Risk of hypothyroidism following hemithyroidectomy: Systematic review and meta-analysis of prognostic studies

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 7, 2012, Pages 2243-2255

  Verloop, Herman ^a   Louwerens, Marloes ^a   Schoones, Jan W ^a   Kievit, Job ^a   Smit, Johannes W A ^a   Dekkers, Olaf M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

THYROID HORMONE; THYROTROPIN;

GRAVES DISEASE; HEMITHYROIDECTOMY; HUMAN; HYPOTHYROIDISM; INCIDENCE; LOGISTIC REGRESSION ANALYSIS; META ANALYSIS; NODULAR GOITER; ONCOCYTOMA; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK ASSESSMENT; RISK FACTOR; SYSTEMATIC REVIEW; THYROID FOLLICULAR CARCINOMA; THYROID FUNCTION; THYROID NODULE; THYROIDECTOMY;

ALGORITHMS; HUMANS; HYPOTHYROIDISM; INCIDENCE; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; RISK FACTORS; THYROIDECTOMY;

EID: 84863570586     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-1063     Document Type: Review

References (81)

1. Cooper DS, Doherty GM, Haugen BR, Hauger BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM 2009 Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19:1167-1214
2. Traugott AL, Dehdashti F, Trinkaus K, Cohen M, Fialkowski E, Quayle F, Hussain H, Davila R, Ylagan L, Moley JF 2010 Exclusion of malignancy in thyroid nodules with indeterminate fine-needle aspiration cytology after negative 18F-fluorodeoxyglucose positron emission tomography: interim analysis. World J Surg 34:1247-1253
3. Stoll SJ, Pitt SC, Liu J, Schaefer S, Sippel RS, Chen H 2009 Thyroid hormone replacement after thyroid lobectomy. Surgery 146:554-558; discussion 558-560
4. Biondi B, Fazio S, Cuocolo A, Sabatini D, Nicolai E, Lombardi G, Salvatore M, Saccà L 1996 Impaired cardiac reserve and exercise capacity in patients receiving long-term thyrotropin suppressive therapy with levothyroxine. J Clin Endocrinol Metab 81:4224-4228 (Pubitemid 26412021)
5. Heemstra KA, Hamdy NA, Romijn JA, Smit JW 2006 The effects of thyrotropin-suppressive therapy on bone metabolism in patients with well-differentiated thyroid carcinoma. Thyroid 16:583-591 (Pubitemid 44066265)
6. Sawin CT, Geller A, Wolf PA, Belanger AJ, Baker E, Bacharach P, Wilson PW, Benjamin EJ, D'Agostino RB 1994 Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med 331:1249-1252 (Pubitemid 24333188)
7. Schlote B, Nowotny B, Schaaf L, Kleinböhl D, Schmidt R, Teuber J, Paschke R, Vardarli I, Kaumeier S, Usadel KH 1992 Subclinical hyperthyroidism: physical and mental state of patients. Eur Arch Psychiatry Clin Neurosci 241:357-364
8. Saravanan P, Chau WF, Roberts N, Vedhara K, Greenwood R, Dayan CM 2002 Psychological well-being in patients on 'adequate'doses of l-thyroxine: results of a large, controlled community-based questionnaire study. Clin Endocrinol (Oxf) 57:577-585 (Pubitemid 35316973)
9. Biondi B, Cooper DS 2008 The clinical significance of subclinical thyroid dysfunction. Endocr Rev 29:76-131 (Pubitemid 351252748)
10. Berglund J, Aspelin P, Bondeson AG, Bondeson L, Christensen SB, Ekberg O, Nilsson P 1998 Rapid increase in volume of the remnant after hemithyroidectomy does not correlate with serum concentration of thyroid stimulating hormone. Eur J Surg 164:257-262 (Pubitemid 28215247)
