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Volumn 5, Issue 1, 2012, Pages 15-22

Clinical use of gadobutrol for contrast-enhanced magnetic resonance imaging of neurological diseases

Author keywords

CE MRI; CNS imaging; Gadolinium; Gadovist; Gd BT DO3A; MRI contrast agent

Indexed keywords

GADOBUTROL; GADOLINIUM; PLACEBO;

EID: 84863426938     PISSN: None     EISSN: 11791586     Source Type: Journal    
DOI: 10.2147/RMI.S20665     Document Type: Review
Times cited : (8)

References (53)
  • 3
    • 77957880675 scopus 로고    scopus 로고
    • High-relaxivity contrast-enhanced magnetic resonance neuroimaging: A review
    • Giesel FL, Mehndiratta A, Essig M. High-relaxivity contrast-enhanced magnetic resonance neuroimaging: a review. Eur Radiol. 2010; 20(10):2461-2474.
    • (2010) Eur Radiol , vol.20 , Issue.10 , pp. 2461-2474
    • Giesel, F.L.1    Mehndiratta, A.2    Essig, M.3
  • 4
    • 0033859829 scopus 로고    scopus 로고
    • Neuroimaging: Do we really need new contrast agents for MRI?
    • Roberts TP, Chuang N, Roberts HC. Neuroimaging: do we really need new contrast agents for MRI? Eur J Radiol. 2000;34(3):166-178.
    • (2000) Eur J Radiol , vol.34 , Issue.3 , pp. 166-178
    • Roberts, T.P.1    Chuang, N.2    Roberts, H.C.3
  • 5
    • 36448968297 scopus 로고    scopus 로고
    • Gadolinium chelates: Clinical applications
    • In: Dawson P, Cosgrove DO, Grainger RG, editors, Oxford, UK: Isis Medical Media Ltd
    • Rinck PA, Myhr G. Gadolinium chelates: clinical applications. In: Dawson P, Cosgrove DO, Grainger RG, editors. Textbook of Contrast Media. Oxford, UK: Isis Medical Media Ltd; 1999:333-353.
    • (1999) Textbook of Contrast Media , pp. 333-353
    • Rinck, P.A.1    Myhr, G.2
  • 6
    • 43049121277 scopus 로고    scopus 로고
    • Extracellular gadolinium-based contrast media: An overview
    • Bellin MF, Van Der Molen AJ. Extracellular gadolinium-based contrast media: an overview. Eur J Radiol. 2008;66(2):160-167.
    • (2008) Eur J Radiol , vol.66 , Issue.2 , pp. 160-167
    • Bellin, M.F.1    van der Molen, A.J.2
  • 7
    • 43049091829 scopus 로고    scopus 로고
    • Extracellular gadolinium contrast agents: Differences in stability
    • Morcos SK. Extracellular gadolinium contrast agents: differences in stability. Eur J Radiol. 2008;66(2):175-179.
    • (2008) Eur J Radiol , vol.66 , Issue.2 , pp. 175-179
    • Morcos, S.K.1
  • 8
    • 34247881894 scopus 로고    scopus 로고
    • MR contrast agents: Physical and pharmacologic basics
    • Lin SP, Brown JJ. MR contrast agents: physical and pharmacologic basics. J Magn Reson Imaging. 2007;25(5):884-899.
    • (2007) J Magn Reson Imaging , vol.25 , Issue.5 , pp. 884-899
    • Lin, S.P.1    Brown, J.J.2
  • 9
    • 37549063971 scopus 로고    scopus 로고
    • Gadolinium-containing MRI contrast agents: Important variations on a theme for NSF
    • Kuo PH. Gadolinium-containing MRI contrast agents: important variations on a theme for NSF. J Am Coll Radiol. 2008;5(1): 29-35.
    • (2008) J Am Coll Radiol , vol.5 , Issue.1 , pp. 29-35
    • Kuo, P.H.1
  • 10
    • 0028221220 scopus 로고
    • Safety review of gadopentetate dimeglumine. Extended clinical experience after more than five million applications
    • Niendorf HP, Alhassan A, Geens VR, Clauss W. Safety review of gadopentetate dimeglumine. Extended clinical experience after more than five million applications. Invest Radiol. 1994;29(Suppl 2): S179-S182.
