Sex steroids and bone health in older Chinese men

Osteoporosis International

Volumn 23, Issue 5, 2012, Pages 1553-1562

  Woo, J ^a,c   Kwok, T ^a   Leung, J C S ^a   Ohlsson, C ^b   Vandenput, L ^b   Leung, P C ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Bone mineral density; Estradiol; Testosterone

Indexed keywords

ESTRADIOL; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

AGED; ARTICLE; BONE; BONE DENSITY; CAUCASIAN; CHINESE; ESTRADIOL BLOOD LEVEL; FEMUR NECK; FOLLOW UP; FRACTURE; HIP; HIP FRACTURE; HUMAN; HUMERUS FRACTURE; MAJOR CLINICAL STUDY; MALE; OSTEOLYSIS; PELVIS FRACTURE; PRIORITY JOURNAL; RADIUS FRACTURE; TESTOSTERONE BLOOD LEVEL;

AGED; ANTHROPOMETRY; BONE DENSITY; ESTRADIOL; FEMUR NECK; FOLLOW-UP STUDIES; GONADAL STEROID HORMONES; HIP JOINT; HONG KONG; HUMANS; MALE; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 84863632262     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-011-1552-y     Document Type: Article

References (41)

1. Laughlin GA, Barrett-Connor E, Bergstrom J (2008) Low serum testosterone and mortality in older men. J Clin Endocrinol Metab 93:68-75
2. Yeap BB (2009) Are declining testosterone levels a major risk factor for ill-health in aging men? Int J Impot Res 21:24-36
3. Szulc P, Munoz F, Claustrat B, Garnero P, Marchand F, Duboeuf F, Delmas PD (2001) Bioavailable estradiol may be an important determinant of osteoporosis in men: the MINOS study. J Clin Endocrinol Metab 86:192-199
4. Amin S, Zhang Y, Sawin CT, Evans SR, Hannan MT, Kiel DP, Wilson PW, Felson DT (2000) Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study. Ann Intern Med 133:951-963 (Pubitemid 32003511)
5. van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW (2000) Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85:3276-3282
6. Goderie-Plomp HW, van der Klift M, de Ronde W, Hofman A, de Jong FH, Pols HA (2004) Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study. J Clin Endocrinol Metab 89:3261-3269 (Pubitemid 38951891)
7. Bjørnerem A, Ahmed LA, Joakimsen RM, Berntsen GK, Fonnebo V, Jorgensen L, Oian P, Seeman E, Straume B (2007) A prospective study of sex steroids, sex hormone-binding globulin, and non-vertebral fractures in women and men: the Tromso Study. Eur J Endocrinol 157:119-125 (Pubitemid 47162575)
8. Meier C, Nguyen TV, Handelsman DJ, Schindler C, Kushnir MM, Rockwood AL, Meikle AW, Center JR, Eisman JA, Seibel MJ (2008) Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology Study. Arch Intern Med 168:47-54
9. Araujo AB, Travison TG, Leder BZ, McKinlay JB (2008) Correlations between serum testosterone, estradiol, and sex hormone-binding globulin and bone mineral density in a diverse sample of men. J Clin Endocrinol Metab 93:2135-2141 (Pubitemid 351831527)
10. Vandenput L, Ohlsson C (2009) Estrogens as regulators of bone health in men. Nat Rev Endocrinol 5:437-443
11. Khosla S, Melton LJ 3rd, Atkinson EJ, O'Fallon WM (2001) Relationship of serum sex steroid levels to longitudinal changes inbone density in young versus elderly men. J Clin Endocrinol Metab 86:3555-3561 (Pubitemid 32755943)
12. Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston CC (1997) Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 100:1755-1759 (Pubitemid 27431332)
13. Ongphiphadhanakul B, Rajatanavin R, Chanprasertyothin S, Piaseu N, Chailurkit L (1998) Serum oestradiol and oestrogen-receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males. Clin Endocrinol (Oxf) 49:803-809 (Pubitemid 29009511)
14. Center JR, Nguyen TV, Sambrook PN, Eisman JA (1999) Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab 84:3626-3635 (Pubitemid 30645216)
15. Van Pottelbergh I, Goemaere S, Kaufman JM (2003) Bioavailable estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age. J Clin Endocrinol Metab 88:3075-3081 (Pubitemid 36877475)
16. Gennari L, Merlotti D, Martini G, Gonnelli S, Franci B, Campagna S, Lucani B, Dal Canto N, Valenti R, Gennari C, Nuti R (2003) Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men. J Clin Endocrinol Metab 88:5327-5333 (Pubitemid 37452735)
17. Cauley JA, Ewing SK, Taylor BC, Fink HA, Ensrud KE, Bauer DC, Barrett-Connor E, Marshall L, Orwoll ES (2010) Sex steroid hormones in older men: longitudinal associations with 4.5-year change in hip bone mineral density-the osteoporotic fractures in men study. J Clin Endocrinol Metab 95:4314-4323
18. Greendale GA, Edelstein S, Barrett-Connor E (1997) Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study. J Bone Miner Res 12:1833-1843 (Pubitemid 27500195)
19. Khosla S, Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL (1998) Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266-2274 (Pubitemid 28503012)