11. Johner A, Griffith OL, Walker B, Wood L, Piper H, Wilkins G, Baliski C, Jones SJ, Wiseman SM 2011 Detection and management of hypothyroidism following thyroid lobectomy: evaluation of a clinical algorithm. Ann Surg Oncol 18:2548-2554
12. Hamza TH, van Houwelingen HC, Stijnen T 2008 The binomial distribution of meta-analysis was preferred to model within-study variability. J Clin Epidemiol 61:41-51 (Pubitemid 350236698)
13. DerSimonian R, Laird N 1986 Meta-analysis in clinical trials. Control Clin Trials 7:177-188 (Pubitemid 17189972)
14. Chang BH, Waternaux C, Lipsitz S 2001 Meta-analysis of binary data: which within study variance estimate to use? Stat Med 20: 1947-1956 (Pubitemid 32605722)
15. Sweeting MJ, Sutton AJ, Lambert PC 2004 What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Stat Med 23:1351-1375 (Pubitemid 38594143)
16. Berglund J, Bondesson L, Christensen SB, Larsson AS, Tibblin S 1990 Indications for thyroxine therapy after surgery for nontoxic benign goitre. Acta Chir Scand 156:433-438 (Pubitemid 20188403)
17. Heath V 2010 Thyroid gland: hypothyroidism found to be a frequent occurrence after partial thyroidectomy. Nat Rev Endocrinol 6:8
18. Di Matteo G, Lucci S, Marchegiani C 1984 Indications, procedures and results in the surgical treatment of hyperthyroidism: a follow-up of 336 cases. Ital J Surg Sci 14:211-216 (Pubitemid 14016104)
19. Eckert H, Green M, Kilpatrick R, Wilson GM 1960 Thyroid function after treatment of thyrotoxicosis by partial thyroidectomy or 131 iodine. Clin Sci 20:87-97
20. Roy AD, Allan J, Harden RM 1967 A follow-up of thyrotoxic patients treated by partial thyroidectomy. Lancet 2:684-688
21. Michie W, Pegg CA, Bewsher PD 1972 Prediction of hypothyroidism after partial thyroidectomy for thyrotoxicosis. Br Med J 1:13-17
22. Gough AL, Neill RW 1974 Partial thyroidectomy for thyrotoxicosis. Br J Surg 61:939-942
23. Kennedy JS, Thomson JA 1974 The changes in the thyroid gland after irradiation with 131I or partial thyroidectomy for thyrotoxicosis. J Pathol 112:65-81
24. Tweedle D, Colling A, Schardt W, Green EM, Evered DC, Dickinson PH, Johnston ID 1977 Hypothyroidism following partial thyroidectomy for thyrotoxicosis and its relationship to thyroid remnant size. Br J Surg 64:445-448 (Pubitemid 8121840)
25. Andåker L, Johansson K, Smeds S, Lennquist S 1992 Surgery for hyperthyroidism: hemithyroidectomy plus contralateral resection or bilateral resection? A prospective randomized study of postoperative complications and long-term results. World J Surg 16:765-769
26. Griffiths NJ, Murley RS, Gulin R, Simpson RD, Woods TF, Burnett D1974 Thyroid function following partial thyroidectomy. Br J Surg 61:626-632
27. Keogh JC, Grace PA, Brown HJ, Browne HJ 1977 Hypothyroidism following partial thyroidectomy. Ir Med J 70:261-262 (Pubitemid 8125972)
28. Wahl RA, Hufner M, Joseph K, Roher HD 1983 Function of remaining thyroid tissue after operations for smooth and autonomic nodular goiters. [German] Therapiewoche 33:3915-3922 (Pubitemid 13076559)
29. Bennedbaek FN, Perrild H, Hegedüs L 1999 Diagnosis and treatment of the solitary thyroid nodule. Results of a European survey. Clin Endocrinol (Oxf) 50:357-363 (Pubitemid 29166716)
30. Campion L, Gallou G, Ruelland A, Cloarec L, Allannic H 1995 Lipid and thyroid changes after partial thyroidectomy: guidelines for Lthyroxine therapy? Clin Chem 41:473-474
