Two weeks of buspirone protects against posthypoxic ventilatory pauses in the C57BL/6J mouse strain

Respiratory Physiology and Neurobiology

Volumn 183, Issue 1, 2012, Pages 35-40

  Moore, M W ^b   Chai, S ^a,b   Gillombardo, C B ^a,b   Carlo, A ^a   Donovan, L M ^c   Netzer, N ^b,d   Strohl, K P ^a,b,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

5 Hydroxytryptamine 1A; Mouse model; Periodic breathing; Respiratory control

Indexed keywords

4 IODO N [2 [4 (METHOXYPHENYL) 1 PIPERAZINYL] ETHYL] N 2 PYRIDINYL BENZAMIDE; BUSPIRONE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING; BREATHING DISORDER; CONTROLLED STUDY; DRUG MEGADOSE; HYPOXIA; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PLETHYSMOGRAPHY; POSTHYPOXIC VENTILATORY PAUSE; PRIORITY JOURNAL; TREATMENT DURATION;

ANIMALS; ANOXIA; APNEA; BUSPIRONE; MALE; MICE; MICE, INBRED C57BL; PLETHYSMOGRAPHY; RESPIRATION; SEROTONIN RECEPTOR AGONISTS;

EID: 84863430262     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2012.05.001     Document Type: Article

References (16)

1. Andaku D.K., Mercadante M.T., Schwartzman J.S. Buspirone in Rett syndrome respiratory dysfunction. Brain and Development 2005, 27:437-438.
2. El-Khatib M.F., Kiwan R.A., Jamaleddine G.W. Buspirone treatment for apneustic breathing in brain stem infarct. Respiratory Care 2003, 48:956-958.
3. Golder F.J., Zabka A.G., Bavis R.W., Baker-Herman T., Fuller D.D., Mitchell G.S. Differences in time-dependent hypoxic phrenic responses among inbred rat strains. Journal of Applied Physiology 2005, 98:838-844.
4. Gonsenhauser I., Wilson C.G., Han F., Strohl K.P., Dick T.E. Strain differences in murine ventilatory behavior persist after urethane anesthesia. Journal of Applied Physiology 2004, 97:888-894.
5. Han F., Subramanian S., Dick T.E., Dreshaj I.A., Strohl K.P. Ventilatory behavior after hypoxia in C57BL/6J and A/J mice. Journal of Applied Physiology 2001, 91:1962-1970.
6. Lechin F., van der Dijs B., Jara H., Orozco B., Baez S., Benaim M., Lechin M., Lechin A. Effects of buspirone on plasma neurotransmitters in healthy subjects. Journal of Neural Transmission 1998, 105:561-573.
7. Mortola J.P., Frappell P.B. On the barometric method for measurements of ventilation, and its use in small animals. Canadian Journal of Physiology and Pharmacology 1998, 76:937-944.
8. Nishi K., Kanemaru K., Hasegawa S., Watanabe A., Diksic M. Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochemistry International 2009, 54:205-214.
9. Ohlsen R.I., Pilowsky L.S. The place of partial agonism in psychiatry: recent developments. Journal of Psychopharmacology 2005, 19:408-413.
10. Rapoport D.M., Greenberg H.E., Goldring R.M. Differing effects of the anxiolytic agents buspirone and diazepam on control of breathing. Clinical Pharmacology and Therapeutics 1991, 49:394-401.
11. Sato H., Skelin I., Debonnel G., Diksic M. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain Research Bulletin 2008, 75:545-555.
12. Sato H., Skelin I., Diksic M. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain Research 2010, 1345:28-44.
13. Stettner G.M., Zanella S., Hilaire G., Dutschmann M. 8-OH-DPAT suppresses spontaneous central apneas in the C57BL/6J mouse strain. Respiratory Physiology & Neurobiology 2008, 161:10-15.
14. Stettner G.M., Zanella S., Huppke P., Gartner J., Hilaire G., Dutschmann M. Spontaneous central apneas occur in the C57BL/6J mouse strain. Respiratory Physiology & Neurobiology 2008, 160:21-27.
15. Teng Y.D., Bingaman M., Taveira-DaSilva A.M., Pace P.P., Gillis R.A., Wrathall J.R. Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. Journal of Neuroscience 2003, 23:4182-4189.
16. Yamauchi M., Dostal J., Kimura H., Strohl K.P. Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains. Journal of Applied Physiology 2008, 105:518-526.