    • (1994) Invest Radiol , vol.29 , Issue.SUPPL. 2
    • Niendorf, H.P.1    Alhassan, A.2    Geens, V.R.3    Clauss, W.4
  • 11
    • 79960845206 scopus 로고    scopus 로고
    • Novel frontiers in ultra-structural and molecular MRI of the brain
    • Duyn JH, Koretsky AP. Novel frontiers in ultra-structural and molecular MRI of the brain. Curr Opin Neurol. 2011;24(4):386-393.
    • (2011) Curr Opin Neurol , vol.24 , Issue.4 , pp. 386-393
    • Duyn, J.H.1    Koretsky, A.P.2
  • 13
    • 79952173274 scopus 로고    scopus 로고
    • Molecular magnetic resonance contrast agents for the detection of cancer: Past and present
    • Bogdanov A Jr, Mazzanti ML. Molecular magnetic resonance contrast agents for the detection of cancer: past and present. Semin Oncol. 2011;38(1):42-54.
    • (2011) Semin Oncol , vol.38 , Issue.1 , pp. 42-54
    • Bogdanov Jr., A.1    Mazzanti, M.L.2
  • 14
    • 77953467091 scopus 로고    scopus 로고
    • An introduction to functional and molecular imaging with MRI
    • Gallagher FA. An introduction to functional and molecular imaging with MRI. Clin Radiol. 2010;65(7):557-566.
    • (2010) Clin Radiol , vol.65 , Issue.7 , pp. 557-566
    • Gallagher, F.A.1
  • 15
    • 0032605215 scopus 로고    scopus 로고
    • Field strength and dose dependence of contrast enhancement by gadolinium-based MR contrast agents
    • Rinck PA, Muller RN. Field strength and dose dependence of contrast enhancement by gadolinium-based MR contrast agents. Eur Radiol. 1999;9(5):998-1004.
    • (1999) Eur Radiol , vol.9 , Issue.5 , pp. 998-1004
    • Rinck, P.A.1    Muller, R.N.2
  • 17
    • 71249102934 scopus 로고    scopus 로고
    • Contemporary applications and limitations of magnetic resonance imaging contrast materials
    • Natalin RA, Prince MR, Grossman ME, Silvers D, Landman J. Contemporary applications and limitations of magnetic resonance imaging contrast materials. J Urol. 2010;183(1):27-33.
    • (2010) J Urol , vol.183 , Issue.1 , pp. 27-33
    • Natalin, R.A.1    Prince, M.R.2    Grossman, M.E.3    Silvers, D.4    Landman, J.5
  • 18
    • 73649093454 scopus 로고    scopus 로고
    • Role of thermodynamic and kinetic parameters in gadolinium chelate stability
    • Idee JM, Port M, Robic C, Medina C, Sabatou M, Corot C. Role of thermodynamic and kinetic parameters in gadolinium chelate stability. J Magn Reson Imaging. 2009;30(6):1249-1258.
    • (2009) J Magn Reson Imaging , vol.30 , Issue.6 , pp. 1249-1258
    • Idee, J.M.1    Port, M.2    Robic, C.3    Medina, C.4    Sabatou, M.5    Corot, C.6
  • 19
    • 34247590053 scopus 로고    scopus 로고
    • Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents
    • Laurent S, Elst LV, Muller RN. Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents. Contrast Media Mol Imaging. 2006;1(3):128-137.
    • (2006) Contrast Media Mol Imaging , vol.1 , Issue.3 , pp. 128-137
    • Laurent, S.1    Elst, L.V.2    Muller, R.N.3
  • 21
    • 0000685174 scopus 로고    scopus 로고
    • Synthesis and structure of a new macrocyclic polyhydroxylated gadolinium chelate used as a contrast agent for magnetic resonance imaging
    • Platzek J, Blaszkiewicz P, Gries H, et al. Synthesis and structure of a new macrocyclic polyhydroxylated gadolinium chelate used as a contrast agent for magnetic resonance imaging. Inorg Chem. 1997; 36(26):6086-6093.
