Neuropsychiatric complications of aging with HIV

Journal of NeuroVirology

Volumn 18, Issue 4, 2012, Pages 277-290

  Watkins, Crystal C ^a   Treisman, Glenn J ^a,b  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Depression; Human immunodeficiency virus (HIV)

Indexed keywords

ADJUSTMENT DISORDER; AGING; BIPOLAR DISORDER; CD4 LYMPHOCYTE COUNT; COGNITIVE DEFECT; COMORBIDITY; DELIRIUM; DEPRESSION; DYSLIPIDEMIA; ENDOCRINE DISEASE; GENERALIZED ANXIETY DISORDER; HIGH RISK PATIENT; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LACTIC ACIDOSIS; LIVER TOXICITY; MAJOR DEPRESSION; MANIA; MENTAL DISEASE; METABOLIC SYNDROME X; MORTALITY; NEUROPSYCHIATRY; PANCREAS DISEASE; PATIENT COMPLIANCE; PATIENT EDUCATION; PERIPHERAL NEUROPATHY; PERSONALITY DISORDER; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SCHIZOPHRENIA; SUBSTANCE ABUSE; SURVIVAL; VIRUS LOAD; VIRUS REPLICATION;

AGING; AIDS DEMENTIA COMPLEX; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COGNITION DISORDERS; COMORBIDITY; HUMANS; LIFE EXPECTANCY; PREVALENCE; PSYCHOTIC DISORDERS; RISK FACTORS; SUBSTANCE-RELATED DISORDERS; UNITED STATES;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84863653035     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-012-0108-z     Document Type: Review

References (111)

1. Alciati A, Starace F, Scaramelli B, Campaniello M, Adriani B, Mellado C, Cargnel A (2001) Has there been a decrease in the prevalence of mood disorders in HIV-seropositive individuals since the introduction of combination therapy? Eur Psychiatry 16:491-496
2. Alciati A, Gallo L, Monforte AD, Brambilla F, Mellado C (2007) Major depression-related immunological changes and combination antiretroviral therapy in HIV-seropositive patients. Hum Psy-chopharmacol 22:33-40
3. Angelino AF, Treisman GJ (2008) Issues in co-morbid severe mental illnesses in HIV infected individuals. Int Rev Psychiatry 20:95-101
4. Azar MM, Springer SA, Meyer JP, Altice FL (2010) A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Drug Alcohol Depend 112:178-93
5. Becker JT, Lopez OL, Dew MA, Aizenstein HJ (2004) Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS 18(Suppl 1):S11-S18
6. Bing EG, Burnam MA, Longshore D, Fleishman JA, Sherbourne CD, London AS, Turner BJ, Eggan F, Beckman R, Vitiello B, Morton SC, Orlando M, Bozzette SA, Ortiz-Barron L, Shapiro M (2001) Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiatry 58:721-728
7. Butt AA, Dascomb KK, DeSalvo KB, Bazzano L, Kissinger PJ, Szerlip HM (2001) Human immunodeficiency virus infection in elderly patients. South Med J 94:397-400
8. Campos LN, Guimaraes MD, Remien RH (2008) Anxiety and depression symptoms as risk factors for non-adherence to antiretroviral therapy in Brazil. AIDS Behav 14:289-299
9. Carrico AW, Antoni MH, Duran RE, Ironson G, Penedo F, Fletcher MA, Klimas N, Schneiderman N (2006) Reductions in depressed mood and denial coping during cognitive behavioral stress management with HIV-Positive gay men treated with HAART. Ann Behav Med 31:155-164
10. Cherner M, Ellis RJ, Lazzaretto D, Young C, Mindt MR, Atkinson JH, Grant I, Heaton RK (2004) Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings. AIDS 18 (Suppl 1):S27-S34
11. Cole MA, Margolick JB, Cox C, Li X, Selnes OA, Martin EM, Becker JT, Aronow HA, Cohen B, Sacktor N, Miller EN (2007) Longitudinally preserved psychomotor performance in long-term asymptomatic HIV-infected individuals. Neurology 69:2213-2220
12. Centers for Disease Control and Prevention (2008) HIV/AIDS among persons age 50 and older. At: http://www.cdc.gov/hiv/az.htm
13. Cooperman NA, Simoni JM (2005) Suicidal ideation and attempted suicide among women living with HIV/AIDS. J Behav Med 28:149-156
