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Volumn 18, Issue 29, 2012, Pages 8978-8986

Asymmetric synthesis of pochonin e and F, revision of their proposed structure, and their conversion to potent Hsp90 inhibitors

(6) Karthikeyan, Ganesan a Zambaldo, Claudio a Barluenga, Sofia a Zoete, Vincent b Karplus, Martin c Winssinger, Nicolas a

a UNIVERSITÉ DE STRASBOURG (France)

b SWISS INSTITUTE OF BIOINFORMATICS (Switzerland)

c HARVARD UNIVERSITY (United States)

Author keywords

conformation analysis; Hsp90; inhibitors; lactones; pochonins

Indexed keywords

AFFINITY MEASUREMENT; ASYMMETRIC SYNTHESIS; CONFORMATION ANALYSIS; DRUG DISCOVERY; EPIMERS; HEAT SHOCK PROTEIN; HSP90; LACTONES; MODULAR SYNTHESIS; MOLECULAR DYNAMICS SIMULATIONS; NATURAL PRODUCTS; POCHONINS;

CORROSION INHIBITORS; STEREOCHEMISTRY;

MOLECULAR DYNAMICS;

HEAT SHOCK PROTEIN 90; MACROLIDE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; METABOLISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MACROLIDES; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863643467 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201200546 Document Type: Article

Times cited : (22)

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