31. Lehwald N, Cupisti K, Willenberg HS, Schott M, Krausch M, Raffel A, Wolf A, Brinkmann K, Eisenberger CF, Knoefel WT 2009 Standard-radical vs. function-preserving surgery of benign nodular goiter: a sonographic and biochemical 10-year follow-up study. Langenbecks Arch Surg 394:279-283
32. Marchesi M, Biffoni M, Faloci C, Biancari F, Campana FP 2002 High rate of recurrence after lobectomy for solitary thyroid nodule. Eur J Surg 168:397-400 (Pubitemid 35347016)
33. Rodier JF, Strasser C, Janser JC, Navarrete E, Pusel J, Methlin G, Rodier D 1990 [Thyroid function after thyroidectomy for benign goiter. 200 cases explored by ultrasensitive TSH]. J Chir (Paris) 127:445-451
34. Bellantone R, Lombardi CP, Boscherini M, Raffaelli M, Tondolo V, Alesina PF, Corsello SM, Fintini D, Bossola M 2004 Predictive factors for recurrence after thyroid lobectomy for unilateral non-toxic goiter in an endemic area: results of a multivariate analysis. Surgery 136:1247-1251 (Pubitemid 39647541)
35. Rosato L, Avenia N, Bernante P, De Palma M, Gulino G, Nasi PG, Pelizzo MR, Pezzullo L 2004 Complications of thyroid surgery: analysis of a multicentric study on 14,934 patients operated on in Italy over 5 years. World J Surg 28:271-276 (Pubitemid 38375527)
36. Asari R, Niederle BE, Scheuba C, Riss P, Koperek O, Kaserer K, Niederle B 2010 Indeterminate thyroid nodules: a challenge for the surgical strategy. Surgery 148:516-525
37. Niepomniszcze H, Garcia A, Faure E, Castellanos A, del Carmen Zalazar M, Bur G, Elsner B 2001 Long-term follow-up of contralateral lobe in patients hemithyroidectomized for solitary follicular adenoma. Clin Endocrinol (Oxf) 55:509-513 (Pubitemid 32955489)
38. Korun N, Åci C, Yilmazlar T, Duman H, Zorluoglu A, Tuncel E, Ertürk E, Yerci O 1997 Total thyroidectomy or lobectomy in benign nodular disease of the thyroid: changing trends in surgery. Int Surg 82:417-419 (Pubitemid 27500951)
39. Bourguignat E, Barrault S, Mayaux MJ, Koubbi G, Fombeur JP 1995 [Conditions of the remaining thyroid tissue after partial thyroidectomy]. Ann Otolaryngol Chir Cervicofac 112:330-335
40. Heberling HJ, Heintze M, Kuhlmann E, Lohmann D, Hartig W, Mättig H 1984 [The thyrotropic function of the hypophysis and peripheral thyroid hormones after removal of bland and autonomous nodular goiters]. Dtsch Med Wochenschr 109:1757-1760
41. Matte R, Ste-Marie LG, Comtois R, D'Amour P, Lacroix A, Chartrand R, Poisson R, Bastomsky CH 1981 The pituitary-thyroid axis after hemithyroidectomy in euthyroid man. J Clin Endocrinol Metab 53:377-380 (Pubitemid 13250298)
42. Gemsenjäger E 1976 [Studies on thyroid function by means of TRH tests in simple goiter before and after strumectomy]. Schweiz Med Wochenschr 106:1084-1088
43. Verhaert N, Vander Poorten V, Delaere P, Bex M, Debruyne F 2006 Levothyroxine replacement therapy after thyroid surgery. B-ENT 2:129-133 (Pubitemid 47528254)
44. Prichard RS, Easwarahingham N, Suliburk J, Sidhu SB, Sywak MS, Delbridge LW 2010 Hypothyroidism following thyroid nodulectomy: comparison with thyroid lobectomy: Es18p. [Abstract]. ANZ J Surg 80(Supp 1):A28-A29
45. May RE 1972 Hypothyroidism after partial thyroidectomy. BMJ 1:632.4
