The Immature Platelet Fraction: An assessment of its application to a routine clinical laboratory

Australian Journal of Medical Science

Volumn 33, Issue 2, 2012, Pages 48-57

  Sinclair, Leanne ^a  

^a WESLEY HOSPITAL   (Australia)

Author keywords

Immature platelet fraction; Immune thrombocytopenia; Reticulated platelets; Sysmex; Thrombocytopenia

Indexed keywords

BONE MARROW BIOPSY; CLINICAL LABORATORY; COMPARATIVE STUDY; CONTROLLED STUDY; HOSPITAL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMATURE PLATELET FRACTION; MAJOR CLINICAL STUDY; MEGAKARYOCYTE; REFERENCE VALUE; REPRODUCIBILITY; REVIEW; ROOM TEMPERATURE; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

EID: 84863540759     PISSN: 10381643     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Abe Y, Wada H, Tomatsu H, Sakaguchi A, Nishioka J, Yabu Y, Onishi K, Nakatani K, Morishita Y, Oguni S, Nobori T. 2006. A simple technique to determine thrombopoiesis level using the immature platelet fraction (IPF). Thromb Res 118: 463-469.
2. Ault KA, Rinder HM, Mitchell J, Carmody MB, Vary CP, Hillman RS. 1992. The significance of platelets with increased RNA content (reticulated platelets). A measure of the rate of thrombopoiesis. Am J Clin Pathol 98: 637-646.
3. Barsam SJ, Psaila B, Forestier M, Page LK, Sloane PA, Geyer JT, Villarica GO, Ruisi MM, Gernsheimer TB, Beer JH, Bussel JB. 2011. Platelet production and platelet destruction: assessing mechanisms of treatment effect in immune thrombocytopenia. Blood 117: 5723-5732.
4. Briggs C, Hart D, Kunka S, Oguni S, Machin S. 2006. Immature platelet fraction measurement: a future guide to platelet transfusion requirement after haematopoietic stem cell transplantation. Transfus Med 16: 101-109.
5. Briggs C, Kunka S, Hart D, Oguni S, Machin S. 2004. Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. Br J Haematol 126: 93-99.
6. Cannavo I, Ferrero-Vacher C, Sudaka I, Aquaronne D, Berthier F, Raynaud S. 2010. [Assessment of an immature platelet fraction (IPF%) in the diagnosis of thrombocytopenia]. Article in French. Ann Biol Clin (Paris) 68: 415-420.
7. Cesari F, Marcucci R, Caporale R, Paniccia R, Romano E, Gensini GF, Abbate R, Gori AM. 2008. Relationship between high platelet turnover and platelet function in high-risk patients with coronary artery disease on dual antiplatelet therapy. Thromb Haemost 99:930-935.
8. Cho YG, Lee JH, Kim DS, Lee HS, Choi SI. 2007. [Clinical usefulness of the simple technique to diagnose thrombocytopenia using immature platelet fraction]. Article in Korean. Korean J Lab Med 27: 1-6.
9. Chong BH. 2009. Primary immune thrombocytopenia: understanding pathogenesis is the key to better treatments. J Thromb Haemost 7: 319-321.
10. Clinical Laboratory Standards Institute, CLSI. 2008. Defining, Establishing, & Verifying Reference Intervals in the Clinical Laboratory; Approved Guidelines-third edition. C28-A3 Vol. 28. no. 30. http://www.clsi.org/source/orders/free/c28-a3.pdf. Accessed 20th April 2011.
11. Cremer M, Paetzold J, Schmalisch G, Hammer H, Loui A, Dame C, Weimann A. 2009. Immature platelet fraction as a novel laboratory parameter predicting the course of neonatal thrombocytopenia. Br J Haematol 144: 619-621.
12. De Mast Q, De Groot PG, Van Heerde WL, Roestenberg M, van Velzen JF, Verbruggen B, Roest M, McCall M, Nieman AE, Westendorp J, Syafruddin D, Fijnheer R, van Dongen-Lases EC, Sauerwein RW, van der Ven AJ. 2010. Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br J Haematol 151: 495-503.
13. Di Mario A, Garzia M, Leone F, Arcangeli A, Pagano L, Zini G. 2009. Immature platelet fraction (IPF) in hospitalized patients with neutrophilia and suspected bacterial infection. J Infect 59: 201-206.
14. Emilia G, Longo G, Luppi M, Gandini G, Morselli M, Ferrara L, Amarri S, Cagossi K, Torelli G. 2001. Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura. Blood 97: 812-814.