14. Deeks SG (2010) HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med 62:141-155
15. DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW (2002) Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 40:794-811
16. DiMatteo MR, Lepper HS, Croghan TW (2000) Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med 160:2101-2107
17. Dolder CR, Patterson TL, Jeste DV (2004) HIV, psychosis and aging: past, present and future. AIDS 18(Suppl 1):S35-S42
18. Effros RB, Fletcher CV, Gebo K, Halter JB, Hazzard WR, Horne FM, Huebner RE, Janoff EN, Justice AC, Kuritzkes D, Nayfield SG, Plaeger SF, Schmader KE, Ashworth JR, Campanelli C, Clayton CP, Rada B, Woolard NF, High KP (2008) Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis 47:542-553
19. Eich-Höchli E, Niklowitz MW, Luthy R, Opravil M (1997) Are im-munological markers, social and personal resources, or a complaint-free state predictors of progression among HIV-infected patients? Acta Psychiatr Scand 95:476-484
20. Ellen SR, Judd FK, Mijch AM, Cockram A (1999) Secondary mania in patients with HIV infection. Aust N Z J Psychiatry 33:353-368
21. Elliott A (1998) Anxiety and HIV Infection. STEP Perspect 98:11-14
22. Ellis RJ, Badiee J, Vaida F, Letendre S, Heaton RK, Clifford D, Collier AC, Gelman B, McArthur J, Morgello S, McCutchan JA (2011) Grant I CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy. AIDS 25:1747-51
23. Ellis RJ, Rosario D, Clifford DB, McArthur JC, Simpson D, Alexander T, Gelman BB, Vaida F, Collier A, Marra CM, Ances B, Atkinson JH, Dworkin RH, Morgello S, Grant I (2010) Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study. Arch Neurol 67:552-558
24. Ettenhofer ML, Hinkin CH, Castellon SA, Durvasula R, Ullman J, Lam M, Myers H, Wright MJ, Foley J (2009) Aging, neuro-cognition, and medication adherence in HIV infection. Am J Geriatr Psychiatry 17:281-290
25. Goetz MB, Boscardin WJ, Wiley D, Alkasspooles S (2001) Decreased recovery of CD4 lymphocytes in older HIV-infected patients beginning highly active antiretroviral therapy. AIDS 15:1576-1579
26. Grabar S, Kousignian I, Sobel A, Le Bras P, Gasnault J, Enel P, Jung C, Mahamat A, Lang JM, Costagliola D (2004) Immunologic and clinical responses to highly active antiretroviral therapy over 50 years of age. Results from the French Hospital Database on HIV. AIDS 18:2029-2038
27. Grov C, Golub SA, Parsons JT, Brennan M, Karpiak SE (2010) Loneliness and HIV-related stigma explain depression among older HIV-positive adults. AIDS Care 22:630-9
28. Haller DL, Miles DR (2003) Suicidal ideation among psychiatric patients with HIV: psychiatric morbidity and quality of life. AIDS Behav 7:101-108
29. Harris MJ, Jeste DV, Gleghorn A, Sewell DD (1991) New-onset psychosis in HIV-infected patients. J Clin Psychiatry 52:369-376
30. Havlik RJ, Brennan M, Karpiak SE (2011) Comorbidities and depression in older adults with HIV. Sex Health 8:551-559
31. Hinkin CH, Castellon SA, Atkinson JH, Goodkin K (2001) Neuropsy-chiatric aspects of HIV infection among older adults. J Clin Epidemiol 54(Suppl):S44-S52
32. Hinkin CH, Hardy DJ, Mason KI, Castellon SA, Durvasula RS, Lam MN, Stefaniak M (2004) Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuse. AIDS 18(Suppl 1):S19-S25
33. Holmes J, House A (2000) Psychiatric illness predicts poor outcome after surgery for hip fracture: a prospective cohort study. Psychol Med 30:921-929
34. Hriso E, Kuhn T, Masdeu JC, Grundman M (1991) Extrapyramidal symptoms due to dopamine-blocking agents in patients with AIDS encephalopathy. Am J Psychiatry 148:1558-1561