    • (1997) Inorg Chem , vol.36 , Issue.26 , pp. 6086-6093
    • Platzek, J.1    Blaszkiewicz, P.2    Gries, H.3
  • 22
    • 0035121874 scopus 로고    scopus 로고
    • Stability of MRI paramagnetic contrast media: A proton relaxometric protocol for transmetallation assessment
    • Laurent S, Elst LV, Copoix F, Muller RN. Stability of MRI paramagnetic contrast media: a proton relaxometric protocol for transmetallation assessment. Invest Radiol. 2001;36(2):115-122.
    • (2001) Invest Radiol , vol.36 , Issue.2 , pp. 115-122
    • Laurent, S.1    Elst, L.V.2    Copoix, F.3    Muller, R.N.4
  • 23
    • 45849113240 scopus 로고    scopus 로고
    • Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: A critical review
    • Port M, Idee JM, Medina C, Robic C, Sabatou M, Corot C. Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: a critical review. Biometals. 2008;21(4):469-490.
    • (2008) Biometals , vol.21 , Issue.4 , pp. 469-490
    • Port, M.1    Idee, J.M.2    Medina, C.3    Robic, C.4    Sabatou, M.5    Corot, C.6
  • 24
    • 34250025385 scopus 로고    scopus 로고
    • Gadolinium use in patients with kidney disease: A cause for concern
    • Perazella MA, Rodby RA. Gadolinium use in patients with kidney disease: a cause for concern. Semin Dial. 2007;20(3):179-185.
    • (2007) Semin Dial , vol.20 , Issue.3 , pp. 179-185
    • Perazella, M.A.1    Rodby, R.A.2
  • 25
    • 34547477080 scopus 로고    scopus 로고
    • Gadolinium and nephrogenic systemic fibrosis
    • Grobner T, Prischl FC. Gadolinium and nephrogenic systemic fibrosis. Kidney Int. 2007;72(3):260-264.
    • (2007) Kidney Int , vol.72 , Issue.3 , pp. 260-264
    • Grobner, T.1    Prischl, F.C.2
  • 26
    • 34247889994 scopus 로고    scopus 로고
    • Safety update on the possible causal relationship between gadolinium-containing MRI agents and nephrogenic systemic fibrosis
    • Pedersen M. Safety update on the possible causal relationship between gadolinium-containing MRI agents and nephrogenic systemic fibrosis. J Magn Reson Imaging. 2007;25(5):881-883.
    • (2007) J Magn Reson Imaging , vol.25 , Issue.5 , pp. 881-883
    • Pedersen, M.1
  • 27
    • 84863448842 scopus 로고    scopus 로고
    • Gadobutrol. Gd-DO3A-butrol
    • Bethesda (MD): National Library of Medicine (US), NCBI; 2004-2012. Available from, Accessed February 9, 2012
    • Cheng KT. Gadobutrol. Gd-DO3A-butrol. In: Molecular Imaging and Contrast Agent Database (MICAD) [database on the Internet]. Bethesda (MD): National Library of Medicine (US), NCBI; 2004-2012. Available from: http://www.ncbi.nlm.nih.gov/books/NBK23589/. Accessed February 9, 2012.
    • Molecular Imaging and Contrast Agent Database (MICAD) [database On the Internet]
    • Cheng, K.T.1
  • 28
    • 84863453950 scopus 로고    scopus 로고
    • Available from, Accessed February 9, 2012
    • Gadovist® [product information]. 2010. Available from: http:// www.medsafe.govt.nz/profs/datasheet/g/Gadovistinj.pdf. Accessed February 9, 2012.
    • (2010) Gadovist® [product information]
  • 29
    • 0028892584 scopus 로고
    • Pre-clinical evaluation of gadobutrol: A new, neutral, extracellular contrast agent for magnetic resonance imaging
    • Vogler H, Platzek J, Schuhmann-Giampieri G, et al. Pre-clinical evaluation of gadobutrol: a new, neutral, extracellular contrast agent for magnetic resonance imaging. Eur J Radiol. 1995;21(1):1-10.