46. Beisa V, Kazanavicius D, Skrebunas A, Simutis G, Sileikis A, Strupas K 2010 Prognosis of thyroid function after hemithyroidectomy. Cent Eur J Med 6:152-157
47. Lankarani M, Mahmoodzadeh H, Poorpezeshk N, Soleimanpour B, Haghpanah V, Heshmat R, Aghakhani S, Shooshtarizadeh P 2008 Hypothyroidism following thyroid surgery. Acta Medica Iranica 46:225-232 (Pubitemid 351884334)
48. Dobrinja C, Trevisan G, Piscopello L, Fava M, Liguori G 2010 Comparison between thyroidectomy and hemithyroidectomy in treatment of single thyroid nodules identified as indeterminate follicular lesions by fine-needle aspiration cytology. Ann Ital Chir 81: 403-410; discussion 410-411
49. Lombardi G, Panza N, Lupoli G, Leonello D, Carlino M, Minozzi M1983 Study of the pituitary-thyroid axis in euthyroid goiter after partial thyroidectomy. J Endocrinol Invest 6:485-487 (Pubitemid 14198805)
50. Hedman I, Jansson S, Lindberg S 1986 Need for thyroxine in patients lobectomised for benign thyroid disease as assessed by follow-up on average fifteen years after surgery. Acta Chir Scand 152: 481-486 (Pubitemid 16004816)
51. Cheung P, Boey J, Wong J 1986 Thyroid function after hemithyroidectomy for benign nodules. World J Surg 10:718-723 (Pubitemid 16096432)
52. Lee JK, Wu CW, Tai FT, Lin HD, Ching KN 1989 Changes in serum thyroid hormone and thyroglobulin levels after surgical treatments for toxic and non-toxic goiter. Thyroidology 1:131-136
53. Berglund J, Bondeson L, Christensen SB, Tibblin S 1991 The influence of different degrees of chronic lymphocytic thyroiditis on thyroid function after surgery for benign, non-toxic goitre. Eur J Surg 157:257-260
54. McHenry CR, Slusarczyk SJ 2000 Hypothyroidism following hemithyroidectomy: incidence, risk factors, and management. Surgery 128:994-998
55. Lindblom P, Valdemarsson S, Lindergård B, Westerdahl J, Bergenfelz A 2001 Decreased levels of ionized calcium one year after hemithyroidectomy: importance of reduced thyroid hormones. Horm Res 55:81-87 (Pubitemid 32757363)
56. Buchanan MA, Lee D 2001 Thyroid auto-antibodies, lymphocytic infiltration and the development of post-operative hypothyroidism following hemithyroidectomy for non-toxic nodular goitre. J R Coll Surg Edinb 46:86-90 (Pubitemid 32331458)
57. Guberti A, Sianesi M, Del Rio P, Bertocchi A, Dazzi D, Guareschi C, Robuschi G 2002 Thyroid function and goiter recurrence after thyroid lobectomy in elderly subjects. J Endocrinol Invest 25:71-72
58. Farkas EA, King TA, Bolton JS, Fuhrman GM 2002 A comparison of total thyroidectomy and lobectomy in the treatment of dominant thyroid nodules. Am Surg 68:678-682; discussion 682-683
59. Piper HG, Bugis SP, Wilkins GE, Walker BA, Wiseman S, Baliski CR 2005 Detecting and defining hypothyroidism after hemithyroidectomy. Am J Surg 189:587-591 (Pubitemid 40602949)
60. Rosário PW, Pereira LF, Borges MA, Alves MF, Purisch S 2006 Factors predicting the occurrence of hypothyroidism after hemithyroidectomy. Thyroid 16:707
61. Miller FR, Paulson D, Prihoda TJ, Otto RA 2006 Risk factors for the development of hypothyroidism after hemithyroidectomy. Arch Otolaryngol Head Neck Surg 132:36-38 (Pubitemid 43127961)
62. Seiberling KA, Dutra JC, Bajaramovic S 2007 Hypothyroidism following hemithyroidectomy for benign nontoxic thyroid disease. Ear Nose Throat J 86:295-299 (Pubitemid 351267547)