35. Ickovics JR, Hamburger ME, Vlahov D, Schoenbaum EE, Schuman P, Boland RJ, Moore J (2001) Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study. JAMA 285:1466-1474
36. Ingersoll KS, Farrell-Carnahan L, Cohen-Filipic J, Heckman CJ, Ceperich SD, Hettema J, Marzani-Nissen G (2011) A pilot randomized clinical trial of two medication adherence and drug use interventions for HIV+ crack cocaine users. Drug Alcohol Depend 116:177-187
37. Ironson GH, O'Cleirigh C, Schneiderman N, Weiss A, Costa PT Jr (2008) Personality and HIV disease progression: role of NEO-PI-R openness, extraversion, and profiles of engagement. Psychosom Med 70:245-253
38. Jacobsberg L, Frances A, Perry S (1995) Axis II diagnoses among volunteers for HIV testing and counseling. Am J Psychiatry 152:1222-1224
39. Justice AC, McGinnis KA, Atkinson JH, Heaton RK, Young C, Sadek J, Madenwald T, Becker JT, Conigliaro J, Brown ST, Rimland D, Crystal S, Simberkoff M (2004) Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care: Veterans Aging Cohort Five-Site Study. AIDS 18(Suppl 1):S49-S59
40. Kalichman SC, Kelly JA, Johnson JR, Bulto M (1994) Factors associated with risk for HIV infection among chronic mentally ill adults. Am J Psychiatry 151:221-227
41. Kalichman SC, Heckman T, Kochman A, Sikkema K, Bergholte J (2005) Depression and thoughts of suicide among middle-aged and older persons living with HIV-AIDS. Psychiatr Serv 51:903-907
42. Kelly B, Raphael B, Judd F, Perdices M, Kernutt G, Burnett P, Dunne M, Burrows G (1998) Posttraumatic stress disorder in response to HIV infection. Gen Hosp Psychiatry 20(6):345-52
43. Kilbourne AM, Justice AC, Rabeneck L, Rodriguez-Barradas M, Weissman S (2001) General medical and psychiatric comorbidity among HIV-infected veterans in the post-HAART era. J Clin Epidemiol 54(Suppl 1):S22-S28
44. Klinkenberg WD, Sacks S (2004) HIV/AIDS Treatment Adherence, Health Outcomes and Cost Study Group. Mental disorders and drug abuse in persons living with HIV/AIDS. AIDS Care 16 (Suppl 1):S22-S42
45. Koenig LJ, Pals SL, Bush T, Pratt Palmore M, Stratford D, Ellerbrock TV (2008) Randomized controlled trial of an intervention to prevent adherence failure among HIV-infected patients initiating antiretroviral therapy. Health Psychol 27:159-169
46. Kopnisky KL, Stoff DM, Rausch DM (2004) Workshop report: the effects of psychological variables on the progression of HIV-1 disease. Brain Behav Immun 18:246-261
47. Krishnan KR, Delong M, Kraemer H, Carney R, Spiegel D, Gordon C, McDonald W, Dew M, Alexopoulos G, Buckwalter K, Cohen PD, Evans D, Kaufmann PG, Olin J, Otey E, Wainscott C (2002) Comorbidity of depression with other medical diseases in the elderly. Biol Psychiatry 52(6):559-88
48. Lenz G, Demal U (2000) Quality of life in depression and anxiety disorders: an exploratory follow-up study after intensive inpatient cognitive behaviour therapy. Psychopathology 33:297-302
49. Leserman J (2003) HIV disease progression: depression, stress, and possible mechanisms. Biol Psychiatry 54:295-306
50. Leserman J (2008) Role of depression, stress, and trauma in HIV disease progression. Psychosom Med 70:539-545
51. Letendre SL, Woods SP, Ellis RJ, Atkinson JH, Masliah E, van den Brande G, Durelle J, Grant I, Everall I (2006) Lithium improves HIV-associated neurocognitive impairment. AIDS 20:1885-1888
52. Lodwick R, Costagliola D, Reiss P, Torti C, Teira R, Dorrucci M, Ledergerber B, Mocroft A, Podzamczer D, Cozzi-Lepri A, Obel N, Masquelier B, Staszewski S, Garcia F, De Wit S, Castagna A, Antinori A, Judd A, Ghosn J, Touloumi G, Mussini C, Duval X, Ramos J, Meyer L, Warsawski J, Thorne C, Masip J, Perez-Hoyos S, Pillay D, van Sighem A, Lo Caputo S, Gunthard H, Paredes R, De Luca A, Paraskevis D, Fabre-Colin C, Kjaer J, Chene G, Lundgren JD, Phillips AN (2010) Triple-class virologic failure in HIV-infected patients undergoing antiretroviral therapy for up to 10 years. Arch Intern Med 170:410-419