20. Mellstrom D, Johnell O, Ljunggren O, Eriksson AL, Lorentzon M, Mallmin H, Holmberg A, Redlund-Johnell I, Orwoll E, Ohlsson C (2006) Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden. J Bone Miner Res 21:529-535
21. Mellstrom D, Vandenput L, Mallmin H, Holmberg AH, Lorentzon M, Oden A, Johansson H, Orwoll ES, Labrie F, Karlsson MK, Ljunggren O, Ohlsson C (2008) Older men with low serum estradiol and high serum SHBG have an increased risk of fractures. J Bone Miner Res 23:1552-1560
22. LeBlanc ES, NielsonCM, Marshall LM, Lapidus JA, Barrett-Connor E, Ensrud KE, Hoffman AR, Laughlin G, Ohlsson C, Orwoll ES (2009) The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. J Clin Endocrinol Metab 94:3337-3346
23. Amin S, Zhang Y, Felson DT, Sawin CT, Hannan MT, Wilson PW, Kiel DP (2006) Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study. Am J Med 119:426-433
24. Litman HJ, Bhasin S, Link CL, Araujo AB, McKinlay JB (2006) Serum androgen levels in black, Hispanic, and white men. J Clin Endocrinol Metab 91:4326-4334 (Pubitemid 44833406)
25. Santner SJ, Albertson B, Zhang GY, Zhang GH, Santulli M, Wang C, Demers LM, Shackleton C, Santen RJ (1998) Comparative rates of androgen production and metabolism in Caucasian and Chinese subjects. J Clin Endocrinol Metab 83:2104-2109 (Pubitemid 28496344)
26. Lau EM, Lynn H,Woo J, Melton LJ 3rd (2003) Areal and volumetric bone density in Hong Kong Chinese: a comparison with Caucasians living in the United States. Osteoporos Int 14:583-588 (Pubitemid 36975558)
27. Cauley JA, Fullman RL, Stone KL, Zmuda JM, Bauer DC, Barrett-Connor E, Ensrud K, Lau EM, Orwoll ES (2005) Factors associated with the lumbar spine and proximal femur bone mineral density in older men. Osteoporos Int 16:1525-1537 (Pubitemid 41790856)
28. Jacobsen SJ, Goldberg J, Miles TP, Brody JA, Stiers W, Rimm AA (1990) Hip fracture incidence among the old and very old: a population-based study of 745,435 cases. Am J Public Health 80:871-873 (Pubitemid 20202209)
29. Baron JA, Barrett J, Malenka D, Fisher E, Kniffin W, Bubolz T, Tosteson T (1994) Racial differences in fracture risk. Epidemiology 5:42-47 (Pubitemid 24021114)
30. Lau EM (2001) Epidemiology of osteoporosis. Best Pract Res Clin Rheumatol 15:335-344 (Pubitemid 32755087)
31. Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K (2005) Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study-a large observational study of the determinants of fracture in older men. Contemp Clin Trials 26:569-585 (Pubitemid 41242402)
32. Lau EM, Leung PC, Kwok T, Woo J, Lynn H, Orwoll E, Cummings S, Cauley J (2006) The determinants of bone mineral density in Chinese men-results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men. Osteoporos Int 17:297-303 (Pubitemid 43053595)
33. Woo J, Leung SSF, Ho SC, Lam TH, Janus ED (1997) A food frequency questionnaire for use in the Chinese population in Hong Kong: description and examination of validity. Nutr Res 17:1633-1641 (Pubitemid 27459447)
34. Washburn RA, Smith KW, Jette AM, Janney CA (1993) The physical activity scale for the elderly (PASE): development and evaluation. J Clin Epidemiol 46:153-162 (Pubitemid 23092124)
35. Labrie F, Belanger A, Belanger P, Berube R, Martel C, Cusan L, Gomez J, Candas B, Castiel I, Chaussade V, Deloche C, Leclaire J (2006) Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women. J Steroid Biochem Mol Biol 99:182-188 (Pubitemid 43766081)
36. Vandenput L, Labrie F, Mellstrom D, Swanson C, Knutsson T, Peeker R, Ljunggren O, Orwoll E, Eriksson AL, Damber JE, Ohlsson C (2007) Serum levels of specific glucuronidated androgen metabolites predict BMD and prostate volume in elderly men. J Bone Miner Res 22:220-227 (Pubitemid 46167792)
37. Vermeulen A, Verdonck L, Kaufman JM (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672 (Pubitemid 30645223)
38. Ohlsson C, Vandenput L (2009) The role of estrogens for male bone health. Eur J Endocrinol 160:883-889
39. Orwoll E, Lambert LC, Marshall LM, Phipps K, Blank J, Barrett-Connor E, Cauley J, Ensrud K, Cummings S (2006) Testosterone and estradiol among older men. J Clin Endocrinol Metab 91:1336-1344
40. Orwoll ES, Nielson CM, Labrie F, Barrett-Connor E, Cauley JA, Cummings SR, Ensrud K, Karlsson M, Lau E, Leung PC, Lunggren O, Mellstrom D, Patrick AL, Stefanick ML, Nakamura K, Yoshimura N, Zmuda J, Vandenput L, Ohlsson C (2010) Evidence for geographical and racial variation in serum sex steroid levels in older men. J Clin Endocrinol Metab 95:E151-E160
41. Borst SE (2004) Interventions for sarcopenia and muscle weakness in older people. Age Ageing 33:548-555 (Pubitemid 39504285)