    • (1995) Eur J Radiol , vol.21 , Issue.1 , pp. 1-10
    • Vogler, H.1    Platzek, J.2    Schuhmann-Giampieri, G.3
  • 30
    • 33646198875 scopus 로고    scopus 로고
    • Relaxivity of gadopentetate dimeglumine (magnevist), gadobutrol (gadovist), and gadobenate dimeglumine (multihance) in human blood plasma at 0.2, 1.5, and 3 Tesla
    • Pintaske J, Martirosian P, Graf H, et al. Relaxivity of gadopentetate dimeglumine (magnevist), gadobutrol (gadovist), and gadobenate dimeglumine (multihance) in human blood plasma at 0.2, 1.5, and 3 Tesla. Invest Radiol. 2006;41(3):213-221.
    • (2006) Invest Radiol , vol.41 , Issue.3 , pp. 213-221
    • Pintaske, J.1    Martirosian, P.2    Graf, H.3
  • 31
    • 0036895866 scopus 로고    scopus 로고
    • Interstitial magnetic resonance lymphography with gadobutrol in rats: Evaluation of contrast kinetics
    • Fink C, Bock M, Kiessling F, Delorme S. Interstitial magnetic resonance lymphography with gadobutrol in rats: evaluation of contrast kinetics. Invest Radiol. 2002;37(12):655-662.
    • (2002) Invest Radiol , vol.37 , Issue.12 , pp. 655-662
    • Fink, C.1    Bock, M.2    Kiessling, F.3    Delorme, S.4
  • 32
    • 0034798727 scopus 로고    scopus 로고
    • Comparative study between gadobenate dimeglumine and gadobutrol in rats with brain ischemia: Evaluation of somatosensory evoked potentials
    • Frigeni V, Miragoli L, Grotti And A, Lorusso V. Comparative study between gadobenate dimeglumine and gadobutrol in rats with brain ischemia: evaluation of somatosensory evoked potentials. Invest Radiol. 2001;36(10):561-572.
    • (2001) Invest Radiol , vol.36 , Issue.10 , pp. 561-572
    • Frigeni, V.1    Miragoli, L.2    Grotti And, A.3    Lorusso, V.4
  • 33
    • 0032928056 scopus 로고    scopus 로고
    • Comparison of a 1.0 molar and a 0.5 molar formulation of gadobutrol in dynamic MR imaging of the liver in rats with hepatocellular carcinoma
    • Kawai J, Takahashi M, Kato N, Takashima K, Miyazawa T. Comparison of a 1.0 molar and a 0.5 molar formulation of gadobutrol in dynamic MR imaging of the liver in rats with hepatocellular carcinoma. Magn Reson Imaging. 1999;17(1):91-97.
    • (1999) Magn Reson Imaging , vol.17 , Issue.1 , pp. 91-97
    • Kawai, J.1    Takahashi, M.2    Kato, N.3    Takashima, K.4    Miyazawa, T.5
  • 34
    • 3042660192 scopus 로고    scopus 로고
    • In vivo measurement of gadolinium concentration in a rat glioma model by monochromatic quantitative computed tomography: Comparison between gadopentetate dimeglumine and gadobutrol
    • Le Duc G, Corde S, Charvet A, et al. In vivo measurement of gadolinium concentration in a rat glioma model by monochromatic quantitative computed tomography: comparison between gadopentetate dimeglumine and gadobutrol. Invest Radiol. 2004;39(7):385-393.
    • (2004) Invest Radiol , vol.39 , Issue.7 , pp. 385-393
    • le Duc, G.1    Corde, S.2    Charvet, A.3
  • 35
    • 0031397814 scopus 로고    scopus 로고
    • Assessment of reperfusion injury by means of MR contrast agents in rat liver
    • Reimer P, Allkemper T, Bremer C, et al. Assessment of reperfusion injury by means of MR contrast agents in rat liver. J Magn Reson Imaging. 1997;7(3):490-494.