53. Lyketsos CG, Hanson A, Fishman M, McHugh PR, Treisman GJ (1994) Screening for psychiatric morbidity in a medical outpatient clinic for HIV infection: the need for a psychiatric presence. Int J Psychiatry Med 24:103-113
54. Lyketsos CG, Hoover DR, Guccione M (1996a) Depression and survival among HIV-infected persons. JAMA 275:35-36
55. Lyketsos CG, Hoover DR, Guccione M, Dew MA, Wesch JE, Bing EG, Treisman GJ (1996b) Changes in depressive symptoms as AIDS develops. The Multicenter AIDS Cohort Study. Am J Psychiatry 153:1430-1437
56. Lyketsos CG, Hoover DR, Guccione M, Senterfitt W, Dew MA, Wesch J, VanRaden MJ, Treisman GJ, Morgenstern H (1993) Depressive symptoms as predictors of medical outcomes in HIV infection. Multicenter AIDS Cohort Study. JAMA 270:2563-2567
57. Lyketsos CG, Schwartz J, Fishman M, Treisman G (1997) AIDS mania. J Neuropsychiatry Clin Neurosci 9:277-279
58. Maes CA, Louis M (2003) Knowledge of AIDS, perceived risk of AIDS, and at-risk sexual behaviors among older adults. J Am Acad Nurse Pract 15(11):509-16
59. Malaspina L, Woods SP, Moore DJ, Depp C, Letendre SL, Jeste D, Grant I (2011) Successful cognitive aging in persons living with HIV infection. J Neurovirol 17:110-119
60. Martin CP, Fain MJ, Klotz SA (2008) The older HIV-positive adult: a critical review of the medical literature. Am J Med 121:1032-1037
61. Martinez A, Israelski D, Walker C, Koopman C (2002) Posttraumatic stress disorder in women attending human immunodeficiency virus outpatient clinics. AIDS Patient Care STDS 16:283-291
62. Marwick KF, Kaaya SF (2010) Prevalence of depression and anxiety disorders in HIV-positive outpatients in rural Tanzania. AIDS Care 22:415-419
63. McArthur JC, Brew BJ (2010) HIV-associated neurocognitive disorders: is there a hidden epidemic? AIDS 24:1367-1370
64. McArthur JC, Steiner J, Sacktor N, Nath A (2010) Human immunodeficiency virus-associated neurocognitive disorders: mind the gap. Ann Neurol 67:699-714
65. Mehta S, Moore RD, Graham NM (1997) Potential factors affecting adherence with HIV therapy. AIDS 11:1665-1670
66. Mellins CA, Havens JF, McDonnell C, Lichtenstein C, Uldall K, Chesney M, Santamaria EK, Bell J (2009) Adherence to antiretroviral medications and medical care in HIV-infected adults diagnosed with mental and substance abuse disorders. AIDS Care 21:168-177
67. Meltzer-Brody S, Davidson JR (2000) Completeness of response and quality of life in mood and anxiety disorders. Depress Anxiety 12 (Suppl 1):95-101
68. Morrison MF, Petitto JM, Have TT, Gettes DR, Chiappini MS, Weber AL, Brinker-Spence P, Bauer MR, Douglas SD, Evans DL (2002) Depressive and anxiety disorders in women with HIV infection. Am J Psychiatry 159:789-796
69. Nakimuli-Mpungu E, Musisi S, Mpungu SK, Katabira E (2009) Clinical presentation of bipolar mania in HIV-positive patients in Uganda. Psychosomatics 50:325-330
70. Montoya ID, Whitsett DD (2003) New frontiers and challenges in HIV research among older minority populations. J Acquir Immune Defic Syndr 33(Suppl 2):S218-S221
71. Nath A, Schiess N, Venkatesan A, Rumbaugh J, Sacktor N, McArthur J (2008) Evolution of HIV dementia with HIV infection. Int Rev Psychiatry 20:25-31
72. Nurutdinova D, Chrusciel T, Zeringue A, Scherrer JF, Al-Aly Z, McDonald JR, Overton ET (2012) Mental health disorders and the risk of AIDS-defining illness and death in HIV-infected veterans. AIDS 26:229-234
