vividness. Neurorehabil Neural Repair. 2009 ; 23: 449-463
28. Mercier C, Reilly KT, Vargas CD, Aballea A, Sirigu A. Mapping phantom movement representations in the motor cortex of amputees. Brain. 2006 ; 129: 2202-2210
29. Pascual-Leone A, Peris M, Tormos JM, Pascual AP, Catala MD. Reorganization of human cortical motor output maps following amputee forearm amputation. Neuroreport. 1996 ; 7: 2068-2070
30. Lotze M, Halsband U. Motor imagery. J Physiol. 2006 ; 99: 386-395
31. Mercier C, Sirigu A. Training with virtual visual feedback to alleviate phantom limb pain. Neurorehabil Neural Repair. 2009 ; 23: 587-594
32. Roux FE, Ibarrola D, Lazorthes Y, Berry I. Virtual movements activate primary sensorimotor areas in amputees: report of three cases. Neurosurgery. 2001 ; 49: 736-741
33. Ramachandran VS, Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc Biol Sci. 1996 ; 263: 377-386
34. Diers M, Christmann C, Koeppe C, Ruf M, Flor H. Mirrored, imagined and executed movements differentially activate sensorimotor cortex in amputees with and without phantom limb pain. Pain. 2010 ; 149: 296-304
35. Chan BL, Witt R, Charrow AP, et al. Mirror therapy for phantom limb pain. N Engl J Med. 2007 ; 357: 2206-2207
36. Cacchio A, De Blasis E, De Blasis V, Santilli V, Spacca G. Mirror therapy in complex regional pain syndrome type 1 of the upper limb in stroke patients. Neurorehabil Neural Repair. 2009 ; 23: 792-799
37. Dohle C, Pullen J, Nakaten A, Kust J, Rietz C, Karbe H. Mirror therapy promotes recovery from severe hemiparesis: a randomized controlled trial. Neurorehabil Neural Repair. 2009 ; 23: 209-217
38. Sathian K, Greenspan AI, Wolf SL. Doing it with mirrors: a case study of a novel approach to neurorehabilitation. Neurorehabil Neural Repair. 2000 ; 14: 73-76
39. Stevens JA, Stoykov ME. Using motor imagery in the rehabilitation of hemiparesis. Arch Phys Med Rehabil. 2003 ; 84: 1090-1092
40. Rosen B, Lundborg G. Training with a mirror in rehabilitation of the hand. Scand J Plast Reconstr Surg Hand Surg. 2005 ; 39: 104-108
41. Shinoura N, Suzuki Y, Watanabe Y, et al. Mirror therapy activates outside of cerebellum and ipsilateral M1. NeuroRehabilitation. 2008 ; 23: 245-252
42. Moseley GL, Gallace A, Spence C. Is mirror therapy all it is cracked up to be? Current evidence and future directions. Pain. 2008 ; 138: 7-10
43. Smith SM, Jenkinson M, Woolrich MW, et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004 ; 23 (suppl 1). S208 - S219
44. AnderssonJLRJenkinsonMSmithSM. Non-linear optimisation. 2007. FMRIB technical report TR07JA1available at www.fmrib.ox.ac.uk/analysis/techrep
45. Beckmann CF, Jenkinson M, Smith SM. General multilevel linear modeling for group analysis in FMRI. Neuroimage. 2003 ; 20: 1052-1063
46. Woolrich MW, Behrens TEJ, Beckmann CF, Jenkinson M, Smith SM. Multi-level linear modelling for FMRI group analysis using Bayesian inference. Neuroimage. 2004 ; 21: 1732-1747
47. Van Essen DC. A population-average, landmark- and surface-based (PALS) atlas of human cerebral cortex. Neuroimage. 2005 ; 28: 635-662
48. Poldrack R. Region of interest analysis for fMRI. Soc Cogn Affect Neurosci. 2006 ; 2: 67-70
49. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971 ; 9: 97-113
50. Matthys K, Smits M, Van der Geest JN, et al. Mirror-induced visual illusion of hand movements: a functional magnetic resonance imaging study. Arch Phys Med Rehabil. 2009 ; 90: 675-681
51. Dettmers C, Adler T, Rzanny R, et al. Increased excitability in the primary motor cortex and supplementary motor area in patients with phantom limb pain after upper limb amputation. Neurosci Lett. 2001 ; 307: 109-112
52. Hamzei F, Liepert J, Dettmers C, et al. Structural and functional cortical abnormalities after upper limb amputation during childhood. Neuroreport. 2001 ; 12: 957-962
53. Perez MA, Cohen LG. Interhemispheric inhibition between primary motor cortices: what have we learned?. J Physiol. 2009 ; 587 (pt 4). 725-726
54. Ferbert A, Priori A, Rothwell JC, Day BL, Colebatch JG, Marsden CD. Interhemispheric inhibition of the human motor cortex. J Physiol. 1992 ; 453: 525-546
55. Ziemann U, Corwell B, Cohen LG. Modulation of plasticity in human motor cortex after forearm ischemic nerve block. J Neurosci. 1998 ; 18: 1115-1123
56. Philip BA, Frey SH. Preserved grip selection planning in chronic unilateral upper extremity amputees. Exp Brain Res. 2011 ; 214: 437-452
57. Eickhoff SB, Stephan KE, Mohlberg H, et al. A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. Neuroimage. 2005 ; 25: 1325-1335
58. Brodie EE, Whyte A, Niven CA. Analgesia through the looking-glass? A randomized controlled trial investigating the effect of viewing a "virtual" limb upon phantom limb pain, sensation and movement. Eur J Pain. 2007 ; 11: 428-436