Mechanically untying a protein slipknot: Multiple pathways revealed by force spectroscopy and steered molecular dynamics simulations

Journal of the American Chemical Society

Volumn 134, Issue 25, 2012, Pages 10428-10435

  He, Chengzhi ^a   Genchev, Georgi Z ^b   Lu, Hui ^b,c   Li, Hongbin ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b University of Illinois at Chicago   (United States)

^c BEIJING HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AFM; C-TERMINUS; CONTOUR LENGTHS; FORCE SPECTROSCOPY; INTERMEDIATE STATE; KINETIC PARTITIONING MECHANISMS; MECHANICAL UNFOLDING; MOLECULAR MECHANISM; MULTIPLE PATHWAYS; POLYPEPTIDE CHAIN; PROTEIN ENGINEERING; PROTEIN STRUCTURES; SINGLE MOLECULE; STEERED MOLECULAR DYNAMICS; STEERED MOLECULAR DYNAMICS SIMULATIONS; STRUCTURAL ELEMENTS; TWO-STATE; UNFOLDING PROCESS;

ATOMIC FORCE MICROSCOPY; CONFORMATIONS; GENETIC ENGINEERING; MOLECULAR DYNAMICS; MOLECULES;

PROTEINS;

POLYPEPTIDE; PROTEIN; PROTEIN AFV3 109; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC FORCE MICROSCOPY; MOLECULAR DYNAMICS; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTEIN UNFOLDING; SIMULATION; SPECTROSCOPY;

MICROSCOPY, ATOMIC FORCE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEINS;

EID: 84863470496     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3003205     Document Type: Article

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