73. Nguyen N, Holodniy M (2008) HIV infection in the elderly. Clin Interv Aging 3:453-472
74. Ozawa T (1997) Genetic and functional changes in mitochondria associated with aging. Physiol Rev 77:425-464
75. Palmer NB, Salcedo J, Miller AL et al (2003) Psychiatric and social barriers to HIV medication adherence in a triply diagnosed meth-adone population. AIDS Patient Care STDS 17:635-644
76. Pappas MK, Halkitis PN (2011) Sexual risk taking and club drug use across three age cohorts of HIV-positive gay and bisexual men in New York City. AIDS Care 23:1410-6
77. Patterson K, Young C, Woods SP, Vigil O, Grant I, Atkinson JH (2006) Screening for major depression in persons with HIV infection: the concurrent predictive validity of the Profile of Mood States Depression-Dejection Scale. Int J Methods Psychiatr Res 15:75-82
78. Perkins DO, Davidson EJ, Leserman J et al (1993) Personality disorder in patients infected with HIV: a controlled study with implications for clinical care. Am J Psychiatry 150:309-315
79. Perretta P, Akiskal HS, Nisita C et al (1998) The high prevalence of bipolar II and associated cyclothymic and hyperthymic temperaments in HIV-patients. J Affect Disord 50:215-224
80. Perry EB, Berman RM, Sanacora G, Anand A, Lynch-Colonese K, Charney DS (2004) Pindolol augmentation in depressed patients resistant to selective serotonin reuptake inhibitors: a double-blind, randomized, controlled trial. J Clin Psychiatry 65:238-243
81. Plummer ML, Watson-Jones D, Lees S, Baisley K, Matari S, Changalucha J, Clayton T, Mugeye K, Tanton C, Weiss HA, Ross DA, Hayes RJ (2010) A qualitative study of participant adherence in a randomized controlled trial of herpes suppressive therapy for HIV prevention in Tanzania. AIDS Care 22:499-508
82. Rabkin JG, Wagner GJ, McElhiney MC, Rabkin R, Lin SH (2004a) Testosterone versus fluoxetine for depression and fatigue in HIV/AIDS: a placebo-controlled trial. J Clin Psychopharmacol 24:379-385
83. Rabkin JG, McElhiney MC, Ferrando SJ (2004b) Mood and substance use disorders in older adults with HIV/AIDS: methodological issues and preliminary evidence. AIDS 18(Suppl 1):S43-S48
84. Rabkin JG, Williams JB, Remien RH, Goetz R, Kertzner R, Gorman JM (1991) Depression, distress, lymphocyte subsets, and human immunodeficiency virus symptoms on two occasions in HIVpositive homosexual men. Arch Gen Psychiatry 48:111-119
85. Riley ED, Wu AW, Perry S, Clark RA, Moss AR, Crane J, Bangsberg DR (2003) Depression and drug use impact health status among marginally housed HIV-infected individuals. AIDS Patient Care STDS 17:401-406
86. Sacktor NC, Wong M, Nakasujja N, Skolasky RL, Selnes OA, Musisi S, Robertson K, McArthur JC, Ronald A, Katabira E (2005) The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 19:1367-1374
87. Schiepers OJ, Wichers MC, Maes M (2005) Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry 29:201-217, Epub 2005 Jan 25
88. Sewell DD (1996) Schizophrenia and HIV. Schizophr Bull 22(3):465-73
89. Siegel K, Brown-Bradley CJ, Lekas H-M (2004) Strategies for coping with fatigue among HIV-positive individuals fifty years and older. AIDS Patient Care STDS 18:275-288
90. Singh AN, Golledge H, Catalan J (1997) Treatment of HIV-related psychotic disorders with risperidone: a series of 21 cases. J Psychosom Res 42:489-493
91. Sledjeski EM, Delahanty DL, Bogart LM (2005) Incidence and impact of posttraumatic stress disorder and comorbid depression on adherence to HAART and CD4+ counts in people living with HIV. AIDS Patient Care STDS 19:728-736
92. Sullivan PS, Zapata A, Benbow N (2008) New U.S. HIV incidence numbers: heeding their message. Focus 23(4):5-7