    • (1997) J Magn Reson Imaging , vol.7 , Issue.3 , pp. 490-494
    • Reimer, P.1    Allkemper, T.2    Bremer, C.3
  • 36
    • 67651047054 scopus 로고    scopus 로고
    • Comparative evaluation of lesion enhancement using 1 M gadobutrol vs 2 conventional gadolinium chelates, all at a dose of 0.1 mmol/kg, in a rat brain tumor model at 3 T
    • Attenberger UI, Runge VM, Jackson CB, et al. Comparative evaluation of lesion enhancement using 1 M gadobutrol vs 2 conventional gadolinium chelates, all at a dose of 0.1 mmol/kg, in a rat brain tumor model at 3 T. Invest Radiol. 2009;44(5):251-256.
    • (2009) Invest Radiol , vol.44 , Issue.5 , pp. 251-256
    • Attenberger, U.I.1    Runge, V.M.2    Jackson, C.B.3
  • 37
    • 77649206972 scopus 로고    scopus 로고
    • Evaluation of gadobutrol, a macrocyclic, nonionic gadolinium chelate in a brain glioma model: Comparison with gadoterate meglumine and gadopentetate dimeglumine at 1.5 T, combined with an assessment of field strength dependence, specifically 1.5 versus 3 T
    • Attenberger UI, Runge VM, Morelli JN, Williams J, Jackson CB, Michaely HJ. Evaluation of gadobutrol, a macrocyclic, nonionic gadolinium chelate in a brain glioma model: comparison with gadoterate meglumine and gadopentetate dimeglumine at 1.5 T, combined with an assessment of field strength dependence, specifically 1.5 versus 3 T. J Magn Reson Imaging. 2010;31(3):549-555.
    • (2010) J Magn Reson Imaging , vol.31 , Issue.3 , pp. 549-555
    • Attenberger, U.I.1    Runge, V.M.2    Morelli, J.N.3    Williams, J.4    Jackson, C.B.5    Michaely, H.J.6
  • 38
    • 77951954877 scopus 로고    scopus 로고
    • Brain MRI with single-dose (0.1 mmol/kg) Gadobutrol at 1.5 T and 3 T: Comparison with 0.15 mmol/kg Gadoterate meglumine
    • Kramer H, Runge VM, Naul LG, Loynachan AT, Reiser MF, Wintersperger BJ. Brain MRI with single-dose (0.1 mmol/kg) Gadobutrol at 1.5 T and 3 T: comparison with 0.15 mmol/kg Gadoterate meglumine. AJR Am J Roentgenol. 2010;194(5):1337-1342.
    • (2010) AJR Am J Roentgenol , vol.194 , Issue.5 , pp. 1337-1342
    • Kramer, H.1    Runge, V.M.2    Naul, L.G.3    Loynachan, A.T.4    Reiser, M.F.5    Wintersperger, B.J.6
  • 39
    • 0028102034 scopus 로고
    • Pharmacokinetics, dose proportionality, and tolerability of gadobutrol after single intravenous injection in healthy volunteers
    • Staks T, Schuhmann-Giampieri G, Frenzel T, Weinmann H, Lange L, Platzek J. Pharmacokinetics, dose proportionality, and tolerability of gadobutrol after single intravenous injection in healthy volunteers. Invest Radiol. 1994;29(7):709-715.
    • (1994) Invest Radiol , vol.29 , Issue.7 , pp. 709-715
    • Staks, T.1    Schuhmann-Giampieri, G.2    Frenzel, T.3    Weinmann, H.4    Lange, L.5    Platzek, J.6
  • 40
    • 33646551152 scopus 로고    scopus 로고
    • Intraindividual comparison of gadobenate dimeglumine and gadobutrol for cerebral magnetic resonance perfusion imaging at 1.5 T
    • Essig M, Lodemann KP, Le-Huu M, Bruning R, Kirchin M, Reith W. Intraindividual comparison of gadobenate dimeglumine and gadobutrol for cerebral magnetic resonance perfusion imaging at 1.5 T. Invest Radiol. 2006;41(3):256-263.
