Nutrient interaction for optimal protein anabolism in resistance exercise

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 15, Issue 3, 2012, Pages 226-232

  Breen, Leigh ^a   Phillips, Stuart M ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Cachexia; Hypertrophy; Protein metabolism; Skeletal muscle

Indexed keywords

AMINO ACID; INSULIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MUSCLE PROTEIN; PROTEIN;

CACHEXIA; CANCER PATIENT; DIET SUPPLEMENTATION; DIET THERAPY; HUMAN; HYPERINSULINEMIA; MUSCLE ATROPHY; MUSCLE HYPERTROPHY; MUSCLE METABOLISM; PROTEIN INDUCTION; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RESISTANCE TRAINING; REVIEW; RNA TRANSLATION; SKELETAL MUSCLE; TRANSLATION INITIATION; WEIGHT LIFTING;

CACHEXIA; DIETARY PROTEINS; HUMANS; HYPERTROPHY; LEUCINE; MUSCLE PROTEINS; MUSCULAR ATROPHY; PROTEIN BIOSYNTHESIS; RESISTANCE TRAINING;

EID: 84863630186     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3283516850     Document Type: Review

References (28)

1. Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011;12:489-495.
2. English KL, Paddon-Jones D. Protecting muscle mass and function in older adults during bed rest. Curr Opin Clin Nutr Metab Care 2010;13:34-39.
3. Evans WJ, Morley JE, Argiles J, et al. Cachexia: a new definition. Clin Nutr 2008;27:793-799.
4. Burd NA, West DW, Rerecich T, et al. Validation of a single biopsy approach and bolus protein feeding to determine myofibrillar protein synthesis in stable isotope tracer studies in humans. Nutr Metab 2011;8:15.
5. Atherton PJ, Etheridge T, Watt PW, et al. Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. Am J Clin Nutr 2010;92:1080-1088. Demonstration of the relationship between the rise in MPS and anabolic signalling with protein feeding.
6. Bohe J, Low JF, Wolfe RR, et al. Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids. J Physiol 2001;532(Pt 2):575-579.
7. Phillips SM, Tipton KD, Aarsland A, et al. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol 1997;273(Pt 1):E99-E107.
8. Phillips SM, Tipton KD, Ferrando AA, et al. Resistance training reduces the acute exercise-induced increase in muscle protein turnover. Am J Physiol 1999;276(Pt 1):E118-E124.
9. Hartman JW, Tang JE, Wilkinson SB, et al. Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters. Am J Clin Nutr 2007;86:373-381.
10. Kumar V, Selby A, Rankin D, et al. Age-related differences in the doseresponse relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol 2009;587(Pt 1):211-217.
11. Breen L, Phillips SM. Skeletal muscle protein metabolism in the elderly: interventions to counteract the 'anabolic resistance' of ageing. Nutr Metab 2011;8:68.
12. Fry CS, Drummond MJ, Glynn EL, et al. Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis. Skeletal Muscle 2011;1:11.
13. Biolo G, Antonione R, Barazzoni R, et al. Mechanisms of altered protein turnover in chronic diseases: a review of human kinetic studies. Curr Opin Clin Nutr Metab Care 2003;6:55-63.
14. Kadar L, Albertsson M, Areberg J, et al. The prognostic value of body protein in patients with lung cancer. Ann N Y Acad Sci 2000;904:584-591.
15. White JP, Baynes JW, Welle SL, et al. The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the apc mouse. PLoS One 2011;6:e24650.
16. Khal J, Hine AV, Fearon KC, et al. Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss. Int J Bio Cell Biol 2005;37:2196-2206.
17. Bodine SC, Latres E, Baumhueter S, et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 2001;294:1704-1708.
18. Toth MJ, LeWinter MM, Ades PA, et al. Impaired muscle protein anabolic response to insulin and amino acids in heart failure patients: relationship with markers of immune activation. Clin Sci 2010;119:467-476. Cachexic muscles are unresponsive to nutrient provision.
19. Tuvdendorj D, Chinkes DL, Zhang XJ, et al. Skeletal muscle is anabolically unresponsive to an amino acid infusion in pediatric burn patients 6 months postinjury. Ann Surg 2011;253:592-597. Cachexic muscles are unresponsive to amino acid provision.
20. Deutz NE, Safar A, Schutzler S, et al. Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food. Clin Nutr 2011;30:759-768. The 'resistance' of cachexic muscles to protein feeding can be abolished when additional leucine-rich protein is ingested.
21. Burd NA, West DW, Staples AW, et al. Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men. PLoS One 2010;5:e12033. Resistance exercise performed with a low load to failure can stimulate rates of MPS equivalent to traditional high-load exercise.
22. Burd NA, Holwerda AM, Selby KC, et al. Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men. J Physiol 2010;588:3119-3130.
23. Wilkinson SB, Tarnopolsky MA, Macdonald MJ, et al. Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage. Am J Clin Nutr 2007;85:1031-1040.
24. Camera DM, Edge J, Short MJ, et al. Early time course of Akt phosphorylation after endurance and resistance exercise. Med Sci Sports Exerc 2010;42:1843-1852.
25. Apro W, Blomstrand E. Influence of supplementation with branched-chain amino acids in combination with resistance exercise on p70S6 kinase phosphorylation in resting and exercising human skeletal muscle. Acta physiologica 2010;200:237-248.
26. Durham WJ, Casperson SL, Dillon EL, et al. Age-related anabolic resistance after endurance-type exercise in healthy humans. FASEB J 2010;24:4117-4127.
27. Onambele-Pearson GL, Breen L, Stewart CE. Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations. Age 2010;32:139-153.
28. Toth MJ, Matthews DE, Tracy RP, et al. Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am J Physiol Endocrinol Metab 2005;288:E883-E891.