GABAB receptors do not internalize after baclofen treatment, possibly due to a lack of β-arrestin association: Study with a real-time visualizing assay

Synapse

Volumn 66, Issue 9, 2012, Pages 759-769

  Sudo, Yuka ^a,b   Hojo, Minoru ^a   Ando, Yuko ^a   Takada, Masafumi ^a   Murata, Hiroaki ^a   Kurata, Shinji ^a   Nishida, Noriyuki ^a   Uezono, Yasuhito ^a,b  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

arrestin; Endocytosis; GABAB receptor; GRK; Internalization

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; BETA ARRESTIN; BETA ARRESTIN 1; BETA ARRESTIN 2; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL;

ARTICLE; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; INTERNALIZATION; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

ANIMALS; ARRESTINS; BACLOFEN; CELL LINE; CRICETINAE; FLUORESCENCE RESONANCE ENERGY TRANSFER; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GABA-B RECEPTOR AGONISTS; HUMANS; RATS; RECEPTORS, GABA-B;

EID: 84863458938     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21565     Document Type: Article

References (29)

1. Agnati LF, Ferré S, Lluis C, Franco R, Fuxe K. 2003. Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacol Rev 55: 509-550.
2. Ando Y, Hojo M, Kanaide M, Takada M, Sudo Y, Shiraishi S, Sumikawa K, Uezono Y. 2011. S(+)-ketamine suppresses desensitization of γ-aminobutyric acid type B receptor-mediated signaling by inhibition of the interaction of γ-aminobutyric acid type B receptors with G protein-coupled receptor kinase 4 or 5. Anesthesiology 114: 401-411.
3. B receptors. Physiol Rev 84: 835-867.
4. B receptors. J Biol Chem 273: 26361-26367.
5. B receptor cell surface stability. J Biol Chem 279: 12565-12573.
6. Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG. 2004. Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27: 107-144.
7. B receptor function. EMBO J 20: 2152-2159.
8. B receptors in CHO-K1 cells. Eur J Pharmacol 481: 15-23.
9. Grampp T, Sauter K, Markovic B, Benke D. 2007. Gamma-aminobutyric acid type B receptors are constitutively internalized via the clathrin-dependent pathway and targeted to lysosomes for degradation. J Biol Chem 282: 24157-24165.
10. Groer CE, Schmid CL, Jaeger AM, Bohn LM. 2011. Agonist-directed interactions with specific β-arrestins determine μ-opioid receptor trafficking, ubiquitination, and dephosphorylation. J Biol Chem 286: 31731-31741.
11. B1. Proc Natl Acad Sci USA 107: 13924-13929.
12. B2 subunit with GRK4 or GRK5. J Cell Physiol 210: 237-245.
13. Kelly E, Bailey CP, Henderson G. 2008. Agonist-selective mechanisms of GPCR desensitization. Br J Pharmacol 153( Suppl 1): S379-S388.
14. B receptor heterodimer upon chronic capsaicin stimulation. Eur J Neurosci 25: 1402-1416.
15. Luttrell LM, Lefkowitz RJ. 2002. The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 115(Pt 3): 455-465.
16. Miyawaki A, Tsien RY. 2000. Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods Enzymol 327: 472-500.
17. Nagai T, Ibata K, Park ES, Kubota M, Mikoshiba K, Miyawaki A. 2002. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol 20: 87-90.
18. Nielsen JF, Hansen HJ, Sunde N, Christensen JJ. 2002. Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofen. Clin Neurol Neurosurg 104: 142-145.
19. 2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal 4: ra51.
20. Perroy J, Adam L, Qanbar R, Chénier S, Bouvier M. 2003. Phosphorylation-independent desensitization of GABA(B) receptor by GRK4. EMBO J 22: 3816-3824.
21. Riven I, Kalmanzon E, Segev L, Reuveny E. 2003. Conformational rearrangements associated with the gating of the G protein-coupled potassium channel revealed by FRET microscopy. Neuron 38: 225-235.
22. Rizzo MA, Springer GH, Granada B, Piston DW. 2004. An improved cyan fluorescent protein variant useful for FRET. Nat Biotechnol 22: 445-449.
23. Shenoy SK, Lefkowitz RJ. 2011. β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci 32: 521-533.
24. Slonimski M, Abram SE, Zuniga RE. 2004. Intrathecal baclofen in pain management. Reg Anesth Pain Med 29: 269-276.
25. B receptors by protein kinases and receptor trafficking. Adv Pharmacol 58: 113-122.
26. + channels by GABA-B receptors expressed in Xenopus oocytes. Neuroreport 9: 583-587.
27. B2 subunit to G proteins: Evidence from Xenopus oocyte and baby hamster kidney cell expression system. Am J Physiol Cell Physiol 290: C200-C207.
28. B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons. J Biol Chem 283: 24641-24648.
29. B receptors using an α-bungarotoxin tag. J Biol Chem 283: 34745-34752.