Contrast-enhanced functional blood volume imaging (CE-fBVI): Enhanced sensitivity for brain activation in humans using the ultrasmall superparamagnetic iron oxide agent ferumoxytol

NeuroImage

Volumn 62, Issue 3, 2012, Pages 1726-1731

  Qiu, Deqiang ^a   Zaharchuk, Greg ^a   Christen, Thomas ^a   Ni, Wendy W ^a,b   Moseley, Michael E ^a  

^a STANFORD UNIVERSITY   (United States)

^b Stanford University   (United States)

Author keywords

Blood pool; Brain activation; Contrast agents; FMRI; Human; MRI; USPIO

Indexed keywords

FERUMOXYTOL; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

ADULT; ARTICLE; BLOOD VOLUME; BOLD SIGNAL; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; CEREBRAL BLOOD VOLUME; CONTRAST ENHANCED FUNCTIONAL BLOOD VOLUME IMAGING; CONTRAST ENHANCEMENT; CONTRAST TO NOISE RATIO; FRONTAL LOBE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; IMAGE QUALITY; INFERIOR FRONTAL LOBE; MALE; MENTAL TASK; NORMAL HUMAN; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; RADIOSENSITIVITY; TEMPORAL LOBE;

ADULT; BLOOD VOLUME; BLOOD VOLUME DETERMINATION; BRAIN; BRAIN MAPPING; CONTRAST MEDIA; FERUMOXYTOL; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PSYCHOMOTOR PERFORMANCE; SIGNAL-TO-NOISE RATIO; YOUNG ADULT;

EID: 84863503167     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2012.05.010     Document Type: Article

References (22)

1. Atkinson J.L., Anderson R.E., Sundt T.M. The effect of carbon dioxide on the diameter of brain capillaries. Brain Res. 1990, 517:333-340.
2. Belliveau J.W., Kennedy D.N., McKinstry R.C., Buchbinder B.R., Weisskoff R.M., Cohen M.S., Vevea J.M., Brady T.J., Rosen B.R. Functional mapping of the human visual cortex by magnetic resonance imaging. Science 1991, 254:716-719.
3. Boxerman J.L., Hamberg L.M., Rosen B.R., Weisskoff R.M. MR contrast due to intravascular magnetic susceptibility perturbations. Magn. Reson. Med. 1995, 34:555-566.
4. Buxton R.B., Wong E.C., Frank L.R. Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn. Reson. Med. 1998, 39:855-864.
5. Duelli R., Kuschinsky W. Changes in brain capillary diameter during hypocapnia and hypercapnia. J. Cereb. Blood Flow Metab. 1993, 13:1025-1028.
6. Harel N., Lin J., Moeller S., Ugurbil K., Yacoub E. Combined imaging-histological study of cortical laminar specificity of fMRI signals. Neuroimage 2006, 29:879-887.
7. Kruger G., Glover G.H. Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn. Reson. Med. 2001, 46:631-637.
8. Leite F.P., Tsao D., Vanduffel W., Fize D., Sasaki Y., Wald L.L., Dale A.M., Kwong K.K., Orban G.A., Rosen B.R., Tootell R.B., Mandeville J.B. Repeated fMRI using iron oxide contrast agent in awake, behaving macaques at 3 Tesla. Neuroimage 2002, 16:283-294.
9. Lin A.-L., Fox P.T., Yang Y., Lu H., Tan L.-H., Gao J.-H. Evaluation of MRI models in the measurement of CMRO2and its relationship with CBF. Magn. Reson. Med. 2008, 60:380-389.
10. Lu H., Golay X., Pekar J.J., Van Zijl P.C. Functional magnetic resonance imaging based on changes in vascular space occupancy. Magn. Reson. Med. 2003, 50:263-274.
11. Lu H., Patel S., Luo F., Li S.J., Hillard C.J., Ward B.D., Hyde J.S. Spatial correlations of laminar BOLD and CBV responses to rat whisker stimulation with neuronal activity localized by Fos expression. Magn. Reson. Med. 2004, 52:1060-1068.
12. Lu H., Scholl C.A., Zuo Y., Stein E.A., Yang Y. Quantifying the blood oxygenation level dependent effect in cerebral blood volume-weighted functional MRI at 9.4T. Magn. Reson. Med. 2007, 58:616-621.
13. Malonek D., Grinvald A. Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping. Science 1996, 272:551-554.
14. Mandeville J.B., Marota J.J., Kosofsky B.E., Keltner J.R., Weissleder R., Rosen B.R., Weisskoff R.M. Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn. Reson. Med. 1998, 39:615-624.
15. Mandeville J.B., Jenkins B.G., Chen Y.C., Choi J.K., Kim Y.R., Belen D., Liu C., Kosofsky B.E., Marota J.J. Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 T. Magn. Reson. Med. 2004, 52:1272-1281.
16. Ogawa S., Lee T.M., Nayak A.S., Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn. Reson. Med. 1990, 14:68-78.
17. Ogawa S., Menon R.S., Tank D.W., Kim S.G., Merkle H., Ellermann J.M., Ugurbil K. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys. J. 1993, 64:803-812.
18. Triantafyllou C., Hoge R.D., Krueger G., Wiggins C.J., Potthast A., Wiggins G.C., Wald L.L. Comparison of physiological noise at 1.5 T, 3 T and 7 T and optimization of fMRI acquisition parameters. Neuroimage 2005, 26:243-250.
19. Weinstein J.S., Varallyay C.G., Dosa E., Gahramanov S., Hamilton B., Rooney W.D., Muldoon L.L., Neuwelt E.A. Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J. Cereb. Blood Flow Metab. 2010, 30:15-35.
20. Weisskoff R.M., Zuo C.S., Boxerman J.L., Rosen B.R. Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn. Reson. Med. 1994, 31:601-610.
21. Yacoub E., Harel N., Ugurbil K. High-field fMRI unveils orientation columns in humans. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:10607-10612.
22. Zhao F., Wang P., Hendrich K., Ugurbil K., Kim S.G. Cortical layer-dependent BOLD and CBV responses measured by spin-echo and gradient-echo fMRI: insights into hemodynamic regulation. Neuroimage 2006, 30:1149-1160.