Insulin prevents leptin inhibition of RM1 prostate cancer cell growth

Pathology and Oncology Research

Volumn 18, Issue 2, 2012, Pages 499-507

  Ribeiro, Andreia M ^a   Pereira, Sofia ^a   Andrade, Sara ^a   Costa, Madalena ^a   Lopes, Carlos ^a   Aguas, Artur P ^a   Monteiro, Mariana P ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Cellular proliferation; Insulin; Leptin; Obesity; Prostate cancer; RM1 cells

Indexed keywords

INSULIN; INSULIN RECEPTOR; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; RESAZURIN; SOMATOMEDIN C;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CULTURE MEDIUM; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MOUSE; NONHUMAN; PROSTATE CANCER;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DRUG THERAPY, COMBINATION; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LEPTIN; MALE; MICE; PROSTATIC NEOPLASMS;

EID: 84863435144     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-011-9473-9     Document Type: Article

References (47)

1. Kumar RJ, Barqawi AB, Craw ED (2008) Epidemiology of Prostate Cancer. US Oncology Review 2005
2. Schaid DJ (2004) The complex genetic epidemiology of prostate cancer. Hum Mol Genet 13(1):103-121
3. Mukherjee P, Sotnikov AV, Mangian HJ et al (1999) Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression. J Natl Cancer Inst 91 (6):512-523
4. Bosland MC, Oakley-Girvan I, Whittemore AS (1999) Dietary fat, calories, and prostate cancer risk. J Natl Cancer Inst 91(6):489-491
5. Friedenreich CM, Orenstein MR (2002) Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 132(11 Suppl):3456S-3464S
6. Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579-591
7. Crespo CJ, Smit E, Troiano RP et al (2001) Television watching, energy intake, and obesity in US children: results from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med 155(3):360-365
8. Stubbs CO, Lee AJ (2004) The obesity epidemic: both energy intake and physical activity contribute. Med J Aust 181(9):489-491
9. Mistry T, Digby JE, Desai KM et al (2007) Obesity and prostate cancer: a role for adipokines. Eur Urol 52(1):46-53
10. Garg A (2006) Adipose tissue dysfunction in obesity and lipodystrophy. Clin Cornerstone 8(Suppl 4):S7-S13
11. Trayhurn P, Beattie JH (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 60(3):329-339
12. Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89(6):2548-2556
13. Ronti T, Lupattelli G, Mannarino E (2006) The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf) 64(4):355-365
14. Wajchenberg BL (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21(6):697-738
15. Haque WA, Garg A (2004) Adipocyte biology and adipocytokines. Clin Lab Med 24(1):217-234
16. Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6 (10):772-783
17. Badman MK, Flier JS (2007) The adipocyte as an active participant in energy balance and metabolism. Gastroenterology 132(6):2103-2115
18. Zhang Y, Proenca R, Maffei M et al (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372 (6505):425-432
19. Frederich RC, Hamann A, Anderson S et al (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1(12):1311-1314
20. Boden G, Chen X, Mozzoli M et al (1996) Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 81(9):3419-3423
21. Bjorbaek C, Uotani S, da Silva B et al (1997) Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272(51):32686-32695
22. Tartaglia LA (1997) The leptin receptor. J Biol Chem 272 (10):6093-6096
23. Hoggard N, Hunter L, Duncan JS et al (1997) Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc Natl Acad Sci U S A 94(20):11073-11078
24. Bailleul B, Akerblom I, Strosberg AD (1997) The leptin receptor promoter controls expression of a second distinct protein. Nucleic Acids Res 25(14):2752-2758
25. Somasundar P, Frankenberry KA, Skinner H et al (2004) Prostate cancer cell proliferation is influenced by leptin. J Surg Res 118 (1):71-82
26. Banting FG (1926) An Address on Diabetes and Insulin: Being The Nobel Lecture Delivered at Stockholm on September 15th, 1925. Can Med Assoc J 16(3):221-232
27. Karam JH, Grodsky GM, Forsham PH (1968) Insulin secretion in obesity: pseudodiabetes? Am J Clin Nutr 21(12):1445-1454
28. Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106(4):473-481
29. Cox ME, Gleave ME, Zakikhani M et al (2009) Insulin receptor expression by human prostate cancers. Prostate 69(1):33-40
30. Cullen KJ, Yee D, Sly WS et al (1990) Insulin-like growth factor receptor expression and function in human breast cancer. Cancer Res 50(1):48-53
31. Frasca F, Pandini G, Sciacca L et al (2008) The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem 114(1):23-37
32. Baillargeon J, Rose DP (2006) Obesity, adipokines, and prostate cancer (review). Int J Oncol 28(3):737-745
33. Danforth KN, Rodriguez C, Hayes RB et al (2008) TNF polymorphisms and prostate cancer risk. Prostate 68(4):400-407
34. Ribeiro AM, Andrade S, Pinho F et al (2010) Prostate cancer cell proliferation and angiogenesis in different obese mice models. Int J Exp Pathol 91(4):374-386
35. Baley PA, Yoshida K, Qian W et al (1995) Progression to androgen insensitivity in a novel in vitro mouse model for prostate cancer. J Steroid Biochem Mol Biol 52(5):403-413
36. Freedland SJ, Giovannucci E, Platz EA (2006) Are findings from studies of obesity and prostate cancer really in conflict? Cancer Causes Control 17(1):5-9
37. Giovannucci E, Rimm EB, Liu Y et al (2003) Body mass index and risk of prostate cancer in U.S. health professionals. J Natl Cancer Inst 95(16):1240-1244
38. Malendowicz W, Rucinski M, Macchi C et al (2006) Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat. Int J Mol Med 18(4):615-618
39. Hoda MR, Popken G (2008) Mitogenic and anti-apoptotic actions of adipocyte-derived hormone leptin in prostate cancer cells. BJU Int 102(3):383-388
40. Deo DD, Rao AP, Bose SS et al (2008) Differential effects of leptin on the invasive potential of androgen-dependent and - independent prostate carcinoma cells. J Biomed Biotechnol 2008:163902
41. Hsing AW, Chua S Jr, Gao YT et al (2001) Prostate cancer risk and serum levels of insulin and leptin: a population-based study. J Natl Cancer Inst 93(10):783-789
42. Kelly T, Yang W, Chen CS et al (2008) Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 32(9):1431-1437
43. Farooqi IS, O'Rahilly S (2009) Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 89(3):980S-984S
44. Belkina AC, Denis GV (2010) Obesity genes and insulin resistance. Curr Opin Endocrinol Diabetes Obes 17(5):472-477
45. Muoio DM, Newgard CB (2008) Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 9 (3):193-205
46. Wotton CJ, Yeates DG, Goldacre MJ (2011) Cancer in patients admitted to hospital with diabetes mellitus aged 30 years and over: record linkage studies. Diabetologia 54(3):527-534
47. Polednak AP, Phillips CE (2010) Obtaining data on comorbid diabetes among patients in a U.S. population-based tumor registry. J Registry Manag 37(2):57-64