Fifty percent reduced-dose cerebral CT perfusion imaging of Alzheimer's disease: Regional blood flow abnormalities

American Journal of Alzheimer's Disease and other Dementias

Volumn 27, Issue 4, 2012, Pages 267-274

  Tang, Zhen ^a   Pi, Xiaoling ^b   Chen, Feng ^a   Shi, Linghua ^b   Gong, Haiting ^c   Fu, Hongmei ^d   Qu, Zhengwan ^d  

^a No 6 People's Hospital   (China)

^b Pudong New District Gongli Hospital   (China)

^c FUDAN UNIVERSITY   (China)

^d Pudong New District Mental Health Centre   (China)

Author keywords

blood perfusion; CBF; CBV; cognition; dementia; logistic regression analysis

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BASAL GANGLION; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN PERFUSION; CEREBROVASCULAR DISEASE; COMPUTED TOMOGRAPHY PERFUSION IMAGING; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; RADIATION DOSE; SENSITIVITY AND SPECIFICITY; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; TEMPORAL CORTEX;

EID: 84863454374     PISSN: 15333175     EISSN: 19382731     Source Type: Journal    
DOI: 10.1177/1533317512447885     Document Type: Article

References (16)

1. Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimer disease. Nat Rev Neurol. 2011;7(3):137-152.
2. Zimny A, Sasiadek M, Leszek J, Czarnecka A, Trypka E, Kiejna A. Does perfusion CT enable differentiating Alzheimer's disease from vascular dementia and mixed dementia? A preliminary report. J Neurol Sci. 2007;257(6):114-120. (Pubitemid 46856514)
3. Jagust W. Positron emission tomography and magnetic resonance imaging in the diagnosis and prediction of dementia. Alzheimers Dement. 2006;2(1):36-42. (Pubitemid 43264482)
4. Silverman DH, Small GW, Chang CY, et al. Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome. JAMA. 2001;286(17):2120-2127. (Pubitemid 34041597)
5. Hanyu H, Shimizu S, Hirao K, et al. Differentiation of dementia with lewy bodies from Alzheimer's disease using Mini-Mental State Examination and brain perfusion SPECT. J Neurol Sci. 2006;250(7):97-102. (Pubitemid 44665937)
6. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198.
7. Dean PM, Feldman DM, Morere D, Morton D. Clinical evaluation of the mini-mental state exam with culturally deaf senior citizens. Arch Clin Neuropsychol. 2009;24(8):753-760.
8. Chui H. Neuropathology lessons in vascular dementia. Alzheimer Dis Assoc Disord. 2005;19(1):45-52. (Pubitemid 40940999)
9. Grammas P. Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease. J Neuroinflammation. 2011;8:26.
10. Terry RD, Peck A, De Teresa R, Schechter R, Horoupian DS. Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol. 1981;10(2):184-192. (Pubitemid 11053105)
11. Harris RJ, Symon L, Branston NM, Bayhan M. Changes in extracellular calcium activity in cerebral ischaemia. J Cereb Blood Flow Metab. 1981;1(2):203-209. (Pubitemid 12250019)
12. Whitmer RA, Sidney S, Selby J, Johnston SC, Yaffe K. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology. 2005;64(2):277-281.
13. Cenic A, Nabavi DG, Craen RA, Gelb AW, Lee TY. Dynamic CT measurement of cerebral blood flow: a validation study. AJNR Am J Neuroradiol. 1999;20(1):63-73. (Pubitemid 30417673)
14. Yang Y, Engelien W, Xu S, Gu H, Silbersweig DA, Stern E. Transit time, trailing time, and cerebral blood flow during brain activation: measurement using multislice, pulsed spin-labeling perfusion imaging. Magn Reson Med. 2000;44(5): 680-685.
15. Miles KA, Griffiths MR. Perfusion CT: a worthwhile enhancement? Br J Radiol. 2003;76(904):220-231. (Pubitemid 36582066)
16. Fieselmann A, Kowarschik M, Ganguly A, Hornegger J, Fahrig R. Deconvolution-based CT and MR brain perfusion measurement: theoretical model revisited and practical implementation details. Int J Biomed Imaging. 2011;2011: 467-563