Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: Clinical compound TD-2749

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4849-4853

  Long, Daniel D ^a   Armstrong, Scott R ^a   Beattie, David T ^a   Choi, Seok Ki ^a   Fatheree, Paul R ^a   Gendron, Roland A L ^a   Goldblum, Adam A ^a   Humphrey, Patrick P ^a   Marquess, Daniel G ^a   Shaw, Jeng Pyng ^a   Smith, Jacqueline A M ^a   Derek Turner, S ^a   Vickery, Ross G ^a  

^a THERAVANCE INC   (United States)

Author keywords

5 HT4 receptor agonist; Alzheimer's; GI motility; Multivalent approach; TD 2749

Indexed keywords

CISAPRIDE; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; TD 2749; TEGASEROD; THRX 194556; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; GUINEA PIG; IN VIVO STUDY; INTESTINE MOTILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; REACTION OPTIMIZATION;

ADMINISTRATION, ORAL; ANIMALS; CELL LINE; DRUG DISCOVERY; HETEROCYCLIC COMPOUNDS; HUMANS; MALE; MOLECULAR STRUCTURE; ORGAN SPECIFICITY; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN 5-HT4 RECEPTOR AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863483799     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.034     Document Type: Article

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