Lentivirally overexpressed T-bet regulates T-helper cell lineage commitment in chronic hepatitis B patients

Molecular Medicine Reports

Volumn 6, Issue 2, 2012, Pages 361-366

  Liu, Xueni ^a   Tang, Zhenghao ^a   Zhang, Y I ^a   Hu, Jianjun ^a   Li, Dan ^a   Zang, Guoqing ^a   Yu, Yongsheng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Chronic hepatitis b; GATA 3; H2.0 like homeobox; STAT 6; T helper cells; T bet

Indexed keywords

DNA FRAGMENT; GREEN FLUORESCENT PROTEIN; HEPATITIS B(E) ANTIGEN; LENTIVIRUS VECTOR; MESSENGER RNA; PLASMID VECTOR; STAT6 PROTEIN; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL LINEAGE; CELL POLARITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE OVEREXPRESSION; HUMAN; MALE; MOLECULAR CLONING; REAL TIME POLYMERASE CHAIN REACTION; TH1 CELL; TH2 CELL;

ADULT; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELL LINEAGE; CLONING, MOLECULAR; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HOMEODOMAIN PROTEINS; HUMANS; LENTIVIRUS; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAT6 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

HEPATITIS B VIRUS;

EID: 84863423051     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.905     Document Type: Article

References (29)

1. Guidotti LG and Chisari FV: Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 1: 23-61, 2006.
2. Asabe S, Wieland SF, Chattopadhyay PK, et al: The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol 83: 9652-9662, 2009.
3. Lewis MD, Miller SA, Miazgowicz MM, Beima KM and Weinmann AS: T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain. Mol Cell Biol 27: 8510-8521, 2007.
4. Beima KM, Miazgowicz MM, Lewis MD, Yan PS, Huang TH and Weinmann AS: T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem 281: 11992-12000, 2006. (Pubitemid 43855463)
5. Pai SY, Truitt ML and Ho IC: GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci USA 101: 1993-1998, 2004. (Pubitemid 38229003)
6. Ansel KM, Djuretic I, Tanasa B and Rao A: Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol 24: 607-656, 2006.
7. Gutiérrez-García ML, Fernandez-Rodriguez CM, Lledo-Navarro JL and Buhigas-Garcia I: Prevalence of occult hepatitis B virus infection. World J Gastroenterol 17: 1538-1542, 2011.
8. Raimondo G, Pollicino T, Cacciola I and Squadrito G: Occult hepatitis B virus infection. J Hepatol 46: 160-170, 2007. (Pubitemid 44827430)
9. Mizukoshi E, Sidney J, Livingston B, et al: Cellular immune responses to the hepatitis B virus polymerase. J Immunol 173: 5863-5871, 2004. (Pubitemid 39392177)
10. Brooks DG, Teyton L, Oldstone MB and McGavern DB: Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. J Virol 79: 10514-10527, 2005. (Pubitemid 41098591)
11. Jiang R, Feng X, Guo Y, et al: T helper cells in patients with chronic hepatitis B virus infection. Chin Med J (Engl) 115: 422-424, 2002.
12. Akpolat N, Yahsi S, Godekmerdan A, Demirbag K and Yalniz M: Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B. World J Gastroenterol 11: 3260-3263, 2005. (Pubitemid 40973896)
13. + T cell responses during chronic infection. Nat Immunol 12: 663-671, 2011.
14. Kootstra NA and Verma IM: Gene therapy with viral vectors. World J Gastroenterol 43: 413-439, 2003. (Pubitemid 37372648)
15. Montini E, Cesana D, Schmidt M, et al: The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. Clin Invest 119: 964-975, 2009.
16. Abordo-Adesida E, Follenzi A, Barcia C, et al: Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses. Hum Gene Ther 16: 741-751, 2005. (Pubitemid 40864274)
17. Mátrai J, Chuah MK and VandenDriessche T: Recent advances in lentiviral vector development and applications. Mol Ther 18: 477-490, 2010.
18. Meuer SC, Hussey RE, Cantrell DA, et al: Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci USA 81: 1509-1513, 1984. (Pubitemid 14174532)
19. Liao W, Lin JX, Wang L, Li P and Leonard WJ: Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol 12: 551-559, 2011.
20. Zheng WP, Zhao Q, Zhao X, et al: Up-regulation of Hlx in immature Th cells induces IFN-gamma expression. J Immunol 172: 114-122, 2004. (Pubitemid 38020462)
21. Mullen AC, Hutchins AS, High FA, et al: Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol 3: 652-658, 2002. (Pubitemid 34752474)
22. Hamalainen-Laanaya HK, Kobie JJ, Chang C and Zeng WP: Temporal and spatial changes of histone 3 K4 dimethylation at the IFN-gamma gene during Th1 and Th2 cell differentiation. J Immunol 179: 6410-6415, 2007.
23. Farrar JD, Ouyang W, Löhning M, et al: An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3. J Exp Med 193: 643-650, 2001.
24. Nawijn MC, Dingjan GM, Ferreira R, et al: Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo. J Immunol 167: 724-732, 2001. (Pubitemid 32660825)
25. Skapenko A, Leipe J, Niesner U, et al: GATA-3 in human T cell helper type 2 development. J Exp Med 199: 423-428, 2004. (Pubitemid 38252054)
26. Zhu J, Min B, Hu-Li J, et al: Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol 5: 1157-1165, 2004. (Pubitemid 39549630)
27. Hwang ES, Hong JH and Glimcher LH: IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med 202: 1289-1300, 2005.
28. Zhu J, Guo L, Watson CJ, Hu-Li J and Paul WE: Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion. J Immunol 166: 7276-7281, 2001. (Pubitemid 32525602)
29. Goenka S and Kaplan MH: Transcriptional regulation by STAT6. Immunol Res 50: 87-96, 2011.