    • (2006) Invest Radiol , vol.41 , Issue.3 , pp. 256-263
    • Essig, M.1    Lodemann, K.P.2    Le-Huu, M.3    Bruning, R.4    Kirchin, M.5    Reith, W.6
  • 41
    • 0036594278 scopus 로고    scopus 로고
    • Value of 1.0-M gadolinium chelates: Review of preclinical and clinical data on gadobutrol
    • Tombach B, Heindel W. Value of 1.0-M gadolinium chelates: review of preclinical and clinical data on gadobutrol. Eur Radiol. 2002; 12(6):1550-1556.
    • (2002) Eur Radiol , vol.12 , Issue.6 , pp. 1550-1556
    • Tombach, B.1    Heindel, W.2
  • 42
    • 18044393273 scopus 로고    scopus 로고
    • Gadobutrol, a highly concentrated MR-imaging contrast agent: Its physicochemical characteristics and the basis for its use in contrast-enhanced MR angiography and perfusion imaging
    • Huppertz A, Rohrer M. Gadobutrol, a highly concentrated MR-imaging contrast agent: its physicochemical characteristics and the basis for its use in contrast-enhanced MR angiography and perfusion imaging. Eur Radiol. 2004;14(Suppl 5):M12-M18.
    • (2004) Eur Radiol , vol.14 , Issue.SUPPL. 5
    • Huppertz, A.1    Rohrer, M.2
  • 43
    • 0033982129 scopus 로고    scopus 로고
    • Pharmacokinetics of 1Mgadobutrol in patients with chronic renal failure
    • Tombach B, Bremer C, Reimer P, et al. Pharmacokinetics of 1Mgadobutrol in patients with chronic renal failure. Invest Radiol. 2000;35(1):35-40.
    • (2000) Invest Radiol , vol.35 , Issue.1 , pp. 35-40
    • Tombach, B.1    Bremer, C.2    Reimer, P.3
  • 44
    • 73349084644 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of gadobutrol-enhanced magnetic resonance imaging in pediatric patients
    • Hahn G, Sorge I, Gruhn B, et al. Pharmacokinetics and safety of gadobutrol-enhanced magnetic resonance imaging in pediatric patients. Invest Radiol. 2009;44(12):776-783.
    • (2009) Invest Radiol , vol.44 , Issue.12 , pp. 776-783
    • Hahn, G.1    Sorge, I.2    Gruhn, B.3
  • 45
    • 70350020616 scopus 로고    scopus 로고
    • Detection of cerebral metastases on magnetic resonance imaging: Intraindividual comparison of gadobutrol with gadopentetate dimeglumine
    • Anzalone N, Gerevini S, Scotti R, Vezzulli P, Picozzi P. Detection of cerebral metastases on magnetic resonance imaging: intraindividual comparison of gadobutrol with gadopentetate dimeglumine. Acta Radiol. 2009;50(8):933-940.
    • (2009) Acta Radiol , vol.50 , Issue.8 , pp. 933-940
    • Anzalone, N.1    Gerevini, S.2    Scotti, R.3    Vezzulli, P.4    Picozzi, P.5
  • 46
    • 77953509943 scopus 로고    scopus 로고
    • Diagnostic yield of double-dose gadobutrol in the detection of brain metastasis: Intraindividual comparison with double-dose gadopentetate dimeglumine
    • Kim ES, Chang JH, Choi HS, Kim J, Lee SK. Diagnostic yield of double-dose gadobutrol in the detection of brain metastasis: intraindividual comparison with double-dose gadopentetate dimeglumine. AJNR Am J Neuroradiol. 2010;31(6):1055-1058.
    • (2010) AJNR Am J Neuroradiol , vol.31 , Issue.6 , pp. 1055-1058
    • Kim, E.S.1    Chang, J.H.2    Choi, H.S.3    Kim, J.4    Lee, S.K.5
  • 47
    • 79959975632 scopus 로고    scopus 로고
    • Magnetic resonance evaluation of brain metastases from systemic malignances with two doses of gadobutrol 1.0 m compared with gadoteridol: A multicenter, phase ii/iii study in patients with known or suspected brain metastases
    • Katakami N, Inaba Y, Sugata S, et al. Magnetic resonance evaluation of brain metastases from systemic malignances with two doses of gadobutrol 1.0 m compared with gadoteridol: a multicenter, phase ii/iii study in patients with known or suspected brain metastases. Invest Radiol. 2011;46(7):411-418.