63. Wormald R, Sheahan P, Rowley S, Rizkalla H, Toner M, Timon C 2008 Hemithyroidectomy for benign thyroid disease: who needs follow-up for hypothyroidism? Clin Otolaryngol 33:587-591
64. De Carlucci Jr D, Tavares MR, Obara MT, Martins LA, Hojaij FC, Cernea CR 2008 Thyroid function after unilateral total lobectomy: risk factors for postoperative hypothyroidism. Arch Otolaryngol Head Neck Surg 134:1076-1079
65. Moon HG, Jung EJ, Park ST, Jung TS, Jeong CY, Ju YT, Lee YJ, Hong SC, Choi SK, Ha WS 2008 Thyrotropin level and thyroid volume for prediction of hypothyroidism following hemithyroidectomy in an Asian patient cohort. World J Surg 32:2503-2508
66. Vaiman M, Nagibin A, Hagag P, Kessler A, Gavriel H 2008 Hypothyroidism following partial thyroidectomy. Otolaryngol Head Neck Surg 138:98-100 (Pubitemid 350299637)
67. Koh YW, Lee SW, Choi EC, Lee JD, Mok JO, Kim HK, Koh ES, Lee JY, Kim SC 2008 Prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis. Eur Arch Otorhinolaryngol 265:453-457
68. Su SY, Grodski S, Serpell JW 2009 Hypothyroidism following hemithyroidectomy: a retrospective review. Ann Surg 250:991-994
69. Phitayakorn R, Narendra D, Bell S, McHenry CR 2009 What constitutes adequate surgical therapy for benign nodular goiter? J Surg Res 154:51-55
70. Barczyñski M, Konturek A, Gołkowski F, Hubalewska-Dydejczyk A, Cichoñ S, Nowak W 2010 Five-year follow-up of a randomized clinical trial of unilateral thyroid lobectomy with or without postoperative levothyroxine treatment. World J Surg 34:1232-1238
71. Yetkin G, Uludag M, Onceken O, Citgez B, Isgor A, Akgun I 2010 Does unilateral lobectomy suffice to manage unilateral nontoxic goiter? Endocr Pract 16:36-41
72. Spanheimer PM, Sugg SL, Lal G, Howe JR, Weigel RJ 2011 Surveillance and intervention after thyroid lobectomy. Ann Surg Oncol 18:1729-1733
73. Tomoda C, Ito Y, Kobayashi K, Miya A, Miyauchi A 2011 Subclinical hypothyroidism following hemithyroidectomy: a simple risk-scoring system using age and preoperative thyrotropin level. ORL J Otorhinolaryngol Relat Spec 73:68-71
74. Chu KK, Lang BH 23 June 2011 Clinicopathologic predictors for early and late biochemical hypothyroidism after hemithyroidectomy. Am J Surg doi: org/10.1016/j.amjsurg.2011.03.004
75. Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frölich M, Westendorp RG 2004 Thyroid status, disability and cognitive function, and survival in old age. JAMA 292:2591-2599 (Pubitemid 39577515)
76. Biondi B 2008 Should we treat all subjects with subclinical thyroid disease the same way? Eur J Endocrinol 159:343-345
77. Duntas LH, Biondi B 2011 New insights into subclinical hypothyroidism and cardiovascular risk. Semin Thromb Hemost 37:27-34
78. Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SH 2008 The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis. J Clin Endocrinol Metab 93:2998-3007
79. Dayan CM, Saravanan P, Bayly G 2002 Whose normal thyroid function is better - yours or mine? Lancet 360:353
80. Zimmermann MB 2009 Iodine deficiency. Endocr Rev 30:376-408
81. Andersson M, Takkouche B, Egli I, Allen HE, de Benoist B 2005 Current global iodine status and progress over the last decade towards the elimination of iodine deficiency. Bull World Health Organ 83:518-525 (Pubitemid 41003327)