15. Garibaldi B, Malani R, Yeh HC, Lipson E, Michell D, Bennett M, Moliterno A, McDevitt MA, Kickler TS. 2009. Estimating platelet production in patients with HIV-related thrombocytopenia using the Immature Platelet Fraction. Am J Hematol 84: 852-854.
16. Goncalo AP, Barbosa IL, Campilho F, Campos A, Mendes C. 2011. Predictive value of immature reticulocyte and platelet fractions in hematopoietic recovery of allograft patients. Transplant Proc 43: 241-243.
17. Grove EL, Hvas AM, Kristensen SD. 2009. Immature platelets in patients with acute coronary syndromes. Thromb Haemost 101: 151-156.
18. Haver VM, Gear AR. 1981. Functional fractionation of platelets. J Lab Clin Med 41: 587-598.
19. Hong KH, Kim HK, Kim JE, Jung JS, Han KS, Cho HI. 2009. Prognostic value of immature platelet fraction and plasma thrombopoietin in disseminated intravascular coagulation. Blood Coagul Fibrinolysis 20: 409-414.
20. Ingram M, Coopersmith A. 1969. Reticulated platelets following acute blood loss. Br J Haematol 17: 225-229.
21. Jung H, Jeon HK, Kim HJ, Kim SH. 2010. Immature platelet fraction: establishment of a reference interval and diagnostic measure for thrombocytopenia. Korean J Lab Med 30: 451-459. (Erratum in Korean J Lab Med 2012; 32: 169).
22. Karpatkin S. 1978. Heterogeneity of human platelets. VI. Correlation of platelet function and platelet volume. Blood 51: 307-316.
23. Kaushansky K, Lin N, Grossman A, Humes J, Sprugel KH, Broudy VC.1996. Thrombopoietin expands erythroid granulocytemacrophage and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 236: 265-269.
24. Kickler TS, Oguni S, Borowitz MJ. 2006. A clinical evaluation of high fluorescent platelet fraction percentage in thrombocytopenia. Am J Clin Pathol 125: 282-287.
25. Kihara H, Ohno N, Karakawa S, Mizoguchi Y, Fukuhara R, Hayashidani M, Nomura S, Nakamura K, Kobayashi M. 2010. Significance of immature platelet fraction and CD41-positive cells at birth in early onset neonatal thrombocytopenia. Int J Hematol 91: 245-251.
26. Kim HR, Park BR, Lee MK, Park AJ, Ahn JY. 2007. [Comparison of an immature platelet fraction and reticulated platelets in liver cirrhosis]. Article in Korean. Korean J Lab Med 27: 7-12.
27. Kraytman M. 1973. Platelet size in thrombocytopenias and thrombocytosis of various origin. Blood 41: 587-598.
28. Kurata Y, Hayashi S, Kiyoi T, Kosugi S, Kashiwagi H, Honda S, Tomiyama Y. 2001. Diagnostic value of tests for reticulated platelets, plasma glycocalicin, and thrombopoietin levels for discriminating between hyperdestructive and hypoplastic thrombocytopenia. Am J Clin Pathol 115: 656-664.
29. Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA; American Society of Hematology. 2011. The American Society of Hematology 2011 evidence based practice guideline for immune thrombocytopenia. Blood 117: 4190-4207.
30. Nomura T, Kubota Y, Kitanaka A, Kurokouchi K, Inage T, Saigo K, Iseki K, Baba N, Yamaoka G, Arai T, Taminato T. 2010. Immature platelet fraction measurement in patients with chronic liver disease: a convenient marker for evaluating cirrhotic change. Int J Hematol 32: 299-306.
31. O'Malley CJ, Rasko JE, Basser RL, McGrath KM, Cebon J, Grigg AP, Hopkins W, Cohen B, O'Byrne J, Green MO, Fox RM, Berndt MC, Begley CG. 1996. Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation. Blood 88: 3288-3298.
32. Osei-Bimpong A. 2009. The effect of storage on the clinical utility of the immature platelet fraction. Hematology 14: 118-121.
33. Pons I, Monteagudo M, Lucchetti G, Munoz L, Perea G, Colomina I, Guiu J, Obiols J. 2010. Correlation between immature platelet fraction and reticulated platelets. Usefulness in the etiology diagno-sis of thrombocytopenia. Eur J Haematol 85: 158-163.
34. Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B, Grainger J, Greer I, Hunt BJ, Imbach PA, Lyons G, McMillan R, Rodeghiero F, Sanz MA, Tarantino M, Watson S, Young, Kuter DJ. 2010. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 115: 168-186.