93. Sullivan LE, Goulet JL, Justice AC, Fiellin DA (2011) Alcohol consumption and depressive symptoms over time: a longitudinal study of patients with and without HIV infection. Drug Alcohol Depend 117:158-163
94. Summers J, Zisook S, Sciolla AD, San Diego HIV Neurobehavioral Research Center (HNRC) Group et al (2004) Gender, AIDS, and bereavement: a comparison of women and men living with HIV. Death Stud 28:225-241
95. Trobst KK, Wiggins JS, Costa PT Jr et al (2000) Personality psychology and problem behaviors: HIV risk and the five-factor model. J Pers 68:1233-1252
96. Tsai AC, Weiser SD, Petersen ML, Ragland K, Kushel MB, Bangsberg DR (2010) A marginal structural model to estimate the causal effect of antidepressant medication treatment on viral suppression among homeless and marginally housed persons with HIV. Arch Gen Psychiatry 67:1282-1290
97. Uldall KK, Berghuis JP (1997) Delirium in AIDS patients: recognition and medication factors. AIDS Patient Care STDS 11:435-441
98. Uldall KK, Harris VL, Lalonde B (2000a) Outcomes associated with delirium in acutely hospitalized acquired immune deficiency syndrome patients. Compr Psychiatry 41:88-91
99. Uldall KK, Ryan R, Berghuis JP, Harris VL (2000b) Association between delirium and death in AIDS patients. AIDS Patient Care STDS 14:95-100
100. Valcour V, Paul R (2006) HIV infection and dementia in older adults. Clin Infect Dis 42:1449-1454
101. Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Holck P, Grove J, Sacktor N (2004) Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort. Neurology 63:822-827
102. van der Lee MJ, Blenke AA, Rongen GA, Verwey-van Wissen CP, Koopmans PP, Pharo C, Burger DM (2007) Interaction study of the combined use of paroxetine and fosamprenavir-ritonavir in healthy subjects. Antimicrob Agents Chemother 51:4098-4104
103. van Servellen G, Chang B, Garcia L, Lombardi E (2002) Individual and system level factors associated with treatment nonadherence in human immunodeficiency virus-infected men and women. AIDS Patient Care STDS 16:269-281
104. Vance DE, Ross JA, Moneyham L, Farr KF, Fordham P (2010) A model of cognitive decline and suicidal ideation in adults aging with HIV. J Neurosci Nurs 42:150-156
105. Walkup JT, Akincigil A, Amin S, Hoover D, Siegel M, Crystal S (2010) Prevalence of diagnosed HIV disease among medicaid beneficiaries with schizophrenia in U.S. metropolitan areas. J Nerv Ment Dis 198:682-686
106. Walkup J, Akincigil A, Hoover DR, Siegel MJ, Amin S, Crystal S (2011) Use of Medicaid data to explore community characteristics associated with HIV prevalence among beneficiaries with schizophrenia. Public Health Rep 126(Suppl 3):89-101
107. Lelutiu-Weinberger C, Pachankis JE, Golub SA, Walker JJ, Bamonte AJ, Parsons JT (2012) Age cohort differences in the effects of gay-related stigma, anxiety and identification with the gay community on sexual risk and substance use. AIDS Behav (in press)
108. Wutoh AK, Elekwachi O, Clarke-Tasker V, Daftary M, Powell NJ, Campusano G (2003) Assessment and predictors of antiretroviral adherence in older HIV-infected patients. J Acquir Immune Defic Syndr 33(Suppl 2):S106-S114
109. Zablotsky D, Kennedy M (2003) Risk factors and HIV transmission to midlife and older women: knowledge, options, and the initiation of safer sexual practices. J Acquir Immune Defic Syndr 33(Suppl 2):S122-S130
110. Zanjani F, Saboe K, Oslin D (2007) Age difference in rates of mental health/substance abuse and behavioral care in HIV-positive adults. AIDS Patient Care STDS 21:347-355
111. Zelnetz PD, Epstein ME (1998) HIV in elderly. AIDS Patient Care STDS 17:255-262