    • (2011) Invest Radiol , vol.46 , Issue.7 , pp. 411-418
    • Katakami, N.1    Inaba, Y.2    Sugata, S.3
  • 48
    • 82955162355 scopus 로고    scopus 로고
    • Cerebral neoplastic enhancing lesions: Multicenter, randomized, crossover intraindividual comparison between gadobutrol (1.0M) and gadoterate meglumine (0.5M) at 0.1 mmolGd/kg body weight in a clinical setting
    • Epub Sep 2
    • Anzalone N, Scarabino T, Venturi C, et al. Cerebral neoplastic enhancing lesions: Multicenter, randomized, crossover intraindividual comparison between gadobutrol (1.0M) and gadoterate meglumine (0.5M) at 0.1 mmolGd/kg body weight in a clinical setting. Eur J Radiol. 2011. Epub Sep 2.
    • (2011) Eur J Radiol
    • Anzalone, N.1    Scarabino, T.2    Venturi, C.3
  • 49
    • 0037626029 scopus 로고    scopus 로고
    • Using a 1 M Gd-chelate (gadobutrol) for total-body three-dimensional MR angiography: Preliminary experience
    • Goyen M, Herborn CU, Vogt FM, et al. Using a 1 M Gd-chelate (gadobutrol) for total-body three-dimensional MR angiography: preliminary experience. J Magn Reson Imaging. 2003;17(5):565-571.
    • (2003) J Magn Reson Imaging , vol.17 , Issue.5 , pp. 565-571
    • Goyen, M.1    Herborn, C.U.2    Vogt, F.M.3
  • 50
    • 0036135655 scopus 로고    scopus 로고
    • Using highly concentrated gadobutrol as an MR contrast agent in patients also requiring hemodialysis: Safety and dialysability
    • Tombach B, Bremer C, Reimer P, et al. Using highly concentrated gadobutrol as an MR contrast agent in patients also requiring hemodialysis: safety and dialysability. AJR Am J Roentgenol. 2002; 178(1):105-109.
    • (2002) AJR Am J Roentgenol , vol.178 , Issue.1 , pp. 105-109
    • Tombach, B.1    Bremer, C.2    Reimer, P.3
  • 51
    • 35848968245 scopus 로고    scopus 로고
    • Biochemical safety profiles of gadolinium-based extracellular contrast agents and nephrogenic systemic fibrosis
    • Ersoy H, Rybicki FJ. Biochemical safety profiles of gadolinium-based extracellular contrast agents and nephrogenic systemic fibrosis. J Magn Reson Imaging. 2007;26(5):1190-1197.
    • (2007) J Magn Reson Imaging , vol.26 , Issue.5 , pp. 1190-1197
    • Ersoy, H.1    Rybicki, F.J.2
  • 52
    • 80053605686 scopus 로고    scopus 로고
    • Safety of gadobutrol, a new generation of contrast agents: Experience from clinical trials and postmarketing surveillance
    • Voth M, Rosenberg M, Breuer J. Safety of gadobutrol, a new generation of contrast agents: experience from clinical trials and postmarketing surveillance. Invest Radiol. 2011;46(11):663-671.
    • (2011) Invest Radiol , vol.46 , Issue.11 , pp. 663-671
    • Voth, M.1    Rosenberg, M.2    Breuer, J.3
  • 53
    • 84863433895 scopus 로고    scopus 로고
    • January 21, Available from, Accessed February 28, 2012
    • Briefing document for gadobutrol injection NDA 201,277, Bayer Health-Care Pharmaceuticals. January 21, 2011. Available from: http://www.fda. gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/ Drugs/PeripheralandCentralNervousSystemDrugsAdvisoryCommittee/ UCM240357.pdf. Accessed February 28, 2012.
    • (2011) Briefing Document For Gadobutrol Injection NDA 201,277, Bayer Health-Care Pharmaceuticals


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.