Tissue distribution and cancer growth inhibition of magnetic lipoplex-delivered type 1 insulin-like growth factor receptor shRNA in nude mice

Acta Biochimica et Biophysica Sinica

Volumn 44, Issue 7, 2012, Pages 591-596

  Kong, Minjian ^a   Li, Xuebiao ^a   Wang, Chunmao ^a   Ding, Chao ^a   Dong, Aiqiang ^a   Duan, Qunjun ^a   Shen, Zhonghua ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

in vivo; insulin like growth factor 1 receptor; lung cancer; nanoparticle magnetofection; small interference RNA

Indexed keywords

GREEN FLUORESCENT PROTEIN; LIPID; SMALL INTERFERING RNA; SOMATOMEDIN C RECEPTOR;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CHEMISTRY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG SCREENING; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; MAGNETIC FIELD; MALE; METABOLISM; METHODOLOGY; MOUSE; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; TISSUE DISTRIBUTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; LIPIDS; LUNG NEOPLASMS; MAGNETIC FIELDS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, FLUORESCENCE; RECEPTOR, IGF TYPE 1; RNA INTERFERENCE; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS; MUS MUSCULUS;

EID: 84863434600     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gms039     Document Type: Article

References (18)

1. Jemal A, Siegel R, Xu J and Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60: 277-300.
2. Yin M, Guan X, Liao Z and Wei Q. Insulin-like growth factor-1 receptortargeted therapy for non-small cell lung cancer: A mini review. Am J Transl Res 2009, 1: 101-114.
3. Dong A, Kong M, Ma Z, Qian J, Cheng H and Xu X. Knock-down of the insulin-like growth factor 1 receptor enhances the chemosensitivity to cisplatin in human lung adenocarcinoma A549 cells. Acta Biochim Biophys Sin 2008, 40: 497-504.
4. Dong A, Kong M, Ma Z, Qian J and Xu X. Down-regulation of IGF1R using small, interfering, hairpin RNA (shRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice. Cell Biol Int 2007, 31: 500-507.
5. Ma Z, Dong A, Kong M and Qian J. Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells. Cell Mol Biol Lett 2007, 12: 556-572.
6. Qian J, Dong A, Kong M, Ma Z, Fan J and Jiang G. Suppression of IGF1R expression by small interfering RNA inhibits A549 human lung cancer cell in vitro invasion and in xenograft nude mice. Acta Biochim Biophys Sin 2007, 39: 137-147.
7. Uprichard SL. The therapeutic potential of RNA interference. FEBS Lett 2005, 579: 5996-6007.
8. Ramesh R, Saeki T, Templeton NS, Ji L, Stephens LC, Ito I and Wilson DR, et al. Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 2001, 3: 337-350.
9. Mykhaylyk YS, Antequera D, Vlaskou D and Plank C. Generation of magnetic nonviral gene transfer agents and magnetofection in vitro. Nat Protoc 2007, 2: 2391-2411.
10. McBain SC, Yiu HH and Dobson J. Magnetic nanoparticles for gene and drug delivery. Int J Nanomed 2008, 3: 169-180.
11. Dobson J. Gene therapy progress and prospects: Magnetic nanoparticlebased gene delivery. Gene Ther 2006, 13: 283-287.
12. Song HP, Yang JY, Lo SL, Wang Y, Fan WM, Tang XS and Xue JM, et al. Gene transfer using self-assembled ternary complexes of cationic magnetic nanoparticles, plasmid DNA and cell-penetrating Tat peptide. Biomaterials 2010, 31: 769-778.
13. Wang C, Ding C, Kong M, Dong A, Qian J, Jiang D and Shen Z. Tumor-targeting magnetic lipoplex delivery of short hairpin RNA suppresses IGF-1R overexpression of lung adenocarcinoma A549 cells in vitro and in vivo. Biochem Biophys Res Commun 2011, 410: 537-442.
14. Scherer F, Anton M, Schillinger U, Henke J, Bergemann C, Krüger A and Gänsbacher B, et al. Magnetofection: Enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther 2002, 9: 102-109.
15. Xenariou S, Griesenbach U, Ferrari S, Dean P, Scheule RK, Cheng SH and Geddes DM, et al. Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo. Gene Ther 2006, 13: 1545-1552.
16. Plank C, Schillinger U, Scherer F, Bergemann C, Remy JS, Krotz F and Anton M, et al. The magnetofection method: Using magnetic force to enhance gene delivery. Biol Chem 2003, 384: 737-747.
17. Huth S, Lausier J, Gersting SW, Rudolph C, Plank C, Welsch U and Rosenecker J. Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer. J Gene Med 2004, 6: 923-936.
18. Krotz F, De Wit C, Sohn HY, Zahler S, Gloe T, Pohl U and Plank C. Magnetofection-a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo. Mol Ther 2003, 7: 700-710.