35. Richards EM, Baglin TP. 1995. Quantitation of reticulated platelets: methodology and clinical application. Br J Haematol 91: 445-451.
36. Rinder HM, Bonan JL, Anandan S, Rinder CS, Rodrigues PA, Smith BR. 1993. Noninvasive measurement of platelet kinetics in normal and hypertensive pregnancies. Am J Obstet Gynecol 170: 117-122.
37. Rinder HM, Munz UJ, Ault KA, Bonan JL, Smith BR. 1993. Reticulated platelets in the evaluation of thrombopoietic disorders. Arch Pathol Lab Med 117: 606-610.
38. Rinder HM, Schuster JE, Rinder CS, Wang C, Schweidler HJ, Smith BR. 1998. Correlation of thrombosis with increased platelet turnover in thrombocytosis. Blood 91: 1288-1294.
39. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kuhne T, Ruggeri M, George JN. 2009. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 113: 2386-2393.
40. Ruisi MM, Psaila B, Ward MJ, Villarica G, Bussel JB. 2010. Stability of measurement of the immature platelet fraction. Am J Hematol 85: 622-624.
41. Saigo K, Sakotab Y, Masudab Y, Matsunagab K, Takenokuchib M, Nishimurab K, Sugimotoa T, Sakuraia K, Hashimotoa M, Yanaic T, Hayakawac A, Takeshimac Y, Nomurad T, Kubota Y, Kumagai S. 2008. Automatic detection of immature platelets for decision making regarding platelet transfusion indications for pediatric patients. Transfus Apher Sci 38: 127-132.
42. Saigo K, Takenokuchi M, Imai J, Numata K, Isono S, Zenibayashi M, Tanioka H, Yoshioka T, Nishizawa A, Takada M, Nomura T, Kubota Y. 2009. Usefulness of the immature platelet fraction for the clinical evaluation of myelodysplastic syndromes. Lab Haematol 15: 13-16.
43. Sakaguchi A, Wada H, Abe Y, Tomatsu H, Nishioka J, Morishita Y, Okuni S, Usui M, Isaji S, Nobori T. 2008. [Analysis of platelet production following liver transplantation using the immature platelet fraction (IPF) parameter]. Article in Japanese. Rinsho Byori 56: 29-35.
44. Scaramucci C, De Blasi R, Tribuzi S, Carlini A. 2010. Immature platelet fraction as a predictive index of sepsis. Crit Care 14: R34.
45. Semple JW, Provan D, Garvey MB, Freedman J. 2010. Recent progress in understanding the pathogenesis of immune thrombocytopenia. Curr Opin Hematol 17: 590-595.
46. Sola-Visner M, Sallmon H, Brown R. 2009. New insights into the mechanisms of non-immune thrombocytopenia in neonates. Semin Perinatol 33: 43-51.
47. Stasi R, Sarpatwari A, Segal JB, Osborn J, Evangelista ML, Cooper N, Provan D, Newland A, Amadori S, Bussel JB. 2009. Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review. Blood 113: 1231-1240.
48. Sugimori N, Kondo Y, Shibayama M, Omote M, Takami A, Sugimori C, Ishiyama K, Yamazaki H, Nakao S. 2009. Aberrant increase in the immature platelet fraction in patients with myelodysplastic syndrome: a marker of karyotypic abnormalities associated with poor prognosis. Eur J Haematol 82: 54-60.
49. Takami A, Shibayama M, Orito M, Omote M, Okumura H, Yamashita T, Shimadoi S, Yoshida T, Nakao S, Asakura H. 2007. Immature platelet fraction for prediction of platelet engraftment after allogeneic stem cell transplantation. Bone Marrow Transplant 39: 501-507.
50. Yamaoka G, Kubota Y, Nomura T, Inage T, Arai T, Kitanaka K, Saigo K, Iseki K, Baba N, Taminato T. 2010. The immature platelet fraction is a useful marker for predicting the timing of platelet recovery in patients with cancer after chemotherapy and hematopoietic stem cell transplantation. Int J Lab Hematol 32: e208-e216.
51. Zhou B, Zhao H, Yang RE, Han ZC. 2005. Multi-dysfunctional pathophysiology in ITP. Crit Rev Oncol Hematol 54: 107-116.
52. Zucker ML, Murphy CA, Rachel JM, Martinez GA, Abhyankar S, McGuirk JP, Reid KJ, Plapp FV. 2006. Immature platelet fraction as a predictor of platelet recovery following hematopoietic progenitor cell transplantation. Lab Hematol 12: 125-130.